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Osmosis "Ozzy" Jones
Voiced by: Chris Rock
- Cheshire Cat Grin: He sports one of these every now and again.
- Cool Car: Had his cop car customized.
- Cowboy Cop
- Determinator: Chases down Thrax outside Frank's body.Thrax: You just don't know when to quit, do ya, Jones?
- Dogged Nice Guy: Has trouble winning Leah Estrogen's affections. He does at the end, though.
- The Hero
- Ink-Suit Actor: He's essentially Chris Rock as a white cell.
- In-Series Nickname: Always known by "Ozzy".
- Nice Job Breaking It, Hero!: He did the right thing causing Frank to vomit, thereby saving him from a contaminated oyster, but it caused Frank to lose his job and the respect of the local community, and got Ozzy suspended for "use of unnecessary force".
- Official Couple: With Leah at the movie's end.
- Protagonist Title: For the film. In the animated series he shares the title with Drix.
- Red Oni, Blue Oni: The red to Drix's blue.
- Sensitive Guy and Manly Man: The Manly Man to Drix's Sensitive Guy.
- Sesquipedalian Smith
- Shapeshifter Showdown: What saves him against Thrax.
Voiced by: David Hyde Pierce
- Arm Cannon: How he utilizes his icy painkilling abilities.
- The Big Guy:
- But Not Too White: Drix is played by David Hyde Pierce. The producers were looking for someone as white-bread as possible. Niles Crane is about as white-bread as you can get.
- By-the-Book Cop: Part of what makes him different from Osmosis.
- Captain Ersatz: Drix bears a strong resemblance to Iron Man.
- Genius Bruiser
- An Ice Person: His painkilling abilities are portrayed as this.
- In-Series Nickname: "Drix" is this, short for Drixenol (or Drixobenzometaphedramine).
- The Lancer
- Red Is Heroic: His main colors are red and yellow.
- Red Oni, Blue Oni: The blue to Ozzy's red.
- Sensitive Guy and Manly Man: The Sensitive Guy to Ozzy's Manly Man.
- Slasher Smile: When pretending to be crazy to extract information from a flu vaccine.
- The Smart Guy: He certainly acts smarter than Osmosis, at least. To be fair, he is intelligent and educated, Ozzy just has more experience, and Drix listens to him when it is prudent to do so.
Voiced by: Laurence Fishburne
- Ass Kicking Equals Authority: He gets the bacterias to accept him as their leader after he single-handedly killed their boss.
- Badass Boast: When Scabies mocked Thrax, saying he thinks himself the Ebola Virus.Thrax: "Ebola"? Let me tell you a little something about Ebola, baby. Ebola's a case of DANDRUFF COMPARED TO ME!
- Badass Longcoat: One he can even use as a glider.
- Bad Boss: He kills all his remaining underlings when one of them suggests waiting for some days in incubation before striking.
- Berserk Button: Do not get in the way of his goal of being in the medical books. He killed all of his men when one suggests they incubate. He doesn't take kindly to being looked down on, as Scabies found out.Scabies: Look who thinks he's the Ebola virus! (laughs)
- Big Bad: He's the reason why Frank is in danger.
- Big "NO!": Does this when Ozzy traps him on the girl's fake eyelash that is about to fall.
- Bond Villain Stupidity: Rather than using his One-Hit Kill claw on a dazed Ozzy during the final battle, he decides to strangle him using his chain. This costs him big when Frank's daughter blinks: he loses his grip on the chain, and when he decides to actually use the aforementioned Touch of Death, Ozzy manages to dodge it and get Thrax stuck, sealing the virus's fate.
- Cool Shades: Owns a pair of these, and wears them frequently.
- Deadpan Snarker: Tends to make dry comments on the somewhat low quality of Frank's criminal underworld.
- Diseased Name: And a Punny Name at that, as his name is a play on the bacteria anthrax. This is a bit odd, however, considering that he is a virus and not a bacteria. It's possible that his name is purely for aesthetic.
- Disney Villain Death: Subverted. He falls, but that doesn't kill him—it's what he falls into that does. And we get to see it.
- Establishing Character Moment: The first thing he does upon being introduced is to casually murder two harmless workers, at least one in an incredibly gruesome way. He then proceeds to burn their entire boat by merely scratching its surface with his index while he is walking.
