Tear Jerker: Any episode about Nobita's grandma.
- And the episode where Shizuka adopts a doll and asks Doraemon to make her a sentient one so they can find its owner...
- The episode where Nobita accidentally called a Snow Spirit. They started as a friend until the spirit became a Clingy Jealous Girl towards Nobita and forced him to play hours in a snow storm. Nobita caught a very bad fever as the result. Knowing she really liked Nobita and felt bad that Nobita got sick because of her, she sacrificed herself to heal Nobita's fever and in exchange she had to vanished with the winter and spring came early instead.
- The movie where a portal to another dimension forms under a floor tile in Nobita's room (the original Nobita and the Steel Troops?). Doraemon finds a love interest there, and said portal gets destroyed at the end of the movie, severing Doraemon from ever being able to visit his love interest ever again. The movie's Award Bait tear jerker of a theme song (played as the portal vanishes) brings on the full effect.
- And of course, the final chapter of Volume 6 of the manga, as well as the first chapter of Volume 7. Which was adapted into a half-hour long TV special in two parts.
- Some of the fan-written endings mentioned above as well. Especially the infamous "happy ending", when the repaired Doraemon wakes up for the first time in 35 years, and Nobita and Shizuka both switch to looking just like they did when he was last awake and glomp the confused cat. There is a reason the fanbase were so convinced it was canon that they were emailing the publisher asking them to verify and/or animate it.
- For those that have watched Nobita and the Steel Troops, the remake Nobita and the New Steel Troops ~Angel Wings~ has a major one near the end with a stronger impact than the original film. Lilulu had performed a Heroic Sacrifice by rewriting Amu and Emu's programming after going back in time to 30,000 years ago, thereby rewriting Mechatopia's history. As a result, she and Pippo, being of the present, Disappears into Light due to the changes. Their final lines has them sharing a scene, switching between the two. It's Heartwarming to see how far they've come from hating humans; and heartbreaking, with Shizuka desperately begging for Lilulu to not disappear and Nobita helplessly holding Pippo.
Lilulu: Shizuka... I'm glad-
Pippo: -to have met all of you.
Lilulu/Pippo: If I am reborn...
Lilulu: ...as a robot angel...
Pippo:' *happy laugh* That name... I love it...
Lilulu: ...let's be friends, okay?
- Also in Nobita and the New Steel Troops when Lilulu declares she's going to inform her commander about the gang's trickery, Nobita threatens to shoot her but can't bring himself to do it because of Pippo begging not to shoot her (as well as because of what Nobita and Pippo talked about earlier). This causes Lilulu to shoot Nobita, only for Pippo to suddenly leap in front of Nobita and take the shot himself. Nobita is then left holding an injured and unconscious Pippo in his arms horrified at what just happened, but Lilulu's reaction to this is more heartbreaking.
- Technically, each movies had good share amount of this and Crowning Moment of Heartwarming.
- Doraemon's reaction to losing his ears to mice. The fact that he's permanently blue because he's in BSOD mode makes him even more of a Woobie.
- The CGI movie Stand By Me Doraemon, whose tagline was "For anyone whose experienced childhood..." is probably the ultimate tear jerker. So much, in fact, that a poll done after its release revealed that nearly 90% of those who watched it cried. Seeing as it adapts Nobita's first meeting with Doraemon and (theoretical) farewell, why shouldn't it?!
- There is one manga story where Nobita brings a past version of himself to the present to experience having a younger brother. Then, Nobita's mother sees this and starts to question whether she had another son. After the two Nobitas have an argument and the younger self runs off to his/their mother, she breaks down crying and calls herself a terrible mother, for apparently forgetting the "younger brother." As strict as she can be, it's heartbreaking to see Tamako suffer such anguish over a matter that wasn't even her fault.