Stewie attempts to get Brian's life on track by swapping bodies with him, but the machine soon causes havoc around town.
Examples:
- The Alcoholic: Chris (in Brian's body) has the overwhelming urge to drink at 10:30 AM. When Chris asks Brian (in Chris's body) about this, Brian retorts that he has the urge to eat Cheetos and masturbate in the woods.
- Bolt of Divine Retribution: When Brian is at the top of the Quahog cell phone tower to recharge the body swapper, Stewie tells Brian he has to get struck by lightning. When Brian asks how, Stewie reminds him that he's an atheist and tells him to offend God. "Say something you couldn't say on TV." Brian promptly looks heavenward and launches a Cluster Bleep-Bomb. However, God does not respond and lets Hindu god Indra take over.
- Borrowed Catchphrase: Bruce and the Kool-Aid Man say the other's catchphrases ("Oh noooo!" "Oh yeah!"). Justified because they've switched bodies. Same goes for several other characters.
- Brick Joke:
- When Brian switches bodies with Stewie, the latter ends up licking Brian’s crotch like a regular dog and says to him “What the hell have you been complaining about?” Later, when Chris switches bodies with Brian, he also licks his codpiece and asks the same question.
- When Stewie (in Peter's body) calls Brian to tell him about Lois wanting sex, Brian states the plan is to have him switch into Peter's body which Stewie shoots down. After Brian and Chris activate the machine to switch everyone back at the end, Lois jumps "Peter" before he can say anything. Post-coitus, Brian's voice comes out.
- Call-Back: The ending short of people in Quahog having their bodies switched ends on a graveyard with Diane Simmons and Muriel Goldman’s graves with a subtitle saying they switched bodies. The graves allude to the fact that they both died in the hour-long special ‘And The There Were Fewer’. For bonus points, their graves said they died in 2010, which is the year that the special aired on.
- Comically Missing the Point: Stewie (in Brian's body) assumes a prostitute is trying to eat him when she starts performing oral sex on him.
- Conflict Ball: The Plot-Driven Breakdown is caused by Chris insulting Peter for no apparent reason, inciting that moves from the hallway into the machine as Stewie activates it.
- The Dog Bites Back: Quagmire was going to shove a gerbil up his butt, which the Gerbil was most likely against. However, when they swapped bodies, Quagmire ends up on the receiving end when the Gerbil giddily sticks him up his butt.
- Double Standard Rape: Female on Male: While Lois couldn’t have known that Stewie was in Peter’s body, she seems disturbingly oblivious toward his clear aversion to sex, even when she’s smashing through the bathroom door that he locked himself behind. The episode presents this as more of an issue regarding the impending trauma for her baby son than the fact that she’s acting this way at all.
- "Freaky Friday" Flip: Name-dropped by Tricia and Ollie.Tricia in Ollie's body: What kind of a Friday is this?
Ollie in Tricia's body: FREAKY! - Freeze-Frame Bonus: According to the sign on the Weekapaug Inn that only appears during the first establishing shot, tomorrow's event is "CONGRATULATIONS, YOU'RE A FAST READER".
- Halfway Plot Switch: The episode starts with Brian falling in love with an a virtual assistant named Brandee and spending all his money on ordering things using her. After his maxes out his credit cards and Brandee gets taken away, Stewie offers to help him out of his depression, kicking off the main "body-swap" plot.
- Hoist by His Own Petard: Quagmire was going to shove a gerbil up his ass, but when he switches bodies with the gerbil, Quagmire gets the short end of the stick.
- Hypocrite: Stewie usually gets on Brian’s case about the latter’s pretentious tendencies. However, he soon makes himself look like an egotistical fool when trying to teach the poetry class at the college while in Brian’s body.
- Laser-Guided Karma: After nearly traumatizing her own son, Lois ends up getting unsatisfied after having sex with Brian in Peter's body.
- Last-Second Photo Failure: In one cutaway, Stewie rudely interrupts a family's on-ride photo and argues with the father when asked to get out of the way. Defying this, Stewie then decides to stand on top of the ride vehicle. Leading to his head landing onto another family's ride vehicle as the picture is taken.
- Layman's Terms: During the scene where the body swapper is being fixed by Brian (who is guided by Stewie via phone):Stewie in Peter's body: All right, now you got to reverse the voltage orientation and amplify the electron flow to the motherboard.
Brian in Chris's body: Stewie, just say it in English or so help me God, I will hang up and make you screw your mom.
Stewie in Peter's body: Switch the black and yellow wires! - Mirror Routine: To stop Peter-in-Stewie realising what has happened to him, Stewie-in-Peter pretends to be Peter's reflection in a mirror (actually an open door).
- No Ending: The episode ends with Brian managing to swap with Peter's body, who has Stewie's mind trapped in it, saving him from Lois. However, the episode offers no resolution for the rest of Quahog.
- Plot-Driven Breakdown: The tendency of Stewie's inventions to go through this is lampshaded by Brian. Stewie claims his Particle Interchange Transporter won't.
- Recycled Premise: The plot is extremely reminiscent of a PowerPuff Girls episode where one of Prof. Utonium's inventions has a glitch and mind-swaps everyone in town.
- Ridiculous Repossession: After Brian goes crazy with his spending and unable to pay it back, the credit card collectors come to repo his items. As they also take Brandee, a purchase Brian notes was by Peter and not him, the guy taking her away tells Brian he's been looking for one of the devices for himself.
- Scary Black Man: The pimp.
- Shout-Out: Quite a few:
- A sex-crazed Lois references the famous "Here’s Johnny!" scene from The Shining when she uses an iron to burst through the bathroom door to get to Stewie (who was in Peter’s body).
- When Jerome switches bodies with Ida Quagmire, he wonders if he’s "doing a Madea".
- When Stewie teaches a college class while in Brian’s body, he urges them to rip out the introduction page in a poetry book.
- The popcorn trick Peter tries to do in order to touch his penis is from the film Diner.
- Swapped Roles: A lot of quick gags are made of characters switching around and having their Catchphrases contrasted. There's also Quagmire switching with the gerbil he was about to shove up his ass, who continues to do so with him.
- Take That!:
- The review for The Hangover Part III says: "I walked out of the theater, and I'm Ed Helms."
- Yoko Ono is thoroughly trashed for looking like the girl from The Ring and singing terribly.
- Techno Babble: To reverse the body-swapping procedure, Brian has to switch the black and yellow wires. Stewie's explanation is so technologically complex that Brian tells him to say it in English or he's hanging up the phone.
- Throw the Dog a Bone: After 15 seasons of teasings, Brian finally has sex with Lois when he ends up in Peter's body.
- Voices Are Mental: Invoked:Stewie: Now, the instructions gave me a couple of options. I chose the one where my voice will be coming from your body, and vice-versa.
- Worst News Judgement Ever: When Peter first shows off Brandee to the family, he asks for it to tell her the top news story, which is apparently, "Prince bred purple dolphins". In response, Stewie immediately asks, "Wasn't there a senator shot this morning?"
