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- Bleach: the Hogyoku was originally created to eliminate the barrier between shinigami and hollow. Later, it is revealed to grant the heart's truest desires; assuming the Hogyoku is exposed to twice captain level reiatsu, and that one has the inherent potential to fulfill their wish. And then...? Aizen merged with it and was somehow granted immortality. So... either he was immortal to begin with, or had the potential to become...?
- In One Piece, some devil fruits give their user immunity to some lethal attacks. To gain such immortality, a person has to eat a devil fruit.
- Logias are immune to everything except their natural weaknesses, devil fruit weaknesses or haki users.
- Buggy is immune to slashes. Even Mihawk, the 'greatest swordsman in the world', couldn't kill Buggy with his sword.
- Brook's power is the closest to immortality of any of the fruits. After dying, his ghost was able to reanimate his skeleton body. With a lack of organs, most attacks cannot kill Brook, though he can still suffer pain and be defeated in battle. Brook can also turn into a ghost by escaping his body.
- Law's Op-Op Fruit can manipulate anything within a specific area. The only limitation is that using the Op-Op Fruit's power drains his stamina. The Op-Op Fruit is considered one of the most powerful Fruits in existence because its ultimate technique grants eternal youth to someone at the cost of the user's own life. It was for this reason that Doflamingo sought out Law after his initial defection in order to bring him back into the fold and "educate" him on the "importance" of dying for Doflamingo. Law overheard this right before Doflamingo murdered his [Law's] idol Corazon (Doflamingo's brother), putting him off any interest of ever utilizing this ability.
- The Grand Panacea from Baccano! has this effect; anyone who drinks it ceases aging and almost immediately recovers from any injury (seriously, if they're burned the ash turns right back into flesh). The only way to "kill" an immortal is for another to absorb them (which gives them their memories in the process). There's also lesser versions of it that grant invulnerability and the weakness to being absorbed but not immunity to aging.
- According to the novels, Baccano immortals are actually immune to fire and acid, not just able to recover from it. Szilard's research has shown that their individual cells are completely indestructible and anything that involved breaking down things on a cellular level such as burning (or acid), won't actually do anything to them. The damage that fire/acid does to the outer portion of their cells is so small it regenerates instantly resulting in immortals that don't give off smoke while on fire since their cells don't even have time to turn into ash, and fires that will burn literally forever as long as they have enough heat/oxygen to keep the reaction going since the immortal's body provides unlimited fuel. That's not to say it doesn't hurt them, since their nerves can still sense the heat and register it as pain.
- In Zombie Powder, various "powder hunters" search for the Rings of the Dead, which when brought together produce a substance called Zombie Powder that can be used to either raise the dead or grant immortality to the living.
- Rin and Mimi in Mnemosyne became immortal when "time spores" entered their bodies. They can sustain severe injuries and regenerate themselves fully, as is shown with the often gruesome stuff that is inflicted on Rin. There is one character in the show who actually eats time spores, preferably old ones, so Rin and Mimi still have to watch their step.
- The Philosopher's Stones in Fullmetal Alchemist. Every character laying claim to immortality possesses at least one, allowing them to regenerate from injuries (including fatal ones); however, this expends their Philosopher's Stones, meaning that a sufficiently tenacious opponent can still kill them. It's also possible to destroy their Philosopher's Stones directly through alchemy, or even rip them out as Envy does to himself after he's called on his hypocrisy. Exactly how many "lives" a Philosopher's Stone grants is dependent on how many human souls are contained within it.
- In Fairy Tail, during the Tenrou Island arc, both sides possess one.
- Samurai 7 has a ruler enthroned in a machine that prolongs his life.
- Both Yukiko and Liselotte Werckmeister from 11eyes share the same immortality that comes with an rapid Healing Factor and the inability to age. It is revealed that the Voidstone is the source of the immortality and separating it from the host will disable that immortality.
- In Jojos Bizarre Adventure, the Stone Mask created by the Pillarman Kars can grant immortality in the form of vampirism to humans. When combined with the Red Stone of Aja, the Mask can bestow Complete Immortality.
- In Dragon Ball, one of the wishes the Dragons can grant is bestowing immortality. The early villains of Z, Vegeta and Frieza, wanted Earth and later Namek's Dragon Balls for this reason. Though Vegeta only sought them out because he believed he would only be able to defeat Frieza if he was immortal. He lost interest in immortality after Frieza was defeated.
