- Complete Monster: In a series where The Black Death runs rampant, these two are far worse than the rats:
- Vitalis Benevent is the Grand Inquisitor with the intent of acquiring the Macula to conquer the world. Believing himself as almighty, Vitalis had his forces hunt Hugo de Rune to acquire his blood and perfect it, to acquire the power of the plague and to prolong his own life. To that end, he had many people killed and tortured, including Rodric's father after they became of no more use to him, with Beatrice de Rune kept and tortured to gain her knowledge of the Macula. Once he managed to get the Macula after sacrificing legions of his own men, Vitalis tried to tie up all loose ends by corrupting Hugo to become his follower and get him to kill Amicia. When Amicia and Hugo confront Vitalis into the headquarters of the Inquisition to stop him, Vitalis revealed that he managed to breed numerous rats under his own control and intend to use it take over all of Europe, believing he himself is humanity's savior, sacrificing an entire congregation to his powers. Power-hungry and ruthless, Vitalis plunged the world to a dark era of the plague to reach absolute power.
- Sir Nicholas is a knight who butchered countless people in the mission given to him by Vitalis. In charge of capturing Hugo de Rune, Nicholas led the massacre of the de Rune household, killing even the helpless servants and torturing Beatrice, the matriarch of the de Rune family. When the plague began to rise, Nicholas headed the Inquisition to kill countless villagers, even those who weren't infected, and abandoned many of his own men to the mercy of the plague, silently enjoying the slaughter. Once the Inquisition was able to grab hold of Hugo, Nicholas had his own men sacrificed to overtax Hugo's power to keep him in check and strengthen Vitalis's own power. With Hugo at his side, he accompanies him to attack Château d'Ombrage and tries to coerce him to murder Amicia with his rats. When Hugo resisted, Nicholas takes a hands-on approach, killing Arthur before trying to kill Amicia personally.
- Evil Is Cool: Sir Nicholas due to him being a badass knight dressed in slick black armor. Many people even call him a medieval Darth Vader. One has to admit that lighting himself on fire in order to fight Hugo's rats is quite impressive, if completely deranged.
- Harsher in Hindsight: This game deals with the the Black Death, and one of the early levels have the protagonists in a village where everyone is either quarantined, or been forcibly evicted, on the cover of limiting the spread of the plague. This gets a lot harder to look at now that the coronavirus pandemic has broken out.
- The sequence where Amicia and Hugo have to escape from their home while seeing enemy soldiers killing and brutalising their friends is meant to be harrowing, but the effect is somewhat spoiled by the oddly obliging way that enemies keep turning their backs to the only path through the house and then just standing there, apparently so fascinated by the decor that they don't notice a pair of kids walking past two steps away from them. It's partly justified in how the sequence amounts to a stealth tutorial, but could have been pulled off less obviously.
- In the back half of the game, the rats learn a new trick - they "regroup" as the game calls it and turn into churning rat tornadoes that slowly drift towards you that you must disperse with Ignifier. It's extremely silly in a game that is otherwise as serious as it can be.
- Amicia being a One-Hit Point Wonder is logical 99% of the time, considering her enemies are men with swords, shields and sometimes full plate armor. Not so logical when she goes down in one tap to the gaunt Inquisitions alchemists, who look about 90 pounds soaking wet.
- They Wasted a Perfectly Good Plot: Amicia reacts with horror to her first kill, and the game seems to be setting up a fairly realistic depiction of how killing can profoundly change someone, especially if they're only a child and even if it may be justified. However, while Amicia does become less averse to using lethal force as the game progresses, her personality doesn't otherwise change much, nor does this ever really affect the story.
YMMV / A Plague Tale: Innocence