- Actor Allusion:
- Once again, Ben Browder has a malevolent AI contained within a neural implant controlling his actions and overriding his senses with trippy digital fantasies.
- Katee Sackhoff once again plays a cybernetic-enhanced soldier who's gone rogue thanks to her implants; interestingly, the virus infecting her is named Corvus, which was the surname of her last corrupted cybernetic character. Additionally, both Sackhoff's cybernetic characters are named Sarah.
- Celebrity Voice Actor:
- The campaign stars Christopher Meloni, who voices the campaign's antagonist John Taylor, and Katee Sackhoff who plays Action Girl Sarah Hall. There's also a blink and you'll miss it cameo from Seattle Seahawks running back Marshawn Lynch.
- The zombie mode stars Heather Graham, Neal McDonough, Ron Perlman, Robert Picardo, and Jeff Goldblum.
- The Danza: Rachel Kane is played by Rachel Kimsey.
- One of the first allied soldiers that appears in the World War 2 sequence is named Patterson. It may simply be a coincidence, except the setting strongly suggests otherwise and the character has the same name on every playthrough, even though minor NPC soldiers usually have randomly generated names.
- Some of the most Mind-Screwy parts of the games notably Sarah Hall's Dying Dream and the final mission, which involve things like swimming through rivers of blood, fighting monsters while surrounded by fire, and being haunted by a ghostly apparition are very reminiscent of First Encounter Assault Recon. It also bears heavy resemblance to many of the inner-mind sequences and abstract imagery seen in Neon Genesis Evangelion, complete with similar themes of transcendence and rebirth.
- Several of the accolades that can be earned throughout the Campaign: Epic R.A.P.S. Battle, Way of the Fist, and I now know why you cry, to name a few.
- One of the available pistols (the MR 6) resembles the Lawgiver of the film versions of Judge Dredd (the frame from the Stallone movie with the digital display on the side from the Karl Urban film).
- You Look Familiar: Robert Picardo, who previously voiced Robert McNamara in the original Call of Duty: Black Ops and Erik Brieghner in Call of Duty: Black Ops II, returns to play Sebastian Krueger in the campaign and the Shadow Man in Zombies.
Trivia / Call of Duty: Black Ops III