- One anthology issue of The Tomb of Dracula featured a underground pool of blood that made any mortal contacting it immortal.
- Superman & Batman: Generations: There is a pool that makes a person submerged in it immortal, but two people have to enter together and one of them will die.
- The Lazarus Pits used by Batman archfoe Ra's Al Ghul and others can rejuvenate the dying. Ra's Al Ghul is hundreds of years old thanks to the Pits.
- Marvel Comics' Ulysses Bloodstone is immortal because of a meteorite/gem shard stuck in his chest. At the end of his story, it gets surgically removed by some bad guys and he dies.
- The Sphinx, an enemy of Nova, was an Ancient Egyptian Priest given immortality and great powers by a gem he found in a mysterious temple. But he came to regret living for thousands of years; his main motivation was to find a way to end his own existence.
- Vandal Savage was a Cro-Magnon man named Vadar Adg who found a strange meteorite that fell to Earth one cold night. He fell asleep near it, being bathed in its rays during the night, and he woke up an immortal being. However, the meteorite's effects aren't permanent; Vandal occasionally needs to eat the flesh and organs of his own descendants to maintain his immortality. (That bit is Newer Than They Think, added after the appearance of the immortal character with the same weakness in Smallville.)
- Nick Fury stopped aging thanks to the Infinity Formula. His Arch-Enemy Baron Strucker is also immortal thanks to the Death Spore and other serums HYDRA used on him.
- Mammoth Mogul from Archie Comics' Sonic the Hedgehog is immortal thanks to the Chaos Emerald embedded in his chest.
- Batman: Endgame reveals that "Dionesium" is responsible for the apparent immortality and healing factors of several characters in the DC universe: Ra's Al Ghul via the Lazarus Pits, Vandal Savage, the Court of Owls' Talons, and the Joker.
- Bernadette's scythe in Death Vigil can revive the dead into members of her Vigil, which also comes with the perks of gaining a veilripper and the ability to face the Eldritch Abominations that are planning to overthrow humankind without being driven into madness.
- In the Pony POV Series:
- Becoming a Macguffin Guardian for the Rainbows of Light and Darkness comes with becoming The Ageless. This is how the Moochick lived as long as he did and how the Paradise Ponies lived for thousands of years. Patch, while regaining the pieces, was at least granted an extended life span, as while she did age it was at a very slow rate.
- The Elements of Chaos the Chaos Six possess in Dark World granted them Complete Immortality so long as the Element isn't forcibly removed while they're still whole or shattered. Given the Elements of Chaos are the fragments of the Rainbow of Darkness, this makes sense. This is implied to partly be a result of how Discord replaced their hearts with them.
- The Sirens' necklaces, in addition to massively increasing their power, also give them Complete Immortality like the Dark World Mane Six. Justified, as they're artificial Elements of Chaos.
- Tirek became immortal after absorbing the contents of Pandora's Box.
Film — Animated
- In Tangled, the magic flower and later Rapunzel's hair serve this role for Mother Gothel. Singing the magic song restores her youth.
Film — Live-Action
- The League of Extraordinary Gentlemen. Dorian Gray's portrait, as in the original novel The Picture of Dorian Gray.
- In Indiana Jones and the Last Crusade, the knight remains alive (but frail) by drinking from the Holy Grail.
- In The Age Of Adaline, Adaline stops aging after crashing her car during a freak snowstorm in the San Fransisco area, freezing to death in a river, then being struck by lightning.
- In The Last Witch Hunter, it turns out that the Witch Queen's heart is this for Kaulder - as longs as it beats, he lives.
- Animorphs: During one of their several Time Travel adventures, the team sans Jake are given this as part of two godlike characters' game. The Ellimist exploited the Exact Words of the deal Crayak made to send the gang through time to chase Visser Four. Crayak demanded one life as payment, so he only got one: once Jake was killed, the others become Jack Harkness-esque immortal, instantly reverting to normal after damage no matter how chunky salsa-ified they get.
- The Picture of Dorian Gray: the caveat is that the immortality wears off if the titular picture is destroyed.
- In Harry Potter and the Philosopher's Stone, the title object turns out to be one of these, as you might expect. It produces the Elixir of Life, which makes the drinker temporarily immortal.
