- Acting for Two: Terence Zdunich plays both the Graverobber and the Repoman at the beginning.
- Actor-Inspired Element: Paris Hilton supplied most of Amber's clothes from her own wardrobe. The support group members wore her clothes too.
- Awesome, Dear Boy: The reason Sarah Brightman agreed to do it was that it was something way out of her comfort zone and sounded like fun.
- Box Office Bomb: Despite the $8 million budget, the film only grossed $182k in its very limited release. It has however found success as an underground film - with many calling it a modern version of The Rocky Horror Picture Show.
- Contractual Purity: Alexa Vega had been a child star in the Spy Kids franchise and her teen work had been light fare like Sleepover and Odd Girl Out. This marked a darker role for her, and Shilo fittingly is an Innocence Lost character.
- Cut Song: "Come Up and Try My New Parts", among others.
- Dawson Casting: Shilo is seventeen, played by Alexa Vega at twenty.
- Doing It for the Art: Paris Hilton was denied an audition at first, Darren Lynn Bousman afraid that she wouldn't be able to do it and that the media would attack him for Stunt Casting. He eventually gave in and she came to the audition dressed "perfectly for the part" and nailed the sound booth audition.
- Follow the Leader: It's not Baz Luhrmann, but an incredible simulation!
- No Budget: Made for just $8.5 million.
- Science Marches On: Some science fiction/speculative fiction fans try and take this movie to task for its depiction of organ transplants 50 years in the future being implausibly efficient by today's standards, forgetting that the idea of ANY kind of artificial organ transplant was science fiction 50 years ago.
- Serendipity Writes the Plot: The band members of the Genetic Opera wear masks because the film originally only had twenty extras, and this disguised the fact.
- Stillborn Franchise: Word of God is that the film is the middle part of a trilogy. The next film would have been a prequel titled Repo: The Beginning. The creators later revealed they no longer had ownership of the franchise, leading them to make a Spiritual Successor in The Devil's Carnival.
- What Could Have Been:
- Sarah Brightman replaced another actress who dropped out.
- The song "Genetic Repoman" was originally not supposed to be filmed. When producers weren't around, Darren Lynn Bousman quickly filmed Terence Zdunich singing.
- George A Romero was asked to cameo but couldn't make it.
- The film was originally going to be Direct-to-Video but got a limited theatrical release.
- The Wiki Rule: The Repo! Wiki.
- Word of God: There is a LOT of facts and background behind the characters that never made it into the final cut of the film, or even the deleted scenes. Such as apparently the holographic image of Marnie is actually not a projection, but a window looking into her preserved corpse hidden inside the wall. Or that Blind Mag's replacement eyes were taken from Marnie's body... somehow, despite Nathan preserving and stuffing her away in his wall in secret.
Trivia / Repo! The Genetic Opera