- Even Evil Has Standards: Is visibly disturbed upon seeing some of Frank's nightmares and bad memories.Thrax: (after escaping from the room) This cat was sick before I even got here!
- Evil Is Burning Hot: Thrax's immolating Touch of Death takes the form of one of his talons glowing red hot. His plan to kill Frank involves sabotaging his hypothalamus, which is the gland responsible (among other things) for regulating body temperature. One Thrax steals an important component of the hypothalamus, the temperature skyrockets and deadly fires start breaking out across the city.Thrax: "About time somebody turned up the heat in here!"
- Evil Is Petty: Only partially. Thrax wants to kill Frank in a record time so he can be in medical textbooks.
- Expy: Given his color scheme and extremely short action timespan, he's one of Edgar Allan Poe's Red Death from The Masque of the Red Death. This is given a nod via a witness calling him "La Muerte Roja".
- Fame Through Infamy: He hopes that his murders will put him in the medical textbooks.
- Family-Unfriendly Death:
- His Touch of Death has pretty gruesome results, and one of the first things he does is inflict this on an innocent cell. Said victim proceeds to boil alive from the inside out.
- Fittingly, this ends up being Thrax's own fate; he falls into a glass of alcohol and is completely incinerated.
- Faux Affably Evil: He likes to hum "Fever" by Peggy Lee and presents himself as charismatic, but this barely hides the monster he is.
- Finger Poke of Doom: Quite literally with his first victim. "Ow."
- Glory Hound: Thrax is like a serial killer who's trying to become famous in the most brutal fashion.
- Lack of Empathy: He makes everyone's suffering without any redeeming qualities whatsoever.
- Knight of Cerebus: Were you expecting a movie about Chris Rock as a blood cell to have a virus in the form of a serial killer?
- Leitmotif: "Fever" by Peggy Lee, though it's invoked because he's always humming it. The title alone suits him.
- Monstrous Germs: He is a red-skinned humanoid with tentacle-like dreadlocks and a large burning claw on one of his hands.
- Names to Run Away from Really Fast: Thrax, meant to evoke anthrax.
- Nice Job Fixing It, Villain!: In the final battle with Ozzy, he use the black chain holding the hypothalamus chromosome to try and choke him. But then Shane blinks, separating the two with the chain still around Ozzy's neck. His final attack failing thanks to Ozzy's morphing abilities seal the deal.
- Omnicidal Maniac: Thrax's plans involve killing people, causing the civilizations of cells in their bodies to die. The loss of life is apocalyptic at the cellular level, with an implied decimation among humans (since Thrax wants his own chapter in the medical books he'd likely seek to become an epidemic, which would entail massive loss of life).
- Playing with Fire: His fingernail claw burns whatever he scratches into a melting, burning lava mess.
- Red and Black and Evil All Over: Red-skinned, dressed in black, and definitely evil.
- Sadist: He revels in the pain he causes and enjoys to see his victims' suffering.
- Scary Black Man: Only in voice (Laurence Fishburne does it).
- Serial Killer: He keeps trophies from his victims and reminisces about them.
- A Sinister Clue: Only a given, since that's the hand he uses to kill all his victims and spread his infection.
- Slasher Smile: He sports quite a few throughout the movie, the most notable one being when he threatens to kill Frank's daughter.
- Soft-Spoken Sadist: He likes to keep a low tone at times.
- The Sociopath: He'll kill as many people as it takes to get into the medical books.
- Touch of Death: His left index finger causes any organic matter it touches to combust or explode.
- Vile Villain, Saccharine Show: And how. Apart from the serial killer overtones, there's his meeting the group of germs in the Zit. With the plan to organize coordinated assaults with the intention of causing widespread death and destruction, also spreading fear and intimidation outside Frank. Thrax comes across as a leader of a terrorist group planning an attack. It's jarring how such a vicious, murdering villain managed to stick in an otherwise light-hearted comedy.
- Villainous Cheekbones: Thrax's cheekbones are so pointy they look sharp, and he his clearly evil.
- Would Hurt a Child: Brags about killing a little girl - and has his sights on Frank's daughter when he's done with Frank.
Voiced by: William Shatner
- Fat Idiot: He clearly doesn't see what could happen if he keeps giving Frank junk food instead of healthy food, hence the obesity.
- Hate Sink: As he is designed to represent and justify Frank's poor health, he inevitably ventures into this. Notably, he abolishes Ozzy from the police force for making Frank throw up even though it was an emergency situation, fails to acknowledge Thrax as a threat despite the fact that he had killed others in the past (dismissing him as the common cold when he was one of the deadliest viruses ever), and is the only one that doesn't see the problem in giving Frank nothing but junk food.
- Jerkass : He certainly is, especially to Ozzy.
- Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out an evil virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank's own body.
- Mayor Pain: Though he's not corrupt per se, he's VERY incompetent at his job and cares more about his election than anything else.
- My God, What Have I Done?: Doesn't say it but his reaction as the city of Frank burns down around him pretty much has this trope all over it.
- Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and as mayor control's nearly all of Frank's actions, including his slovenly behavior. Said neglect needless to say, almost ends up killing the guy and every cell with him.
- Sleazy Politician: To the tee.
- Too Dumb to Live: His actions almost get his city destroyed.
Voiced by: Brandy Norwood
- The Chick
- Graceful Ladies Like Purple: Her suit and even her body are both purple.
- Living MacGuffin: Is taken hostage by Thrax, and very nearly killed by him.
- Non-Mammal Mammaries
- Office Lady: Works as a secretary for Mayor Phlegming.
- Official Couple: With Ozzy in the end.
- Sassy Black Woman
- She's Got Legs: That mini-skirt isn't helping the fact that she has long legs.
- The Smurfette Principle: Although Leah isn't the only female anthropomorphic cell in Frank's body, she's the only one with Nominal Importance.
- Tsundere: Type B.
- Women Are Wiser
Voiced by: David Ossman
- All There in the Manual: His name was seen in tie-in media.
- Asshole Victim: Scabies whom Thrax made short work (and short pieces) of. Also, all his germ minions.
- Big Bad: He is until Thrax killed him.
- Bullying a Dragon: Scabies didn't like Thrax's bragging and compared him to Ebola.
- Diseased Name: Scabies is named after the itching condition, but is never shown to cause it besides living in the armpit.
- Family-Unfriendly Death: He was killed by Thrax.
- No Celebrities Were Harmed: Scabies' mannerisms and voice were based on Marlon Brando from The Godfather.
- Starter Villain: Of the film.
- Too Dumb to Live: He was surprised by Thrax's sudden attacks.
Bruiser and Joe Cramp
Francis "Frank" DiTorre
Played by: Bill Murray
- Bumbling Dad: He means well, and does care about Shane, but he has a major selfish streak. Though this is mostly due to Mayor Phlemming overriding his body for his own ends.
- Children Raise You
- "Fantastic Voyage" Plot: The plot takes place inside Frank's body
- Fat Idiot
- Guys Are Slobs: Played straight and subverted, as in a flashback we hear Shane complain that neither he or Maggie, his wife, take care of themselves very well, Frank just got worse after Maggie died.
- The Mourning After: Still mourning the loss of his wife, Maggie. Justified, as it seems to be a relatively recent loss.
- One of the Kids
- Straw Loser
- Too Dumb to Live: What kicks off the whole plot as he eats an egg that was inside the mouth of a monkey and got spat out onto the ground. Yeah, that seems sanitary.
- Vomit Indiscretion Shot: Double Subverted; we don't see it actually happen (although we hear him retching, the focus is on the horrified crowd at the science fair), but we do see a picture of him puking all over Shane's teacher.
Played by: Elena Franklin
- Broken Bird
- Calling the Old Man Out: Blames Frank and his unhealthy habits for Maggie's untimely death, and calls him out for deciding to take her to a chicken wing Fan Convention instead of the hiking trip she was looking forward to.
- Children Raise You: Takes care of her dad, because he doesn't take care of himself.
- Gender-Blender Name: Her first name is predominantly used by boys.
- Missing Mom: Her mom died of an unspecified illness. Though it's implied she was as unhealthy as Frank has been throughout the movie.
- Only Sane Woman: Shane often has to be the adult between her and her father.
- Women Are Wiser