- In the last book, Harry Potter and the Deathly Hallows, it's also believed that reuniting all three of the titular objects will grant immortality — becoming the "Master of Death." It turns out to be a subversion, wherein the true "Master of Death" realizes that death is inevitable in spite of the existence of magic, and that, in the end, there are far worse fates than dying.
- In Gor, humans have immortality thanks to "stabilization serums" - shots - developed by the Caste of Physicians; basically, it's an immunization against old age. In one book, a woman from Earth actually gets de-aged from her 60s to age 18 or so thanks to the serum. The priest-kings, alien gods of the planet, have even more advanced stabilization serums which make them immortal until they decide to die, although they can be killed.
- "Anti-gerosome" in Kurt Vonnegut's short story "Tomorrow And Tomorrow And Tomorrow" is a cheaply produced serum that stops ageing. This makes the world horribly over-populated, and static - one family's great-great-grandfather is still holding sway over all the descendants crammed into his home.
- The Font of Immortality (the drink, not the typing) is one of the five artifacts in Fablehaven. The catch is that it must be drank from at least once a week (don't worry, it's infinite), or else the drinker will spontaneously turn to dust.
- The Lord Ruler's bracers in Mistborn, which work due to the fact that he's a master of two metal-based magic systems which have odd interactions between them. They're made of atium which the Lord Ruler can use to store youth for later consumption using Feruchemy- with the side effect that he has to become old for an equivalent amount of time that he's young, because Feruchemy is an Equivalent Exchange system. Add his other magic system, Allomancy, which lets him draw power from the metal itself- by "burning" the bracers he's charged with Feruchemy, he's got a pair of magical objects that make him- and only him- infinitely young. This neat trick is called "compounding", and was the source of his godlike general abilities, though only the bracers are this trope.
- The mistwraiths are normal mortal creatures but once given two Hemalurgic spikes they gain sentience and become the immortal kandra.
- In Megan Whalen Turner's The Thief, Gen (the titular character) is recruited to help find a stone that grants immortality to whoever is wearing it. After he steals it, he hides it in his hair and attempts to escape, but is caught up in a fight and stabbed in the chest. When the sword is removed Gen describes it as feeling as though his life is being stretched thin by the blade, and it causes him an immense amount of pain. Gen decides the pain isn't worth it and swears off ever wanting to be immortal again.
- Durzo Blint, and later Azoth/Kylar Stern gain immortality after bonding with the Black Ka'kari from The Night Angel Trilogy by Brent Weeks.
- Wowbagger the Infinitely Prolonged from Life, the Universe and Everything gained immortality during an incident with a particle accelerator, rubber bands, and a liquid lunch. In And Another Thing..., his immortality is revoked when those same rubber bands wrap around Thor's hammer.
- The Denarians in The Dresden Files are immortal due to the presence of the Fallen contained in the silver denarius coin each one carries. Furthermore, Nicodemus is given extra protection by the fact that he wears the noose Judas Iscariot supposedly used to commit suicide around his neck, which allows him to regenerate damage that would drop even other Denarians who are protected by their respective Fallen. However, the noose itself can kill him.
- In John C. Wright's Golden Age trilogy, nomenual recordings allow effective immortality. Although it is a major plot point that the heat death of the universe will ensure that this is not actually living forever — the most that is possible is until every form of energy in the universe is completely consumed.
- In Robert E. Howard's Conan the Barbarian story "The Tower of the Elephant", Yara is said to be centuries old, and immortal because of his gem, the Heart of the Elephant.
- In Lord of the Rings, this is one of the things the One Ring can do. Gollum's unnatural age is thanks to it. The Nine for the Nazgûl also serve this function. It's not a pleasant experience however, as it makes you feel "sort of stretched, like... butter scraped over too much bread."
- In The History of the Runestaff, King-Emperor Huon's life is indefinitely prolonged by the Throne Globe, an elaborate piece of Lost Technology. From the outside, it looks like a glass sphere full of translucent fluid in which Huon floats. He can talk to people in the room, but he can't leave the sphere or move it. If it were to be destroyed, which would not be terribly hard considering it's made of glass, he would die.
- The narrator in Xanadu by Rush gains immortality after entering the Pleasure Dome, dining on the honeydew, and drinking the milk of paradise. He is not happy about it.
