Hokuto/Shirase and her Bloody Hokuto form are now voiced by Yuka Igarashi, rather than Yuri Amano. With the later reveal that "Hokuto" is actually the modern-day Nanase, with Sanane essentially being her Body Double, one could say Megumi Ogata's role was likewise Darrin'd.
Due to the death of Kaneto Shiozawa in 2000, Kairi is now voiced by Yoshitaka Kure.
Naoki Sagawa provides the voice of Garuda instead of Osamu Hosoi.
Hosoi's other role in the EX series (and Fighting Layer), Allen Snider, has been recast to Daisuke Yokota.
Like Allen, Blair's previous VA in EX1 and Fighting Layer, Hikari Tachibana, has been replaced in favor of Rui Tanabe.