"Your Momma says 'Hi.'"- Frank to Shane after his near-death experience.
Ozzy's speech to Drix about sugar pills that believed in themselves, sure it may have been made up, but like he said.
Ozzy finally earning the love from the cell of his dreams and getting a kiss from her to boot.
Leah: Come here, baby. I'm still Jonesin' for a little more osmosis.
At the ending:
Drix: Um, [Mayor]? If it's all the same to you, I think I'll stay with Jones.
Also at the ending, where Frank is hiking with Shane. He's out of breath, he's tired, he's not feeling well, and he needs a break before they can go back down...but he's trying to be healthier for her.