Peter's wish to go out and live like a single guy again (thanks to Death) leads to an alternate reality where Lois is married to Quagmire and Peter is the husband of former Brat Pack star, Molly Ringwald.
- Actor Allusion: The joke about Osama bin Laden being on Mad TV which is why no one can find him also references a little-known role Alex Borstein (the voice of Lois) had before Family Guy — a cast member on MADtv.
- Art Shift: The cutaway gag about The Jetsons is done in the show's original style.
- Bad Future: Ultimately subverted—while the changes in Peter (and Brian's) new life are certainly very extremenote , the good things ultimately outweigh the bad things. Brian even admits to Peter, "As much I hate say to it, you not marrying Lois was the best that ever could've happened to the world." To name some of the good things in the new timeline:
- Al Gore became President in 2000, and he killed Osama Bin Laden with his bare hands.
- There are flying cars that run on vegetable oil.
- With people being much more health-conscious and President Gore having implemented Universal Healthcare, Americans are living much longer.
- The United States also now has Zero Tolerance Gun Control and a much stronger/more well-funded educational system, which are at least two of the factors to the country now having hardly any street crime.
- Dick Cheney (who obviously did not become Vice President in this timeline) simultaneously killed Justice Antonin Scalia, Karl Rove, and Tucker Carlson in a hunting accident.
- Bowdlerization: The following scenes were cut/edited when aired on FOX compared to the DVD and [adult swim] version:
- Brian's line to young Lois on FOX was "Can I WHAM! my Oingo Boingo into your Velvet Underground?"; on DVD and Adult Swim, it was "I would eat your poo"note
- The scene of the 1980s collar guy challenging Brian to a fight cuts off before Brian can say anything in the FOX version; on DVD and Adult Swim, the 1980s collar guy says, "I'll fight you anytime, anywhere." Brian suggests that the two fight on September 11th 2001, at 8:00 am on top of the World Trade Center.
- Quagmire's roleplaying game he plays with Lois on FOX is "Schoolgirl and Guy Who Has Sex with the Schoolgirl"; on DVD and Adult Swim, it's "Hide and Go Anal."
- The parody of The Jetsons opening on the TV version (both FOX and [adult swim]) has George say, "Bull...crap" after Jane tries to explain that she's not going to take his wallet this time. On DVD, the line is "Bull...shit."
- During the dance on the FOX version, Lois asks what's poking her and Quagmire says, "It's just my wang." On [adult swim] and the DVD, he uses the more upfront word, "penis."
- Brick Joke: The Jetsons cutaway ends with George sending Jane falling a long distance from the hovercar. Later, she lands next to Peter and Brian.
- Call-Forward: At the prom, Peter accidentally bumps into his enemy, Ernie the Giant Chicken. His friend next to him tells him to let it go and that he'll probably never see Peter again.
- The Cameo: In the final gag of the episode, Lois says she's thankful that everything is now back to normal... only for Roger from American Dad! to enter the living room asking who ate all the pecan sandies.
- I Was Quite a Looker: Molly Ringwald becomes this in the universe where she married Peter, looking about a decade older than her real age (39 in 2007). Judd Nelson also comes by and looks very decrepit.
- Take That!
Quagmire: Wow, the perfect hiding spot. The one place no one would look.
- It is mentioned that Osama bin Laden was hiding within the cast of Mad TV, a jab at the show not being as prominent or popular as Saturday Night Live. The joke is made funnier for two reasons: 1) MADtv got canceled in 2009 due to low ratings and FOX cutting the budget on late-night TV shows (at least until they brought in Animation Domination High Defnote ) and 2) Osama bin Laden was found and killed two years after MADtv ended.