Family Unfriendly Death: He falls into a vat of alcohol, which of course has very deadly effects on germs...although to be fair this tends to be how irredeemable villains tend to die...
Nice Job Fixing It, Villain: In the final battle with Ozzy, he use the chain holding the hypothalamus chromosome to try and choke him. But then Shane blinks, separating the two with the chain still around Ozzy's neck. His final attack failing thanks to Ozzy's morphing abilities seal the deal.
Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out a virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank.
My God, What Have I Done?: Doesn't say it but his reaction as the city of Frank burns down around him pretty much has this trope all over it.
Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and pretty much the cause of Frank's behavior. Said neglect needless to say, almost ends up killing the guy and every cell with him.
Bumbling Dad: He means well, and does care about Shane, but he has a major selfish streak. Though this is mostly due to Mayor Phlemming overriding his body for his own ends.
Too Dumb to Live: What kicks off the whole plot as he eats an egg that was inside the mouth of a monkey and got spat out onto the ground.Yeah that seems sanitary.
Vomit Indiscretion Shot: Double Subverted; we don't see it actually happen (although we hear him retching, the focus is on the horrified crowd at the science fair), but we do see a picture of him puking all over Shane's teacher.
Calling the Old Man Out: Blames Frank and his unhealthy habits for Maggie's untimely death, and calls him out for deciding to take her to a chicken wing Fan Convention instead of the hiking trip she was looking forward to.
Children Raise You: Takes care of her dad, because he doesn't take care of himself.
Deceased Parents Are The Best: Averted; she misses her mom a lot, and is rather distant from the other kids at school. Taking care of her dad doesn't help either.
Missing Mom: Her mom died of an unspecified illness.