- In Dragonlance, Fistandantilus's bloodstone pendant allowed him to drain the life-force from other wizards to prolong his own existence. Unfortunely for him, his Bastard Understudy Raistlin figured out that he would be the next victim and turned the tables, stealing the bloodstone and using it on Fistandantilus himself, killing him, absorbing his memories and life-force, and stealing his identity to boot.
- Berem, the "Everman", has a green stone embedded in his chest granting immortality. He tried to steal it from the Foundation Stone.
- In the Old Norse Tale of Norna-Gest, the magic of a norn makes Norna-Gest immortal so long as a certain candle is not destroyed.
- In L. Jagi Lamplighter's Prospero's Daughter trilogy, Prospero and his children are immortal between the effects of Miranda's Water of Life, and Eramus's staff's ability to cure.
- In Ursula K. Le Guin's Changing Planes, one world that the narrator visits has an island which has a small population of immortals, whose eternal life is believed to be granted by the mosquitoes that are endemic there. Unfortunately, this is Type VI immortality, with a normal human ability to heal. The immortal that she is fortunate enough to meet is a withered husk after having survived falling into a lava stream. The natives don't seem to worry about this fate because, according to them, there is just one.
- Cell activators in Perry Rhodan are the Amulet of Dependency type in that once one has been worn for too long, the wearer will die from accelerated cellular decay after about 62 hours if they ever lose it. The benefits do, however, include lack of aging, a modest Healing Factor, and virtual immunity to all but the fastest-acting of poisons. The "classic" version was a literal amulet (a small egg-shaped pendant traditionally worn on a chain), which had the obvious drawbacks but also the advantage that it could be temporarily loaned to other characters to let them take advantage of its healing properties; the "modern" one is an implanted chip, which is rather harder to lose (without resorting to surgery, which some prospective thieves have tried) but also can no longer be used to help others in that fashion.
- Before the activators, there was the "cell shower" — a fairly brief and painless treatment that would stop the aging process (only) for 62 years, with chronological age presumably catching up soon afterwards if not repeated. The catch in this case was that this treatment was available only on the planet of the Sufficiently Advanced Alien who provided it to sufficiently worthy individuals, and that planet could at times prove rather elusive and was in any case eventually destroyed. (It's since been replaced at least once, but IT — the alien in question — now seems to feel that the activators are sufficient by themselves.)
- In the Star Wars Expanded Universe, there is a whole planet, Iego, that works as this. Anyone living on this planet doesn't age and doesn't need nutrition as long as they don't leave. If they leave, no ill effects happen, the biological processes just resume. Of course, the catch is that Iego is a Death World by itself, and grants no immunity to violent death.
- In Nightside a street vendor is selling immortality serum. The real deal. "One sip, and you'll live forever. note "
- Ritual from Repairman Jack novel The Haunted Air. A living child heart has to be eaten between summer solstice and the autumnal equinox every year. After 29 times user stops aging and becomes immune to harm and diseases for as long as ritual is kept up. Else...
- Glory in the Thunder: When an Aspect of the Divinity decides it has finally found the right person, it will resurrect them as an immortal when they die. They usually make rather poor choices.
- The CR (Cellular Regeneration) treatment in Captain French, or the Quest for Paradise has turned humanity into The Ageless. Overpopulation is managed both by Population Control (in the form of child licenses and easily-available and reversible sterility) and settling new worlds. People still die from violence or accidents, although We Will Have Perfect Health in the Future is also in effect. The titular character is biologically over 2000 years old, although he was born 20,000 years ago (thank Time Dilation), and was one of the first to receive the treatment (albeit quite late in life; most people do it in their 20s, while he did it in his 50s and shocks people with his grey hair).
- In Aleksandr Zarevin's Lonely Gods of the Universe, the titular "gods" are Human Aliens who have arrived to Earth thousands of years ago to escape the Big Bad. One of the first things they did was plant an herb from their homeworld called ambrosia. Surprisingly, the herb grows into a plant overnight. They make a meal with ambrosia and eat it. Suddenly, they all feel excrutiating pain and faint. Some time later, they wake up, feeling better than ever. The old professor in their group has somehow become a young man again. They find out that they have become The Ageless and have a limited Healing Factor. Unfortunately, ambrosia withers in a matter of days, although they manage to dry some of it and store it for the future (the main character ends up taking some to regrow his legs lost during a Portal Cut and become immortal). The characters become the rulers/gods to the primitive humans who live on their island, turning them into a powerful civilization with a navy that establishes colonies all over the Mediterranean. They name their island Atl-antis after their home country and the hill where their palace is built Oll-ympus after their homeworld. A security guard sent with them becomes the commander of the island's armed forces. His name? Mars Ares. The island is later sunk by a comet strike.
