- Disowned Adaptation: The author, Susanna Kaysen, was among the detractors of the film, accusing James Mangold of adding "melodramatic drivel" to the story by inventing plot points that were not in the book (such as Lisa and Susanna running away together).
- Method Acting: Angelina Jolie avoided any communication with Winona Ryder when making the movie, claiming that if she saw anything human about Winona Ryder, she would not have been able to act out the sociopath character Lisa Rowe as effectively.
- What Could Have Been: Claire Danes, Katie Holmes, Kate Hudson, Rose McGowan, Gretchen Mol, Sarah Polley, Christina Ricci, Reese Witherspoon and Alicia Witt all auditioned for unspecified roles. James Mangold also met with Courtney Love to discuss the role of Lisa as well as Alanis Morissette for a role. Parker Posey turned down a role, while Leelee Sobieski signed on to play Daisy but dropped out weeks before filming began after receiving an offer to star in Joan of Arc.
Trivia / Girl, Interrupted