- Actor-Inspired Element: Johnny Depp was deeply involved with the story design, frequently meeting the writers to show what he was interested in doing, and in the words of Rossio, being "involved in coming up with story lines, connecting characters, creating moments that we would then fashion, shape and then go back." Among Depp's suggestions were turning Phillip into a missionary and having a Spanish contingent following the protagonists.
- Awesome, Dear Boy: Penélope Cruz was the only choice for the role of Angelica. She agreed to the role without reading the script.
- Banned in China: The film was denied a release in China because the story line consisted of ghosts, the afterlife, and the supernatural.
- B-Team Sequel: Gore Verbinski was unable to return as director due to his commitment to Rango.
- California Doubling: Location shooting on the previous films was in the real Caribbean. To keep the budget lower, this one was mostly in Hawaii, with some scenes also in Puerto Rico and... California.
- Follow the Leader: Sort of a crossed example. After the success of Spanish swashbuckling TV series Águila Roja, another company decided to try luck with a pirate-themed series appropriately named Piratas, and they gave the main role to Óscar Jaenada for his work in On Stranger Tides (where he plays The Spaniard).
- Hide Your Pregnancy: Penélope Cruz. Thank God for elastic corsets and puffy shirts. (The scene where her character seeks clemency by claiming to be pregnant may have been added as Reality Subtext.) For some of the more intensive stunt and sword work, her younger sister Monica filled in.
- Prop Recycling: The Queen Anne's Revenge was built atop the same ship that was the Black Pearl in the previous movies.
- What Could Have Been:
Trivia / Pirates of the Caribbean: On Stranger Tides