- Immortality in Clocks that Don't Tick was reverse-engineered from a girl whose unique mutation prevented her from growing. After throwing in super white blood cells to stave off disease, it became marketable. But it doesn't come cheap.
- In the Mediochre Q Seth Series, dragon's blood has healing and regenerative properties on living things. More than one villain has tried to exploit this in some way. Of particular note, in the first book, Maelstrom managed to survive for centuries by regularly injecting himself with the stuff.
- The Large Hadron Collider at CERN is jury-rigged to become an Immortality Inducer in Zeus Is Dead: A Monstrously Inconvenient Adventure via some material from Saturn's rings, some "really good fudge," and a few extra tweaks of Zeus's power.
- In Vladimir Ilyin's Enemies in Reason, it's eventually revealed that the so-called "black rays" that are the aliens' main weapons partly act as this to any living being they hit, while also destroying any nonliving matter in their path. It turns out that all those "galoshes" (codename for the alien Space Fighters) were actually flown by former human pilots who were made immortal. After becoming immortal, the person exhibits many signs of a corpse, such as the lack of a pulse or breathing, but is fine otherwise. Any damage appears to pass right through the person, as if he wasn't there. However, it's also discovered that a second exposure to a "black ray" reverses the process. The protagonist manages to destroy the alien craft and then spends time Walking the Earth (he's even called a "Wandering Jew" by one character).
- In Doctor Who, despite regaining a set of regenerations, the John Simm version of the Master forces himself not to, storing his essence inside a ring to revive himself later.
- Similarly, the Kastrian Eldrad was blown into a single hand. He and his entire race could store their genetic imprint into a ring to be reawakened with a burst of radiation even after over a hundred million years.
- Then there's the Time Vortex, which can do virtually anything. When Rose absorbs it, she uses it to revive the recently-killed Captain Jack Harkness. However, since she is an inexperienced "Time Goddess", she ends up reviving him permanently (essentially setting his "revive" setting to "always on"). Nothing can kill him (unless a giant vagina in Earth makes him mortal again, overriding the Time Vortex).
- Space: 1999 episode "The Exiles". Two prisoners have extended lifespans due to skintight membranes covering their bodies. If the membrane is ripped and their bodies are exposed, they're subjected to Rapid Aging and die.
- Goa'uld sarcophagi in Stargate SG-1 are best described as Autodocs, but they're so effective that they can raise the dead. The System Lords are thousands of years old thanks to them. Shame about the side effects.
- As evidenced by Lord Yu, even a sarcophagus can, eventually, prove useless, if a symbiote is extremely old. Yu is shown to be suffering from the Goa'uld version of senility, such as ordering fleets to a battle that was fought long ago. His First Prime complies, of course, but then conspires with Teal'c to turn command of the fleets over to Ba'al. Ba'al is, at first, outraged that a First Prime would betray his god, but relents after Teal'c suggests offering the deal to a rival System Lord.
- In Torchwood: Miracle Day, the Blessing is this, coupled with Jack's immortal blood.
- In Forever, while it's not entirely clear what caused Henry's Resurrective Immortality, it all started with him being shot by an 18th century pistol by a slave ship's captain (who, basically, shot his boss's son) while trying to protect a sick slave (it's later revealed that he was in the process of trying to free all the slaves on the ship). Much later, another immortal who calls himself Adam reveals his theory that the only way to stop the "curse" is to once again be killed by the same weapon that started it all. He gifts the same pistol to Henry to see if Henry has the guts to do it. Adam admits that, when he managed to re-acquire the same pugio (Roman dagger) that first killed him over 2000 years ago, he was unable bring himself to test his theory. It doesn't work, although it may be because Adam is the one who pulled the trigger, not Henry.
- House of Anubis: The Cup of Ankh functions like this under very specific circumstances. One needs to drink the elixir of life from it at "the Chosen Hour", and the cup itself must be built by The Chosen One. It once belonged to the Gods of Egypt, until Anubis' lover Amneris stole it. He got so angry that he broke it into seven different pieces, but gave the chance for it to be rebuilt- once every seventy-five years, a descendant of Amneris could rebuild the cup. The search for it, and the race to build it, is what drove the first season of the show.
