These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Ensemble Darkhorse: Van Gogh. After the first episode he only ever appeared in cameos, but it's not hard to find fanart of him.
Fridge Horror: Why would the secret board of shadowy directors clone Hitler?
Hey, the guy was an extremely charismatic leader, which seems to be something the board would want to harness...
With how the other clones turned out, he was likely a tireless worker for world peace and equality.
Fridge Logic: To make a clone of someone, you need their DNA. There's a clone of Jesus. Where did they find Jesus's DNA?
Fridge Brilliance: They didn't have Jesus' DNA. Note that whatever your beliefs on Jesus' racial background, it's highly unlikely that He was of Latino American descent as depicted in Clone High. Venturing into Wild Mass Guessing territory, the likeliest explanation is that he was cloned from the suspect DNA of the Shroud of Turin.
Another plausible theory is that he's actually Ambiguously Brown, with his accent simply deriving from having a Latin foster family.
Maybe they found a genuine nail, thorny crown, or bit of cross?
In the third episode, A.D.D.: The Last 'D' is for Disorder, it's revealed Joan of Arc wears a retainer. Wouldn't that mean the original Joan of Arc had a deformed upper jaw? What makes it worse is that she says 'If this causes an overbite, [Gandhi], you're so dead.'
Research has shown that the real Cleopatra was anywhere between simply above average to ugly in appearance but most likely not incredibly beautiful, but since Cleo is rich she may have got plastic surgery.
Hollywood Homely: Joan, however some characters do seem to realize she's attractive before her reveal of Beautiful All Along. Heavily inverted with Marie Curie, who is hideous yet no one treats her any differently.
More specifically, Indians dislike the portrayal of Mahatma Gandhi in this show as a shallow, petty individual who easily caves to peer pressure and shallow whims. However, it's wholly justified due to Clone!Gandhi caving under the pressure to be the perfect paragon that the original Gandhi was. This is the main theme of the show.
Ho Yay: Well, JFK's foster-parents are a gay couple, plus there's JFK's crush on "John Dark". And his best friend forever Ponce in episode 10, complete with break-up and incessant weeping and crawling into the coffin. And then Abe holds him on the Thinking Dock.
Most Ho Yay of all, Gandhi's kiss with Abe in the episode "A.D.D.: The Last 'D' is for Disorder". Played for Laughs, but Gandhi still payed him for it, implying he liked it. Or he's stupid.