Characters / Osmosis Jones

Main characters

Osmosis "Ozzy" Jones
Voiced by: Chris Rock

Voiced by: David Hyde Pierce

Movie characters

  • Ass Kicking Equals Authority: He gets the bacterias to accept him as their leader after he single-handedly killed their boss.
  • Badass: Thrax might be a horrible, sinister individual, but there is no denying he is good at what he does. Aside from his bodycount, he is shown to have great fighting skills, easily defeating a bunch of bacteria and their boss.
  • Berserk Button: Do not get in the way of his goal of being in the medical books. He killed all of his men when one suggests they incubate.
  • Big Bad: He's the reason why Frank is in danger.
  • Dangerously Genre Savvy: He is highly aware of how to operate so that an immune cell system can never find him until it's too late. And when one does, well...
    Thrax: Oh, they're making this too easy! You know, in all the bodies I've been in no one has ever gotten wise to me. And now, for the first time, an immunity cell has figured out everything and they don't believe him!
  • Deadpan Snarker
  • Establishing Character Moment: The first thing he does upon being introduced is to casually murder two harmless workers, at least one in an incredibly gruesome way. He then proceeds to burn their entire boat by merely scratching its surface with his index while he is walking.
  • Even Evil Has Standards: Is visibly disturbed upon seeing some of Frank's nightmares and bad memories.
    Thrax: (after escaping from the room) This cat was sick before I even got here!
  • Evil Is Petty: Only partially. Thrax wants to kill Frank in a record time so he can be in medical textbooks.
  • Family-Unfriendly Death: He falls into a vat of alcohol, which of course has very deadly effects on germs... although to be fair this tends to be how irredeemable villains tend to die...
    • Also applies to the first cell he kills. What he does to the bacteria mob boss too, though to a lesser degree.
  • Faux Affably Evil: He likes to hum "Fever" by Peggy Lee and presents himself as charismatic, but this barely hides the monster he is.
  • Glory Hound: See Evil Is Petty. Thrax is like a serial killer who's trying to become famous in the most brutal fashion.
  • Kill It with Fire/Playing with Fire: His finger-nail claw pretty much burns whatever he scratches to a melting, burning lava mess.
  • Knight of Cerebus: Were you expecting a movie about Chris Rock as a blood cell to have a virus in the form of a serial killer?
  • Nice Job Fixing It, Villain: In the final battle with Ozzy, he use the black chain holding the hypothalamus chromosome to try and choke him. But then Shane blinks, separating the two with the chain still around Ozzy's neck. His final attack failing thanks to Ozzy's morphing abilities seal the deal.
  • Omnicidal Maniac: Thrax's plans involve killing people, causing the civilizations of cells in their bodies to die. The loss of life is apocalyptic at the cellular level, with an implied decimation among humans (since Thrax wants his own chapter in the medical books he'd likely seek to become an epidemic, which would entail massive loss of life).
  • Red and Black and Evil All Over: Red-skinned, dressed in black, and definitely evil.
  • Scary Black Man: Only in voice (Laurence Fishburne does it).
  • Serial Killer: He keeps trophies from his victims and reminisces about them.
  • Soft-Spoken Sadist: He likes to keep a low tone at times.
  • Vile Villain, Saccharine Show: And how. Apart from the serial killer overtones, there's his meeting the group of germs in the Zit. With the plan to organize coordinated assaults with the intention of causing widespread death and destruction, also spreading fear and intimidation outside Frank, Thrax comes across as a leader of a terrorist group planning an attack. It's jarring how such a vicious, murdering villain managed to stick in an otherwise light-hearted comedy.
  • Villainous Cheekbones: Thrax's cheekbones are so pointy they look sharp, and he his clearly evil.
  • Walking Wasteland/Touch of Death: His left index finger causes any organic matter it touches to combust or explode.
  • Would Hurt a Child: Brags about killing a little girl - and has his sights on Frank's daughter when he's done with Frank.

Mayor Phlemming

Voiced by: William Shatner
  • Fat Idiot: He clearly doesn't see what could happen if he keeps giving Frank junk food instead of healthy food, hence the obesity.
  • Hate Sink: As he is designed to represent and justify Frank's poor health, he inevitably ventures into this. Notably, he abolishes Ozzy from the police force for making Frank throw up even though it was an emergency situation, fails to acknowledge Thrax as a threat despite the fact that he had killed others in the past (dismissing him as the common cold when he was one of the deadliest viruses ever), and is the only one that doesn't see the problem in giving Frank nothing but junk food.
  • Jerkass : He certainly is, especially to Ozzy.
  • Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out an evil virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank's own body.
  • Mayor Pain: Though he's not corrupt per se, he's VERY incompetent at his job and cares more about his election than anything else.
  • My God, What Have I Done?: Doesn't say it but his reaction as the city of Frank burns down around him pretty much has this trope all over it.
  • Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and as mayor control's nearly all of Frank's actions, including his slovenly behavior. Said neglect needless to say, almost ends up killing the guy and every cell with him.
  • Sleazy Politician: To the tee.
  • Too Dumb to Live: His actions almost get his city destroyed.

Leah Estrogen

Voiced by: Brandy Norwood

Francis "Frank" DiTorre

Played by: Bill Murray

Shane DiTorre

Played by: Elena Franklin