The core cast of Eccentric Townsfolk is responsible for the show’s fanbase, but many recurring or one-shot characters have also won over fans in a big way.
- Loudmouthed Multiple-Choice Past hermit and Supreme Chef Adam only appears in 10 out of 110 episodes but is one of the show's most beloved characters.
- Adam's hot-headed hypochondriac wife Eve only appears in three of his episodes (plus two solo appearances) but has a very respectable fanbase of her own and her actress won an Emmy Award for her debut appearance.
- Curmudgeonly Hunter Trapper and ex-businessman Walt and the comically shifty but somewhat insightful Lovable Rogue Hayden both only appear in the last couple of years of the show in initially minor roles, but quickly became series mainstays.
- Chris's half-brother and "spiritual doppelganger" Bernard can attract just as much praise as Chris on the rare occasions he shows up.
- Ranger Burns, who mans the isolated fire watch tower, delights fans in his two episodes.
- Medicine man and totem pole sculptor Leonard (Graham Greene (Actor)) is only in five episodes, but his insightful and layered character makes him a rare twentieth-century Magical Native American character who can really sell the role.
- Ed's herbalist Cool Uncle, Anku, only appears a couple of times but is pretty well-remembered for his mixture of insightful tribal wisdom and comprehensive knowledge of the world outside of his hometown, as well as his willingness to consider both sides during arguments.
- Maggie's Control Freak mother Jane is only in three episodes, but her actress was nominated for an Emmy for her colorful second appearance.
- Nikolai, the Chummy Commies visitor to town who nearly fights a duel with Maurice in "War and Peace", is a beloved and iconic character even though that's his only episode.
- City Mouse beautician Cyndy, Shelly's old best friend and the Second Love of Shelly's first husband, only makes one visit to Cicely (plus being mentioned a couple of other times) but makes a strong impression in that episode.
- The sweet malamute who Maggie thinks is a reincarnated ex-boyfriend in "Animals R Us" is better-liked than many human guest stars.
- Joel's more sleek, confident, and hard-edged twin brother Jules is a big scene stealer even though he only appears in one episode, and an All But The Dream one at that.
- "Get Real" has four unusually memorable guest stars: Enrico Belotti the Flying Man (who makes one equally well-received reappearance), Steve and Adrienne Gould (nuclear scientists turned circus proprietors), and the Goulds' precocious but crafty daughter Nina.
- Solvang, the recently-widowed mountain woman who Joanna Cassidy plays in "The Three Amigos," is remembered and praised long after her screentime is finished.
- Maggie's one-shot boyfriend Arthur, who is implied to be a shapeshifting bear, only makes one appearance. Still, the unique Magical Realism of that episode and his deeply emotional and spiritual attitude make him one of the most memorable guest stars of the show for many viewers.
- Roslyn and Cicely, the town's founders, only appear in one flashback episode (and get mentioned a few other times) but are hugely popular for being a cute, unfettered lesbian couple who turned a frontier cesspool into a utopian community for a period.
- Two guest stars from "Nothing's Perfect" have near-iconic status for some fans.
- Amy, the brilliant, animal-loving, passionate mathematician, is probably Chris's best-liked Girl of the Week, and almost everyone wishes she had appeared more.
- Bunny-Ears Lawyer clock expert Rolf is quite popular due to his temporary Those Two Guys dynamic with Ed and how he delightfully vexes and humbles Maurice.
- Stern Old Judge Elizabeth Percy from "Crime and Punishment" has a lot of fans for her Reasonable Authority Figure decisions and Beneath the Mask moments that come out during her Odd Friendship with Ruth-Anne.
- Viktor, the Former Regime Personnel KGB agent now making a living selling old dossiers and other communist memorabilia, makes a lasting impression beyond his appearance in "Do the Right Thing."
- Joel's parents only appear in one episode, in early season 5, but are praised for the amount of Hidden Depths and Character Development they display in that episode.
- Violin-obsessed mental patient Cal Ingraham only makes four appearances, but is one of the best-liked characters to debut in the final two seasons.
- Chris's on-off girlfriend, April, is only in two episodes (being notable enough to be brought back a year after her first appearance) but is viewed as one of his more entertaining and colorful love interests throughout the show due to a couple of Ms. Fanservice moments and her ability to connect with him that manifests through engagement in his art projects in her first appearance and I Want My Beloved to Be Happy moments in her second one. It can be surprising to see that her actress only had one other role outside of the show.
- Turk, Frog, and Tiny, the three Badass Bikers Ruth-Anne befriends in "Fish Story," are quite popular for the way they zigzag All Bikers are Hells Angels by viewing the biker lifestyle as serious business while also being laidback family men with 9-to-5 jobs and making some Deconstruction comments and analyses about the biker lifestyle.
- Bruce Baum is only onscreen for about one minute as a gregarious border patrol officer who came to Canada as a draft dodger, but he's still one of the better guest stars of season 5.
- Father Kevin McKerry from "A Wing and A Prayer" makes a powerful impression as a Badass Preacher who takes the town's backwoods zaniness and lack of organized religion in stride.
- Maurice's Good with Numbers Country Mouse distant cousin (also named Maurice), whom he unsuccessfully tries to groom as his heir in "Full Upright Position," might be one of the best-remembered season 6 guest stars. Another is Angelo Maxwell, the new town barber from "The Letter," who has a decent following for being in Witness Protection, having some Awesome by Analysis moments and being played by Bill Cobbs.