- In Ragnarok Online, the Soul Linker job change implies that your character owns several.
This Witherless Rose will wither away instead of you...
This Immortal Heart will cease to pump blood, instead of yours.
This Diamond will turn to dust in place of your mortal body.
- The Fountain of Youth.
- This was said to be one of the many effects of the Philosopher's Stone.
- The ultimate goal of Chinese alchemy, rather than the western "lead into gold," was to create an elixir that granted immortality.
- For some western alchemists, the point of turning lead into gold was also to create an elixir of immortality: the the thinking was that gold is the purest metal, and transmuting the base dross of lead into gold would mean turning common flesh into angelic perfection.
- In Chinese Mythology, the Peaches of Immortality grow in the garden of the Jade Emperor of Heaven and are given to gods, sages and others deemed worthy of them.
- In Japanese Mythology, Ningyo or Mermaid flesh was said to give near infinite vitality unto the eater.
- In Greek Mythology, the food of the gods, grows on Mt. Olympus and grants their immortality.
- In Norse Mythology, the gods maintain their immortality by the eating of golden apples cultivated by the goddess Iðunn. You might be noticing a pattern here.
- The CCG Illuminati had the card Immortality Serum, which not only made the affected character indestructible, it could be played on an opponent's characters to make them defect!
- Magic: The Gathering:
- The Fountain of Youth gives players a cheap method of increasing their life points. Only the pigeons ever discovered its secrets, since no one in their right mind would drink from a dirty public fountain (especially if pigeons bathe in it).
- Elixir of Immortality is, according to its Flavor Text, literally bottled life, though somewhat stale and not particularly palatable.
- Call of Cthulhu
- Cthulhu Companion adventure "The Secret of Castronegro". Bernardo Diaz has lived for 300 years due to the ruby ring he wears. If it's removed from his finger, he will instantly die and his body will shrivel.
- The Fungi from Yuggoth adventure "By the Bay Part I". Lang Fu's Coat of Life has allowed him to live for centuries. If it is ever removed for more than a few minutes, his body will begin an irreversible aging process that will cause his rapid death.
- In Warhammer 40,000, the life of the God-Emperor of Man is preserved by technology in his throne. Probably influenced by the Runestaff books; certainly much better known nowadays. One of the signs of the Imperium's gradual decay is that the Golden Throne is starting to fail.
- Of course, the Emperor was already some 40,000 years old, sustained by his own immense psionic energies, before he was so badly wounded he needed to be placed in the Throne.
- A better example would be the Gene-seed. One of the fringe benefits of becoming a Space Marine is that you become incredibly long-lived, if not immortal. Of course, it isn't all sunshine and roses. More well-off Imperial civilians can afford the Juvenat process, which staves off aging for a few centuries.
- For Chaos Space Marines, the powers of the Warp allow you to stave off aging. Again, considering where you get the immortality from...
- The Craftworld Eldar use Soulstones to capture their souls upon death and put them into stasis note , where they're either placed in an Infinity Matrix, or a wraith construct. It's actually a pretty good deal, if you don't mind becoming either a) a ghost who will probably spend eternity giving out advice and information to the living, or b) a Golem-esque war machine who will probably spend eternity fighting the craftworld's enemies.
- The Necrons were once incredibly short-lived beings who longed for immortality. One day, they were approached by Eldritch Abominations who offered for them to be transferred into metal bodies. This turned out, of course, to be a stupendously bad idea; said horrors enslaved and brainwashed them. Nearly all of them have lost their higher-level functions and are now effectively mindless drones, and the ones who still retain free thinking and self-control are batshit insane. The Only Sane Man among them (ironically the very same lord who brokered the original deal with the C'tan) has made it his life's goal to give the Necrontyr flesh and blood bodies again.
- The Trope Namer is the +ii emitter in I Miss the Sunrise, affectionately referred to as the "immortality inducer" by some characters. It works by emitting radiation that stops cell aging, and is mass-produced, effectively making the entire human race immortal. It induces type II immortality.
- War Gods features a mystical stone known as the Ore. Induces eight humans, one cyborg and one stone idol to immortality thanks to many chunks of ore. As a result, they're fighting each other until one becomes the true superior God... (or so it seems.)
