Silverlight: I believe I just did. (decapitates the Shadowbolt)
I'm a Marvel... And I'm a DC gives everyone a turn or two to monologue about something, but whenever the villains lecture someone, a rebuttal isn't far behind. Respectively, Superman responds to Lex Luthor's monologue with one clear-cut statement, and Spider-Man draws on his own experiences to show that Joker doesn't have a leg to stand on. However, it's ultimately Green Goblin who utterly destroys him verbally.
The scene in question comes later, but the way Gobby brushes off his standard death threat also warrants mention.
The Joker: Tell me something, my friend — ever dance with the devil by the pale moonlight?
Early on, when Rainbow Dash first runs into Trixie in Seaddle, Trixie tries to say they're Not So Different by pointing out that they're both braggarts. Rainbow shoots her down by pointing out that at least she knows to stop before someone gets hurt, and then when Trixie tries to challenge her to prove who's superior, Rainbow just walks away, saying she's not worth it. Trixie has a brief Villainous Breakdown at this.
Later, this exchange during her final fight with General Zod:
Rainbow Dash: (blocks blow) "I’ll only kneel to two ponies. And you’re not one of them!" (throws Zod through a wall)
In the second arc, there's her refusal to submit to Brainiac's Sadistic Choice and let him break her, instead saving Scootaloo and rushing off to stop the bomb in Cloudsdale.
"Welcome to Equestria, Brainiac."
The Princess of Themyscira: During the Final Battle, Ares derides the mortal realm, and questions why Diana is even bothering to protect it. Diana responds with a speech about all the good and beauty she's seen since coming to Equestria, despite the mortal ponies' flaws, saying that is exactly why she won't stop defending them as long as she's still breathing.
My Little Avengers: During the Final Battle, each of the Avengers does this to their Dark Avenger counterpart — Captain Equestria breaks through the Ghost Flyer's attempted Mind Rape via sheer willpower and delivers a brief "World of Cardboard" Speech before beating the Flyer unconscious; Firebird and Iron Pony both point out the hypocrisy of Iron Monger and Red Skull's own Breaking Lectures (with Iron Pony giving his own WOC speech in the process); and when Loki (in the middle of a Villainous Breakdown) is screaming at Thor for defying him, Thor retorts that after everything Loki's done, he has no right to be upset about Thor fighting back.
Neferet: While we are permitted to excel in the Arts and live freely this part of our daily lives, we are not always permitted to worship our Goddess Nyx with such freedom, while humans are – and for much of human history have always been – able to worship their god or gods. While we have not judged them for their decisions, for we are Nyx's children and the humans are not hers, they feel it is their liberty to judge us for ours. As you have no doubt heard or seen, this has culminated, as of late, in the slaughter in cold blood of our beloved professors by religious zealots. We have done nothing to them, and yet they feel the need to do something to us-
Light: Excuse me, Neferet, but you cannot possibly believe that.
Neferet: Oh, what can I not possibly believe? Am I to believe that two honoured professors were not murdered on our grounds? That this wasn't most likely the fault of the People of Faith?
Light: On the contrary, what you cannot possibly believe is that the vampyres were completely faultless on their part.
Light: You see, Neferet, my father was a police detective. Thanks to this, and international broadcasts, I know that vampyres have committed many atrocities against humans.
Neferet: I see, and how do you know that these 'atrocities' are not stories cooked up by the media, or stories force fed to you by humans themselves?
Light: I know because I have seen the case files myself, and memorised every detail, down to the date, the place, and the number of human victims in each case. Since the end of the 1970s, the list goes as follows:
1979, on the 28th of October, in Prague, a 12 year old girl was found two hours after she was killed. 1982, on the 5th of November, in London, a 1 month old child was orphaned before dawn. 1983, the 12th of December, Paris, a 17 year old was drained of her blood and thrown into the River Seine.
1984, the 29th of February, Moscow, a single mother was eviscerated, and her 5 year old son along with her. 1985, the 12th of April, Berlin, 13 year old twin girls were found dead in their home, from exsanguination. 1986, the 2nd of May, Vancouver, Canada, a man in his mid-thirties was mutilated and drained of his blood.
