- James McAvoy has said in numerous interviews that Charles' suits were ripped off from the iconic outfits worn by Detective James "Sonny" Crockett from Miami Vice, a popular TV series which made its debut in 1984, one year after the events of this film. Don Johnson's wardrobe on the show ignited a fashion trend, so in the movie-verse, it appears that Xavier was ahead of his time style-wise. Michael Fassbender mentions that Erik has a suit which was inspired by Detective Ricardo "Rico" Stubbs, Crockett's partner.
- Nightcrawler owns a jacket which is a replica of Michael Jackson's from the famous Thriller music video, which is somewhat recursive because it resembles his costume from the comics.
- When Quicksilver is talking to his mother, his T-shirt has a cartoon print of The Six Million Dollar Man, and he plays Pac-Man. He also switches the TV's channels from the news to Knight Rider. He later changes into a Rush T-shirt, and during the denouement of the film, he's seen in an Atari one. While rescuing Xavier's students, Peter takes a moment to perform the Moonwalk Dance.
- The Star Trek: The Original Series episode "Who Mourns for Adonais?" plays on Ororo's TV set.
- While in class, Jubilee wears a Journey T-shirt.
- While sending the students back to bed during Jean's nightmare, Charles chides them "Spit spot."
- Return of the Jedi is shown to be playing at the movie theater during the mall sequence.
- Like Professor X, Leto Atreides II in Children of Dune (who is also portrayed by James McAvoy) is captured, placed on a slab against his will, is too weak to fight against his captor, and endures a mental assault which almost causes him to lose his identity.
- Singer confirmed that the scene when Angel gets his wings back from Apocalypse was inspired by the transformation scene in An American Werewolf in London.
- In the Opening Monologue, the quote "Give someone wings, and they may fly too close to the sun" refers to the Greek myth of Icarus and Daedalus.
- Xavier is a benevolent, wise and beautiful leader with brilliant blue irises, mind-reading and telepathic communication abilities who temporarily gets Drunk on the Dark Side with Black Eyes of Evil when exposed to evil power, just like the Elf matriarch Galadriel in The Lord of the Rings: The Fellowship of the Ring.
- The character poster for Apocalypse◊ evokes the Yorick's skull scene from Hamlet.
- Singer shot a scene which was directly influenced by a seminal moment from Apocalypse Now.We're watching a bald man loom out of the shadows in a stone room, somewhere in a violent foreign land. Emotion wracks his face, and a solitary tear trickles down his cheek. We brace ourselves to hear the iconic line "The horror, the horror" before remembering we're not actually on the set of Apocalypse Now, but X-Men: Apocalypse. We're not seeing Marlon Brando shoot a key scene as Colonel Kurtz, but James McAvoy's Professor X. His head's shaved for accuracy, not madness.
- "You're going to need a bigger house." Looks like Jaws was on TV somewhere when Apocalypse assimilated the world's culture.
- In the deleted mall scene, Scott compares Jean with Boy George.
- Apocalypse's message was to "every man, woman and mutant".
Shout Out / X-Men: Apocalypse