- Jacob Crow in TimeSplitters achieves immortality by merging himself with one of these, or turning himself into one, it would seem. The good? He is immortal and can time-travel at will. The bad? His body is plastered to a giant bipedal mech, and he has absolutely no hands whatsoever.
- In Metal Gear Solid 4, Vamp, who previously demonstrated his immortality in Metal Gear Solid 2: Sons of Liberty, is revealed to have nanomachines (what else?) in his body that enhance his already impressive natural healing abilities, making him practically immortal. Naturally, the only way to beat him later on is to inject him with a shot that supresses his nanomachines.
- The Touhou series has the Hourai Elixir, which was literally created by distilling the concept of eternity into liquid form. It makes whoever drinks it immortal by removing the very concept of death from their being: they will never age, never grow sick, and will heal any injury, no matter how severe (even instantly in Kaguya's case, due to her other power). The closest one can get to defeating one is beating them down until the pain makes them not want to fight you anymore. Even if you could time-travel to before they drank the elixir and tried to kill them then, it still wouldn't work; death was removed from the entirety of their history. Fortunately, only two (possibly three) people have consumed the Elixir, and not one of them is particularly interested in a fight to the death (except between two of them). The Elixir remains in the immortal's body - should someone be skilled enough to disable a Hourai immortal and eat his or her liver without cooking it, they will also be granted the effects of the Elixir.
- In Pokémon Ranger: Guardian Signs, The Societea become immortal by wearing pieces of the Golden Armor. This seems to be of the "stop the aging process and survive mortal blows" kind, but we never actually see them suffer any direct physical harm until after they lose their armor to Purple Eyes, so we can't be sure about the latter. After Purple Eyes is defeated, the armor disappears, thus making sure no one remains immortal.
- In Pokémon X and Y, the Ultimate Weapon can grant eternal life.
- The Heart of Chaos serves this purpose for Caius of Final Fantasy XIII-2. As long as it beats in his chest, he always revives instantly after being defeated, Justified via him having the Auto-Raise status boost. If it's destroyed, he dies and so does the goddess who gave it to him.
- Miss Fortune of Skullgirls, upon swallowing the Life Gem. She was cut into pieces shortly afterwards, though not only did she survive the ordeal, the gory extent of splitting apart her undying body is utilized in her fighting style.
- The Legend of Zelda:
- The Triforce of Power is stated to have made Ganondorf immortal as long as he is connected to it, although that connection can be forcibly severed.
- The Legend of Zelda: Majora's Mask: Igos du Ikana, Igos du Ikana's bodyguards, Flat, Sharp and every undead inhabitant of the Ikana Canyon revived by Skull Kid wearing the Majora's Mask and mantained alive by Twinmold.
- Mundus in DmC: Devil May Cry is an immortal demon lord in Limbo. However, the human body he uses to control events in the real world as a Corrupt Corporate Executive is as mortal as any other human. The Hellgate in his office serves the dual purposes of preventing most humans from seeing demons (Dante's psychic ally Kat is one exception) and ensuring that he is still immortal as a human. Vergil's entire plan consists of finding a way to make Mundus angry enough to leave the Hellgate unguarded so Vergil can shut down the Hellgate, exposing the existence of demons to humanity and rendering Mundus mortal.
- The Twenty-seven True Runes in the Suikoden games will stop their bearers from aging.
- However, given the nature of the True Runes, you're more likely to die just by having one.
- Dark Souls has the Primordial Crystal, which grants immortality to Seath the Scaleless, who stole it when he defected from the Eternal Dragons. Having been born without the scales that granted his species their immortality, the crystal gave him exactly what he wanted most.
- The Eye of Isis artifact in Tomb Raider III can apparently grant its bearer immortality or at least have drastically slow aging. Cosmetics tycoon Sophia Leigh posses the Isis and uses it in conjunction with her experiments to get true everlasting beauty. Unfortunately, all the people she experimented on were Left for Dead after their face and flesh rotted away and got booted down to the abandoned train tubes of Aldwych. When the men who were affected by the experiment tried to kill themselves, they discovered that it didn't work because they became immortal.
- Fallen London: The local Bazaar of the Bizarre sells these in the form of Hesperidean Cider, of which a single drink will make you immortal. It's bloody expensive, though, to the point only three players have ever managed to buy it. Plus, it isn't that much help anyways unless you want to head for the surface (or the "no death from old age" part is what interests you), as within the Neath Death Is Cheap and you'll get back up soon afterwards.