1987, the 31st of July, in Washington DC, a whole family of four was found dead on Pennsylvania Avenue, North-West. 1988, the 7th of September, Beijing, an 11 year old boy was found dead outside his school's gates. 1989, the 11th of November, Seoul, a 5 year old girl's parents were decapitated and drained of their blood and found dead in their home.
Neferet: Light, that's enough-
Light: 1990, the 25th of December, Kuala Lumpur, a teenage boy went missing, only to be found drained of his blood in the city centre park. 1991, the 13th of January, Sapporo, a 20 year old woman was disembowelled and drained. 1992, the 28th of February, Tokyo, a young family were found in their home, slaughtered, their throats ripped out save for their 3 year old son, who lived. All of them were killed by vampyres, and not one vampyres has been identified as of-
In "The Evil Gods Part 1", in response to Annabeth deriding Christianity as "old and tired", Jerry says "But at least our way works! Amen" before killing her.
When the Prayer Warriors confront Josef Stalin near the end of "Threat of Satanic Commonism," he says that he was "just trying to help" by allowing freedom of religion. They then respond with "They only person you were trying to help were yourself! You evil Satanic Kant!" before killing him.
At one point during Queen Of All Oni, Ikazuki gives a captive Tohru a "The Reason You Suck" Speech about how weak humans are, only for Tohru to point out that it was humans who defeated the Oni in the first place, and that even now, they need human bodies to do anything. Ikazuki doesn't take that well.
When the blindfold Jade starts wearing following her encounter with Lung allows her to shrug off an onion to the face, she gloats about it, only for Viper to throw a cut up piece of onion into her mouth, shutting her up by leaving her sick for a bit.
When faced with Shizune, a fundamentalist Christian who kills everyone who disagrees with her, Yukariko denounces Shizune as "nothing more than a murderer who perverts Jesus Christ's teachings of compassion, tolerance and love!" Shizune is unfazed, and says Yukariko is a false Christian as a Catholic.
During the Final Battle, The Usurper makes a last-ditch attempt to get the Himes to help him make a perfect new world, only to get rejected yet again.
Mai: "To hell with your new world that is only perfect for you! We'll decide our own future!"
Earth and Sky: When the Flim-Flam brothers are in Cloudsdale, Professor Destiny starts giving a rant about how their flight harness makes them superior to the pegasi... only for an angry mob to start pelting them with pies.
Terra: What could possibly be more important to you ponies than survival?
This is immediately followed by Terra stating that she's still more powerful than all of them and trying to finish them, only to be stopped by the previously-neutralized Elements of Harmony reigniting.
Terra: I have more power than all of you combined. Against me you have nothing. No weapons. No magic.
(Attempts to kill Twilight, but the Elements reignite, blocking and then immobilizing her)
Twilight does this to Loneliness on multiple occasions throughout the final battle with her. Finally, Trixie finally manages one when she defies Loneliness in the end before grabbing her Element Of Harmony and destroying her.
Fluttercruel to Princess Luna, when Luna brings up the possibility that they really can't know who the "original" and who the "copy" is. 'Cruel replies by saying that they're both real and it doesn't matter whose the "original". Luna is impressed by this.
Sweetie Belle gets one on Silver Spoon's mother in "Butterflies" — when she says the CMC don't deserve to be Silver Spoon's friends, she points out how well connected they are through their sisters (and Rainbow Dash in Scootaloo's case), and is completely polite while doing so.
Later on in Dark World, Rarity has one against Fluttercruel after the latter tries to pull a Not So Different on her when she declares she's going to kill Fluttercruel for torturing Fluttershy's mind for centuries until Cadence's spirit saved her.
She gives Fluttercruel another one when they each summon small armies to aid them. Fluttercruel uses disposable Mooks. Rarity asks for help from the souls of Fluttercruel's victims and gives them stone bodies to use, and points out how they're different.
