At the beginning of Secret Wars (2015), with the Ultimate Universe crashing into Earth-616 and both realities seconds away from ceasing to exist, Frank casually strolls◊ into a bad guy bar and just gun down Wilson Fisk, Norman Osborn, and Bullseye, among others.
During the Daredevil arc "The Devil, Inside and Out," fellow vigilante and occasional ally Matt Murdock AKA Daredevil is slowly breaking down while imprisoned at Ryker's Island. Frank is sitting a diner reading about Murdock's almost Punisher-like activities in jail. Deciding that Murdock needs a reminder of who he is, Frank gets up, heads outside, and casually breaks the neck of a pimp beating on one of his prostitutes, advises the girl to get clean and out of the life, and surrenders to a nearby police officer. Just to go help Daredevil.
Later, during a prison riot intended to kill Daredevil, Frank calmly waits reading a book in his unlocked cell for DD to come get him...though any thug that dares take a run at him ends up in a pile of bodies outside the cell. He subsequently uses the riot to break himself and Daredevil out...by pretending to hold "helpless" blind lawyer Matt Murdock hostage at gun point, simultaneously springing them and creating a little more doubt that Murdock is Daredevil (which he's on trial for).
Frank jumping out of a plane without a parachute from 35,000 feet up.
That's nothing. Frank has jumped from a nuclear missile, with a rescued child.
His rematch against the resurrected Russian, who's been transformed into this bizarre cyborg mismash (he even grew breasts because of the hormone treatment needed for the resurrection to work), but is even stronger because of it. Frank wins because Spider-Man tries to intervene, only to get knocked unconscious. Frank uses him as a human shield, knowing that his powers makes him strong enough to survive, and manages to throw the Russian off the building.
Their third fight, where Frank finally kills the Russian by tying him to a nuclear bomb. The Russian is fine with dying that way.
Later in the same series, Frank goes undercover at an Auction of Evil. When, after allowing himself to be captured, he escapes and kills the overly-confident thug who was trying to beat some information out of him...
Dying Thug: ...who...who are you?
Frank: Die curious.
One issue where Frank meets Ghost Rider includes, at one point, Frank resisting the Penance Stare. And when the Ghost Rider, a demon from Hell, asks how...
Frank: I regret nothing.
That time Frank took down Electro!
The 2018 run has Frank taking on A- List supervillians and whose his first victim? The Mandarin himself.
The second crossover with Batman, when Frank has The Joker cornered in an alley, and the clown just assumes he's going to get hauled back to Arkham as usual... only to find out The Punisher is not that kind of vigilante.
Frank: *aims his gun* I got all the cure you need right here, comedian!