Lex Luthor is Superman's sworn archenemy. If the alien Superman embodies selflessness, Earth's own son Luthor is selfishness personified. He uses his genius-level intellect and driving ambition only to advance himself and crush others. Even without superpowers, Lex is easily the most dangerous human being on the planet.
Head of the technological powerhouse LexCorp, Lex is devoted to ridding the world of Superman for the good of humanity - or rather, for one man: himself. His talk of empowering the common man is only a cover. Charming, fascinating, and utterly indifferent to the suffering of others, Lex is a true sociopath.
—DC Universe Online character bio
I have all the characteristics of a human being: blood, flesh, skin, hair; but not a single, clear, identifiable emotion, except for greed and disgust.
—Patrick Bateman, American Psycho
Alex Mercer: This... source. It's the key to genetics — but it's also a machine, churning out the worst viruses ever seen. Things that — if they got out of the lab — could literally erase human civilization as we know it.
Joseph Schulze: And how did that make you feel?
Alex Mercer: I wasn't paid to feel.
The man with the cold voice had killed a woman. He was talking about it without any kind of remorse - with amusement.
He knew he should feel bad for the dork, but he only felt annoyed. He felt worse about the fact that he didn’t feel bad than he did about what he’d just read.
Strausser: "I'm a sergeant now."
Miles: "Well, let's be honest, you're a sociopath, is what you are. Before the blackout, you'd have been locked in a rubber room."
John: “I've been clinically diagnosed with sociopathy. Do you know what that means?"
Rob: "It means you're a freak."
John: "It means that you're about as important to me as a cardboard box. You're just a thing - a piece of garbage that no one's thrown away yet."
"People are simply things to be used. Used and thrown away."
— Matt Engarde, Phoenix Wright: Ace Attorney: Justice For All
"Juri... That power... That eye... She's no ordinary fighter. She is an untamed animal who seeks to destroy and consume all that enters her sight...She has altered her own body in her insatiable quest for power. She respects no law. No morality. She does whatever it takes to achieve her goals and quench her limitless thirst."
Professor Zoom: “Enjoy your petty little victories, Flash. But no matter how fast you run, you can't save everyone... not the ones that matter to you."note
Superman: "Best to keep your mouth shut. If you don't want bugs in your teeth." (Flies away with Zoom in tow.)
Batman: (To Flash) "Thawne's a classic sociopath. They have a knack for knowing just what'll get under your skin."
Flash: "I know."
The concept of empathy is understood by [DeFalco], but... irrelevant.
—Farid, Call of Duty: Black Ops 2
Abandon your captured family. Give up on the friend who betrayed you. Feel no guilt for the murder of your friend. If you could find the will to be ruthless, then you'd be freed from all your stress in an instant.
—Ryoma Sengoku, Kamen Rider Gaim
What if my problem wasn't that I don't understand people, but that I don't like them? What if I was the kind of person who was obliged to hurt you for this? I mean physically. I think you'd have to believe afterward, if you could, that agreeing to participate and then backing out at the critical moment was a mistake. Because that's what I'm telling you, as clearly as I can.
—Louis "Lou" Bloom, Nightcrawler
Roose has no feelings, you see. Those leeches that he loves so well sucked all the passions out of him years ago. He does not love, he does not hate, he does not grieve. This is a game to him, mildly diverting. Some men hunt, some hawk, some tumble dice. Roose plays with men. You and me, these Freys, Lord Manderly, his plump new wife, even his bastard, we are but his playthings.
— Barbrey Dustin, A Song of Ice and Fire
She is a psychopath. While mine's more of a mild case, Mona is, well, take my psychopathic tendencies Up to Eleven.
— Leon Da Autism describing his girlfriend Mona,The Autistic World of the Autist
I fucking hate the world.
A mortal driven insane by Malkav loses the capacity to empathize with other people. The person cannot even recognize that other beings are people. Malkav's Chosen become creatures as amoral as any vampire lost to the Beast, but retaining a human intellect in every other way. These "isolates" treat other people as potentially threatening animals, as competitors for food, or as food themselves. They do not shrink from murder and cannibalism; torture fascinates these human-looking creatures, as they ponder the conundrum of an object that mimics the appearance of pain.
—Vampire: The Masquerade - Gehenna