Adults Are Useless: Played straight as no one else seems willing to take on the Ministry even though they clearly aren't much of a threat anymore. Ultimately subverted though as when the Powerpuff Girls fail to deal with them themselves, the Ministry along with Captain Righteous and Lefty are all injured in their fight, and the paramedics immediately arrive to rush all of them to the hospital. Thankfully, their quick timing meant the five men would eventually recover.
Big "NO!": Captain Righteous lets out a big no as he runs towards Lefty who just hurt his hip. However, he hasn't reached his sidekick yet so he shouts it again.
The Determinator: Despite their age, Captain Righteous and Lefty do succeed in finding and confronting their old foes, with the former even managing to fly all the way to the crime scene. It quickly goes downhill from there though.
Dirty Coward: The Mayor, unsurprisingly. He is especially ignorant of how old the once-dangerous Ministry of Pain has become, and is quick to assume that Townsville is doomed despite the evidence to the contrary.
Downer Ending: A rare case where the girls actually failed to save the day, a fact that even the Townsville news points out at the end.
Epic Fail: Five incredibly old people try to have a superhero fight. They are all so old that they can barely walk. What results is something that could only charitably be called a Wimp Fight and which puts all of them in the hospital for varied reasons (like their hips giving out on them).
Evil Old Folks: "The Ministry of Pain", a supervillain team that used to terrorize Townsville but are now mostly harmless because they've become old and feeble. They're still as evil as ever, though, and Blossom tells her sisters that they won't fight them because they need to respect their elders.
Heroic Sacrifice: Captain Righteous is so horrified at Lefty's broken hip that he flies right into the Ministry of Pain before they can escape. Everyone pulls through, but only after they are hospitalized for their troubles.
Honor Before Reason: Blossom refuses to hurt elderly people, even if they are criminals. Because of this, she then decides to contact the heroes that used to fight The Ministry Of Pain (now equally old and having long since had a fall out). The resulting Epic Fail puts everybody (from reporters to her sisters) to deliver a What the Hell, Hero?.
How the Mighty Have Fallen: As determined as Mastermind might be, him and his two lackeys can't do anything more than steal money from the local banks in their old age, which they use to escape scot-free. Captain Righteous and Lefty are also this, not just because of their old age but also because of a massive falling out that left them unwilling to work together.
Idiot Ball: Blossom suffers this big time here. She won't let the girls defeat the villains of the episode because they're adults, despite the fact the girls have already done so themselves before.
Kick the Dog: The press is very quick to place blame on the Powerpuff Girls for failing to do anything to stop the Ministry of Pain before the fight that left them and their former foes injured; Buttercup and Bubbles are just as quick to remind Blossom of how foolish her plan was.
Large Ham: Mastermind, also Captain Righteous to a lesser extent.
My God, What Have I Done?: Blossom's face just screams this when her sisters glare at her after her plan backfires, sending all five men to the hospital.
Mythology Gag: The exterior of Pokey Folks retirement home is what used to be the Hanna-Barbera studio. The numerical address seen is 3400, and the studio was at 3400 Cahuenga Blvd. in Hollywood.
Nice Job Breaking It, Hero!: Blossom's plan to avoid harming the elderly Ministry of Pain was to send equally elderly superheroes to deal with them; it ends up causing all five of them serious injury anyway.
Old Superhero: Captain Righteous and Lefty, who have come out of retirement to stop their old foes.
Reality Ensues: The advanced age of both the Ministry of Pain and their superhero rivals quickly proves their downfall by the end of end of the episode, unsurprisingly.
Shout-Out: Captain Righteous and Lefty are a not so subtle reference to Batman and Robin, while Captain Righteous also wears an outfit that vaguely resembles that of Captain America.
Stating the Simple Solution: Despite Bubbles and Buttercup pointing out that they could easily take them, Blossom refuses to let them fight the Ministry of Pain on the grounds that they have to "respect their elders," and instead decides to talk the Ministry's equally elderly archenemies, Captain Righteous and Lefty, out of retirement to do the job for them. The end result: all five old men end up hospitalized, and the local news outright states that the entire mess could have been avoided if the Powerpuff Girls had just stepped in and stopped the Ministry of Pain in the first place.
We Used to Be Friends: Captain Righteous and Lefty; the former things his sidekick just wanted the glory in crimefighting, while the latter feels he was treated as a liability. The two eventually reconcile.....but only after getting talked into a fight that left them and their archenemies badly injured.
Would Harm a Senior: Bubbles and Buttercup are more than willing to stop the Ministry of Pain, but Blossom refuses to let them because they have to respect their elders.
Although the girls could have very easily taken the Ministry to jail without hurting them.
The Mane Event contains examples of:
Actually Pretty Funny: The Professor convinces Blossom to laugh along with everyone, and it works for her, as the Monster is laughing so hard that its eyes are all shut, giving the girls the chance to knock it into space.