Characters: Osmosis Jones

Main characters

Osmosis "Ozzy" Jones

Voiced by: Chris Rock

Drix

Voiced by: David Hyde Pierce

Movie characters

Thrax

Mayor Phlemming

Voiced by: William Shatner
  • Fat Idiot
  • Jerkass
  • Laser-Guided Karma: Abolished Ozzy for having Frank throw up to get out an evil virus. Then at the end when he's been booted out of office, he presses a similar button and winds up flushing himself right out of Frank's own body.
  • Mayor Pain: Type B.
  • My God, What Have I Done?: Doesn't say it but his reaction as the city of Frank burns down around him pretty much has this trope all over it.
  • Obstructive Bureaucrat: Let's see, he fired Osmosis and gets Drix out of Frank just for popping a pimple without permit (Which is like blowing up a building in the real world) and as mayor control's nearly all of Frank's actions, including his slovenly behavior. Said neglect needless to say, almost ends up killing the guy and every cell with him.
  • Sleazy Politician: To the tee.
  • Too Dumb to Live

Leah Estrogen

Voiced by: Brandy Norwood

Francis "Frank" DiTorre

Played by: Bill Murray

Shane DiTorre

Played by: Elena Franklin