These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Osmosis Jones
Complete Monster: Thrax, a sinister virus obsessed with fame and breaking records in the medical books. To this end, Thrax infiltrates humans and sees how fast he can murder them. Upon arriving in the human Frank, in whose body most of the film takes place, Thrax sets about gruesomely murdering whoever crosses his path, while making Frank sicker and sicker. This has the benefit of killing not only Frank, but every being living within him. Thrax even threatens the titular protagonist, Osmosis Jones, that after Frank is dead, Thrax will gladly go and break his new record on Frank's young daughter.
Thrax declaring that "Ebola is a case of dandruff compared to me!" is made somewhat funnier by the arrival of Z Mapp, Ebola's highly tentative cure. Could also be "Funny Aneurysm" Moment after the Ebola 2014 break out.
Ho Yay: Jones and Drix. I think I'd like to stay with Jones indeed.
Foe Yay: "You know what, Jones? You want this chain so bad, Big Daddy Thrax is gonna let you have it!" Indeed.
Hollywood Pudgy: There are lines in the script that seem to imply that Shane is overweight. It seems likely that was the original intent and they never changed the script, because the actress they wound up casting is a tiny thing.
Narm: Uncle Bob's reaction to Frank getting hospitalized. His "crying" honestly sounds like hooting laughter.
Nausea Fuel: Most of the movie. Also, the scene with the zit.
Nightmare Fuel: Frank starting to die, both from his perspective and perspective of the inhabitants of Frank City.
For that matter, Red Death. He's killed several people before by stealing a part of the hypothalamus that controls body temperature, showing off a piece of jewelry with several of these bits. The thought of having a sudden, uncontrollable fever that will only go higher as time passes by...
Not that he didn't deserve it, but Thrax finds out the hard way that alchohol is like sulfuric acid to germs. Ouch.
Paranoia Fuel: There's a lot in this film. Firstly, your body is made up of millions of fully conscious Cell Individuals; talking, crying, and living their millions of lives within you as you live about yours. Every time you cut yourself and blood drips out, that's a couple thousand people dying! Also, related to the Fridge Horror, your Mayor (with approval from City Counsel) has the ability to take over your brain and make you say and do things beyond your control.
Ship Sinking: Osmosis x Leah goes down the drain when you include the spin-off show where Osmosis and Drix are forced out of Frank and transferred to a different body.
Frank picks up a hardboiled egg and eats it. What makes this Squick? The egg has been on the ground in a filthy chimpanzee cage, and before that it was IN THE CHIMP'S MOUTH. Maybe all his unhealthy habits were affecting his brain?
It's more like the Mayor thing running his brain affected his unhealthy habits.
A horror film playing in Frank's movie theater (i.e. a nightmare from his subconscious) involves his daughter marrying his brother.