- In Battleborn, the Jennerit have a process called "Sustainment" which makes a being all but immortal. Discovered tens of thousands of years ago by Empress Lenore, the process involves harnessing the dark energies of the universe and using the Sustainment Engine, a device housed in the massive moon-sized starship Exodus, to expend enormous amounts of power in order to make a single being an immortal. This however is extremely energy-expensive, consuming stored energy on a planetary scale just to alter one being. Therefore, Sustainment isn't done often and candidates for sustainment are vetted through a rigorous process before finally being approved by the Empress herself. What's even rarer, and quite unusual, is when a member of a non-Jennerit race is allowed to become Sustained.
- Bravest Warriors has the Ever Gauntlet, which keeps its holder(s) from aging. It also halts all natural body functions, including healing, but all can be restored by just getting away from it.
- The Paradox Space story The Thirst of Dornamon Gary involves a t-shirt with a picture of Hella Jeff on it, which ages instead of him.
- The life extenders are this for their holders in the Team Fortress 2 supplemental webcomics: one for Blutarch Mann, the other for Redmond Mann. The Loose Canon comic suggested that THREE were built. In fact, there are a total of four. One is used by the lost Mann brother, Gray, assumed to be the third although later developments suggest he actually built it himself. Everything he's done since showing up is to find Australium to keep it going. The final life extender, presumably the third original, is used by the Administrator and frequently upgraded by the Engineer, as revealed by Blood in the Water. That same story however reveals that even the life extenders have their limits. The Administrator's upgraded version will still only grant her a few more years.
- From the SCP Foundation, there's SCP-963, a talisman which, if you are killed while holding it, is imprinted with your soul. From then on, anyone else who touches the talisman has their personality overwritten with whoever is contained inside. It's actually possible to make multiple copies of yourself this way.
- Unfortunately, SCP-963 currently belongs to the quite-possibly-insane Dr. Bright, which led to several (actually pretty funny) restrictions such as "SCP-963 is not a joy-buzzer.", "SCP-963 is not to be used in a game of 'hot potato'.", and "Dr. Bright is not allowed to apply SCP-963 to any major political figures. Again."
- Anyone who touches SCP-596 is kept alive forever until they release it, even regenerating from any injury. Not that you would want to be however, since you're kept alive in permanent agony, and the only way to let go is for someone else to touch it at which point it's their problem and you instantly die. Its heavily hinted that it was a booby trap to curse tomb robbers with a case of And I Must Scream.
- In Jix Kelelder the Planet Thief was made immortal due to a glitch in a cloning and mind transfer device. He's also made a couple of servants immortal using his blood, Heleatra too due to a deal with Remula.
- The Guardian Emerald in Sonic the Comic – Online! when Knuckles died, it would always resurrected him, but when then Floating Island's systems fell into disrepair most of Knuckles's memories were lost, as such he does not know the fate of his race and for it to work a being from the spiritual plane must be willing to exist in the mortal realm, unfortunately for the Echidnas, and perhaps all of Mobius, the only willing candidate was Vichama, the God of Death.
- The Dog talisman in Jackie Chan Adventures gives someone immortality with youthful energy, but (the baddies, at least) can still feel pain from blunt force trauma. The Horse Talisman could probably provide From a Single Cell-type immortality, although its regenerative powers were never taken to that limit in the show. Together, they provide Complete Immortality.
- Starscream, in Transformers Animated, becomes immortal due to a shard of the AllSpark lodged in his head. Prowl removes it in the series finale.
- In Gargoyles, Demona and Macbeth are each other's immortality inducers. As long as one is alive, the other cannot die. The only way either of them can die is if they kill each other. By the time of his first appearance in the series, after hundreds of years living this way, this is exactly what Macbeth wants.
- In Adventure Time, the Ice King's Crown grants its wearer, among other things, immortality.
- In the X-Men animated series, the secret to Apocalypse's immortality is the Lazarus Chamber, an ancient device located inside his pyramidal headquarters in Cairo. It allows him to rejuvenate himself every hundred or so years and restore his power to its prime.
- Certain mutations in genes such as BRCA 1, Rb, c-Myc et al. can prevent your cells from dying after a preset number of divisions. Unforunately, scientists call this condition cancer. So while your individual cells become immortal (the tumour cells taken from the body of Henrietta Lacks are still alive today; they will continue to live as long as the field of biology exists), but you will die.