In this Bizarro Episode, the Griffins are survivors of the apocalypse caused by the Y2K computer virus and head off to Natuck to rebuild society near a Twinkie factory.
- After the End: The Setting.
- All Just a Dream: The whole episode is revealed to be a dream of Pamela Ewing's, parodying Dallas.
Pamela Ewing: Oh, Bobby, I just had the weirdest dream. I dreamt I saw the strangest episode of Family Guy, and there was a giant chicken and Stewie was an octopus.
Bobby Ewing: Hey, hey, hey. Come on, now. It's all right. Everything's going to be OK. ...What's Family Guy?
- Bait-and-Switch: Twice. After being told all about Y2K, Peter asks the man dressed as a giant chicken if he's selling chicken or sex jelly (K-Y). After the man corrects him again about the upcoming dangers of Y2K, Peter lets out a Big "NO!"... because he saw the Trix Rabbit got a box of the cereal and chastises the rabbit before asking the chicken man again what was he was explaining to him about Y2K.
- Big Eater: Even after the Y2K apocalypse happens, Peter manages to eat an entire year's worth of food.
- Body Horror: After accidentally falling into a vat of nuclear waste, Stewie's morph into octopus tentacles and continue until his whole lower-half of his body has morphed into that of an octopus.
- After Y2K happens, Cleveland and Quagmire ended up with both their bodies fused together.
- Joe wheelchair melted into the ground with his lower half stuck inside the gravel.
- Bring It: After the family leaves for Natuck, Joe (fused to his driveway) is approached by a giant rat. His response? "BRING IT ON!"
- Black Comedy Cannibalism: After the end of the world has happened and Quahog is in ruins, Tom Tucker and Diane Simmons have decided to cannibalize their Asian co-worker Trisha Takanawa.
Tom Tucker: So what do think, Diane? Can I cook or what?
Diane Simmons: Mmm, delicious, Tom! I guess we should be eating her with chopsticks. (both end up laughing)
- Dramatic Irony: After being kicked out of New Quahog, Peter apologizes, saying that people apparently didn't need guns, all of them unaware of what's transpiring in the gun-less town behind them.
- Hazmat Suit: Peter has the family wear ones while hiding in the basement.
- Indestructible Edible: Why the family seeks out the Twinkie factory, Peter claiming that they, along with cockroaches, are guaranteed to survive a nuclear holocaust.
- I'm a Humanitarian: While savaging for food at the abandoned Local Stop-And-Shop, Peter and Brian are drawn to the mysterious smell of barbecue and are shocked to discover the source of the smell: Tom Tucker and Diane Simmons have cannibalized Asian reporter Trisa Takanawa.
Brian: (horrified) My God! They're eating Asian reporter Trisha Takanawa!
- Irony: Lampshaded and discussed by two random guys when Octo-Stewies overrun the town after they get rid of the guns.
Random guy: Hey Bob, you remember the other day you were asking me what the definition of irony was and I said-
Octo-Stewie latches onto his face
Random guy: AHHHH!
- Mr Sea Horse: Stewie, after morphing into an octopus hybrid, lays an egg and then lays a huge pile of more eggs.
- Noodle Incident: After being thrown out of New Quahog, Peter admits he hasn't been thrown out of any place since that time he worked at a bulimia clinic.
Peter: (to a group of bulimics) Man! Did anyone else throw up after eating that fish last night?
- Off Screen Death: Meg's date Kevin Swanson got vaporized by the nuclear blast of the Y2K apocalypse.
- Properly Paranoid: After hearing about the Y2K rumor, Peter immediately builds a fallout shelter in the basement and forcibly barricades the family in it. Despite Lois's disbelief, The End of the World as We Know It does happen. Following that, Peter leads the family to Natuck where he believes that a Twinkie factory survived the apocalypse, and turned out to be right again. These instances lead Peter to believe that New Quahog needs guns and so cannibalizes the town's plumbing to fashion them, which unfortunately gets him and the others thrown out of the town. Despite the town's disbelief however, it turns out they do need the guns when Stewie's Weaponized Offspring go on a rampage. Ironically, however, the Griffins are unaware of this and Peter says that he's not always right.
- When the family first sees Peter in a hazmat suit, Chris screams that the government is here and tells E.T. to run. We then see him do just that.
- "Game over, man. Game over!"
- Tempting Fate: After throwing the last of the guns into a huge fire, the townspeople of New Quahog ask what would they ever need guns for? Cue the army of evil Stewie-hybrid offspring coming right at them.
- Weaponized Offspring: The nuclear holocaust mutates Stewie into a half-human-half-octopus creature, who then lays a huge pile of eggs. Next scene, an army of human-octopi march through the town chanting "victory is ours", and attack the people by jumping at them and grabbing their faces with their tentacles.