The Passenger gets two more in Dark World 26. First, when she tries to get Twilight to kill the seapony Aquamarine (who is acting on Discord's orders to take feathers from the petrified Celestia and Luna as part of a means to maintain Sky Ocean after Discord's defeat), Twilight refuses, stating that she won't harm the seaponies, who are innocent of any wrongdoings, despite what the Passenger thinks. Then a little later, Shady's spirit shows up and comforts Discord while the Passenger is mocking him, saying that while Discord has done many terrible things, the self-righteous Passenger is worse.
Twilight and company get quite a few against the Nameless Passenger after she reveals herself as Twilight's potential future selfNightmare Eclipse/Paradox as she tries to convince Twilight to become her, shooting down all her arguments.
Spike delivered what may be the most awesome Shut Up, Hannibal! in the series, when he refused to restrain Twilight for her.
Nightmare Eclipse: YOU'RE THE ONE WHO'S LOST HER MIND Twilight! Everything in this world is nothing but shadows of a lie of a fantasy. You're not being rational! Spike! Restrain her!
Nightmare Eclipse: Spike, I'm warning you!
Spike: I'll have you know I am NOT a robot, or a distortion, or any of those other things. And I need to be loyal to the real Twilight.
Bright Eyes gets one against Cruel Eyes/D___t's Shadow of Existence, using her love of Lancer to help her beat hisBreaking Lecture.
Bright Eyes: "...We can't be certain...if what we think of ourselves is true, and we can be certain what others think of us is true. The heart is always subjective. All we have left in the end is who we chose to trust. I'd trust Lancer with my life, I trusted him with my heart a long time ago!"
Cruel Eyes: This is not over, I swear to you, I shall stalk your soul and its iterations across creation, and when your heart cries out in deepest despair, I will be there to devour you, we will meet-!
Bright Eyes: (impales him through the heart) Sorry, but that's not happening. (bisects his head with enough force to drive her sword into his chest, destroying him completely) Ever.
In Shining Armor 18, Minuette gets one against the Master when he tries to tempt her into opening her fob watch and becoming him again. After she resists his attempts, he snaps and yells that she has no choice because she is him. Her reply?
In "Character Rerailment", Silver gets a few against her now Nightmarified friend Diamond Tiara while she's trying to convince her she only exists to be her bully toady and is worthless otherwise.
Diamond Tiara: What have you ever done, Silver on your own? Who has ever liked you when you weren't of any use to them at all? Who would miss you if you died? I know I wouldn't. Your parents? They'd just have another foal to replace you. Fillies like you are a dime a dozen. You're a worthless, pointless, little waste of space."
Silver Spoon: ...I...I'm not worthless…I'm not worthless! The Crusaders took me in! They didn't need to! I wasn't of use to them at all back then! I was their BULLY! That was the only Silver Spoon they'd ever known! And they STILL helped me...they still SAVED me...My Cutie Mark...I don't know what it means, but it's not 'being born with a silver spoon in my mouth' or being a minion...the heart in the handle is more important. Just because I don't remember the charity doesn't mean it didn't matter to me!
In the Chaos Verse (an official spinoff of the Pony POV Series above), that universe's version of Discord offers one to the Dark World version of himself from the main series (or rather, an illusion of him created by Nightmare Phobia; same difference). When Dark World!Discord tries to tempt Chaos Verse!Discord back to evil, Chaos Verse!Discord not only rejects him, but thanks him for showing him the error of his ways, and stating that by extension, it was him who saved Fluttercruel from Oblivion. This causes the illusion to fall apart and allows Discord to break free.
A Fathers Wrath: During a fight against Hidan, Orochimaru is put under a jutsu where his son Naruto appears before him and tells him he hates him and he resents the fact he is the son of a man who did so many horrible experiments to others. Orochimaru is ready to succumb to his words as memories of his past and horrible deeds he did showup until another memory appears and he responds with this line which breaks the Jutsu.
Orochimaru My son loves me and that means you're not my son!
A rare case of a villain doing this to another villain happens at the end of Shadowchasers Torment where the surviving villains are hauled away. PaniK gives the typical Evil Gloating, but most of the others are just as sick of him as the heroes are: