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Dr. Meredith Grey (Portrayed by Ellen Pompeo)
Meredith Grey is the Narrator for the series, giving a voice-over dialogue for every episode (with very few exceptions). Daughter of a world-famous surgeon, she has been dogged by allegations of nepotism—especially after she also found out that she was sleeping with her boss, also-world-class neurosurgeon Derek Shepherd. The show follows her adventures as she attempts to navigate the world of internship (and eventually residency) at Seattle-Grace Hospital. As the star of a medical drama, Meredith deals with a lot of crap.
- Abusive Parents:
- Ellis Grey was extremely negligent and incredibly harsh to Meredith. As Alzheimer's sets in, we get scenes of her yelling about how little she respects her daughter.
- Her father, Thatcher, flat-out abandoned them both in Meredith's childhood and again in adulthood.
- Aloof Big Sister: Is this to Lexie at first, but thaws the ice as the two grow closer.
- Broken Bird: Whooo boy! One has to wonder if Shonda Rimes has an enemy out there named Meredith Grey for all of the crappy things that happen to Meredith starting from before the show even starts, never mind what comes after.
- Character Development: In the fourth season, she starts talking therapy and begins to actually acknowledge and address her problems.
- Cool Big Sis: Eventually evolves into this for Lexie.
- Disappeared Dad: Her dad abandoned Meredith and her mother when she was a child.
- Drowning My Sorrows: Meredith and tequila.
- The Eeyore: To the point she used to call herself "dark and twisted". Eventually with Character Development (and a little help from therapy) she grows out of it a good deal.
- Happily Married: To Derek. Initially anyway.
- Heterosexual Life-Partners: With Cristina. So much that Meredith mentioned that she was the third wheel of her mariage, which is incidentally falling apart now that she left. She even wonders if she is the love of her life, but makes it clear she is not attracted to her at all in a sexual way.
- In-Series Nickname: Following her plane crash, she became a frightening attending, described as a monster of mythic proportions, awarding her the nickname of Medusa.
- Looking for Love in All the Wrong Places: Before settling down with Derek.
- Love Triangle: With Derek and a variety of other men, such as Finn. Also with Derek and Addison.
- Missing Mom: Loses her biological mother in 3x17, though this allows her to bond with her father's new wife Susan. Then she dies six episodes later.
- Morality Pet:
- For Richard, who sees her as a daughter due to her being the child of the woman he loved as well as having seen her growing up from afar.
- Also for Alex. Though they were at odds with each other at first, Meredith eventually became one of the few people Alex would open up and talk to aside from Izzie (who was his Love Interest and who he had a Slap-Slap-Kiss relationship for the most part anyway). Indeed when he tells on Meredith on season eight, Cristina calls him on it by saying that he has just hurt the one person who ever cared about him.
- Really Gets Around: Before her relationship with Derek stabilized, she was in the habit of getting drunk and picking up random men for one night stands.
- 10-Minute Retirement: Along with the other plane crash survivors to protest the sale to Pegasus.
- Trauma Conga Line: She's the star of a Medical Drama. What do you expect?
- "Well Done, Daughter" Gal: Toward her mother. Her father too, to a lesser extent.
- You All Meet in a Bar: How she met Derek.
Dr. Alex Karev (Portrayed by Justin Chambers)
A late addition to the pilot (Chambers had to be stitched in during re-shoots), Alex personifies Troubled, but Cute and benefits from the All Girls Want Bad Boys trope. When not sleeping his way through the interns, he's also a pediatrics specialist, suggesting that his Man Child tendencies are good for something.
- A Day in the Limelight: Narrated a Season 9 episode instead of Meredith.
- Disappeared Dad: druggy, alcoholic, abusive. Played by James Remar.
- Freudian Excuse: Had a shitty childhood, with an abusive father, causing him to be put in foster care in his teens. Then he dates a patient who later goes crazy. Just when things start to be looking up for him after getting together with Izzie, she gets cancer, leading to their marriage. Then Izzie gets fired, she leaves him, then gets shot and almost dies in an elevator giving him PTSD. Then his brother has a mental break due to his schizophrenia, trying to kill his sister, causing him to be put in a mental institution. Now he has survivor's guilt after the plane crash, which he was supposed to be on. No wonder he sleeps with interns.
- Love Triangle: Between Izzie and Lexie, but then Izzie left him and Lexie died. He's currently dating Jo.
- Promotion to Parent: Took care of his younger brother and sister because of their parents' mental problems/drug addictions.
- Really Gets Around: Tends to sleep with interns a lot.
- Relationship Upgrade: In Season 11, Alex discovers he is now Meredith's "person" due to Christina's departure. He attempts to help Meredith with Margaret Pierce claiming to be her half-sister.
Dr. Miranda Bailey (Portrayed by Chandra Wilson)
Originally nicknamed "the Nazi" for her no-nonsense attitude, Bailey was gradually revealed to be Not So Above It All. One of the few characters that every other character likes. Has a son, Tuck, by her husband Tucker.
- Black and Nerdy: If we're to believe the descriptions of her as a teenager: she was part of the school band, was smart enough to tutor other students and has some knowledge of science fiction which she retains to this day.
- Brutal Honesty:
- To the point people expect her to lay "The Reason You Suck" Speech lectures every time they do something wrong.
- When Burke asks her in episode two what she really thinks of his character, Bailey says she isn't supposed to, since he is her superior. He tells her she can be completely honest for the next 30 seconds. She proceeds to totally tear him down, and when he tries to interrupt, she says she still has a few seconds left.
- Deadpan Snarker: Nearly from her first appearance."I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change."
- Heroic B.S.O.D.: After she accidentally gives several patients a staph infection, leading to their deaths. It's discovered that the gloves mandated by the Corrupt Corporate Executives at Pegasus Holdings were defective, but Bailey still takes it hard. Very hard.
- In-Series Nickname: In fact, she earned two nicknames.
- She was once called "The Nazi", because she was the most severe doctor at the hospital. She didn't mind being called that, since she likes names that inspire terror. However, after her surgery on a racial supremacist (who had the Nazi swastika tattooed on his torso), she made it pretty clear that no one was allowed to call her that anymore.
- Beginning season 9, she has a new nickname, radically different from her ancient one: B.C.B, which stands for Booty Call Bailey. She is not amused when she discovers it.
- Mama Bear: Toward her son, Tuck, along with her former interns.
- Married to the Job: Almost literally, after her divorce from her husband.
- Not So Above It All: In earlier seasons she was usually portrayed as the Only Sane Man in a hospital full of relationship drama. Eventually Bailey got enough storylines that show that she can be just as quirky as any of the other characters.
- One of Us:
- In-universe: After a teenager gets himself encased in concrete, she bucks him up by referencing Han Solo's adventures in carbonite.
- In season 9 when she and Webber are accompanying the survivors of the plane crash on their flight back to Seattle she tells Dr. Webber she keeps thinking they're going to crash on a tropical island and be attacked by a polar bear.
- Parental Favoritism: Played with. The interns are not actually her children, but she refers to them as such several times in later seasons, claiming to have raised them, and in season nine she admits to Grey she had a favorite among them: George O'Malley.
- Platonic Life Partners: Miranda will drop everything to help Richard (including operating in emergency on Adele, Richard's wife, on her wedding day), and Richard is very protective of her. Their relation is so strong that Adele actually wondered if Richard didn't cheat on her with Miranda. Also, in season 9, Miranda takes it very hard when she believes Richard turned his back on her, something which pushed her even deeper into her massive Heroic B.S.O.D..
- Runaway Bride: Was engaged to marry Ben. Didn't at first, because Adele came into the hospital, but eventually did.
- Sassy Black Woman: Has her moments.
- Second Love: With Dr. Ben Warren.
- Team Mom: To the interns, who she several times refers to as her "babies" or "children" (no, not always in a good way) and to an extent to the whole known hospital staff. If they have a problem or need some advice, they usually go to her, even knowing they might get lectured.
Dr. Richard Webber (Portrayed by James Pickens Jr.)
The Chief of Surgery at Seattle Grace, Dr. Webber is just as no-nonsense, and just as secretly-a-Team Dad, as Bailey is. A well-respected surgeon who has spent most of his career in Seattle, he also carried on a long-term affair with Meredith's mother Ellis, while his own wife Adele looked the other way. He is also the closest thing to a father figure Meredith has.
- The Alcoholic: Recovering but fell off the wagon in season six, he gets better.
- Da Chief: Stepped down in season six after falling off the wagon, and in season eight to take the fall for Meredith after she tampers with Derek's clinical trial.
- Badass Teacher: God help you if you ever threaten his hospital and his students.
- Cool Teacher: Was one to Miranda during her internship, and the two of them developed a strong relationship based on mutual respect and actual friendship.
- Henpecked Husband: There's very few people he's more straight up obedient towards than Adele.
- Love Triangle: Between Adele and Ellis. Notable for being part of his Backstory and for having gone on for a very long time.
- Married to the Job: So much that it was one of the reasons he neglected his wife.
- Morality Pet: Meredith. As Derek notes, Richard is the picture of professionalism in all things regarding the hospital, except for when something concerns Meredith Grey.
- Not So Above It All: Despite being the Team Dad as well as Da Chief, and being one of the characters who most gives the "life lectures" Grey's is so well-known for, Richard has several moments of this.
Richard (to Alex, after catching him in the act of pulling pranks): You need to step up your game.
- He has quite the competitive side, and has entered several silly skill disputes, such as with Cristina in an early season.
- There is one instance where he helps Alex to pull off pranks on a male nurse who Alex really dislikes. He became quite more relaxed ever since he forwent his job as Chief of Surgery.
- Parental Substitute:
- To Meredith. Having an affair with her mother and contributing to her broken childhood by means of Bystander Syndrome is a source of deep guilt to him, and he has a strong fatherly and protective instinct towards her. It takes Meredith a while to fully accept it.
- To Jackson in later seasons, after marrying his mother Catherine. Interestingly, both Meredith and Jackson have desconstructed Richard's role as this in different occasions by reminding him that he is not their father, and Richard admitted as much, but reconstructed as their relationships still stand as this anyway.
- Platonic Life Partners: Miranda will drop everything to help Richard (including operating in emergency on Adele, Richard's wife, on her wedding day), and Richard is very protective of her. Their relation is so strong that Adele actually wondered if Richard didn't cheat on her with Miranda. Also, in season 9, Miranda takes it very hard when she believes Richard turned his back on her, something which pushed her even deeper in her massive Heroic B.S.O.D..
Dr. Arizona Robbins (Portrayed by Jessica Capshaw)
An attending physician in pediatrics, Arizona was raised in a military family and was named after a battleship. She is The Spock to Callie's McCoy, despite being typically more upbeat and childlike in comparison, and the two have formed a stable marriage together.
- An Arm and a Leg: The plane crash results with her having her left leg amputated above the knee.
- Cigarette of Anxiety: Arizona smokes when she is nervous, a habit that she hates.
- Comfort Food: When her brother died, she ate a lot of donuts to feel better.
- Disabled Snarker: During recovery after the plane crash, Arizona snarks at Callie out of resentment that she allowed Arizona's leg amputation.
- Exiled to the Couch: She sleeps on the couch until Callie is ready to forgive her for cheating with Lauren.
- Fatal Flaw: Spends an episode trying to figure out hers, due to Mark saying she should know what it is before trying to get Callie back after leaving her to go to Africa and then coming back. At the end of the episode he tells her that her flaw is that she bails when things get hard, which makes her unreliable.
- Genki Girl: Especially during work, where she has to play the part to sick children. Though she's quite energetic out of the hospital too.
- Happily Married: To Callie until they separated.
- Has Two Mommies: She has a daughter, Sofia, with Callie.
- Heroic B.S.O.D.: Following her amputation, she just lies on her bed, doesn't seem to leave her apartment, which she still shares with Callie, and doesn't take care of her daughter. She harbors a lot of resentment towards Callie too, and not even the death of Mark seems to move her.
- Lipstick Lesbian: Arizona is rather feminine in appearance and personality, and she is attracted to women.
- Military Brat: Her father is a colonel, and her brother died in war. She was even named after a battle ship.
- Promotion to Opening Titles: In season six.
- Really Gets Around : Before getting married to Callie, slept with a lot of nurses of the hospital and after her break-up with Callie, with the help of wingman Richard Webber.
- The Mentor: To Alex, when he starts to specialize in pediatrics. When Callie suffers a car accident and has a high-risk operation with Arizona watching from the gallery, Alex leaves said surgery to go to Arizona's side.
- 10-Minute Retirement: Along with the other plane crash survivors to protest the sale to Pegasus.
- Token Minority: Not for Grey's itself, which actually has a more racially diverse cast that Real Life Seattle, but for the television industry as a whole: when Robbins was Promoted to Opening Titles, she became the only lesbian starring character on primetime television.
- She's now a Twofer Token Minority because she is a lesbian and physically disabled.
- Your Cheating Heart: On Callie with Dr. Lauren Boswell at the end of Season 9. The marriage ain't so stable now.
Dr. Owen Hunt (Portrayed by Kevin McKidd)
A former Combat Medic who toured in Iraq, Hunt serves as Seattle Grace's foremost trauma surgeon. He has an aggressive, sometimes-unorthodox training style and a lot of confidence, which endeared him to Cristina. However, he wants children and she doesn't, which has proved to be a source of friction in the past.
- The Atoner: For the plane crash, with a dose of trying to avert the Bystander Syndrome, after discovering that he signed off on changing the charter company contract without bothering to check the new company's safety records.
- Beware the Nice Ones: Cristina and Owen did not talk about the abortion ever since it happened, leading to suppressed emotions and Owen breaks in mid Season 8.
- Da Chief: Starting in the third episode of season eight.
- Declaration of Protection: Owen tells the shooter that if he touches Cristina, he will kill him. There are also other events where Owen saves and protects Cristina from harm.
- Happily Married: Zigzagged Trope. He and Cristina get married, but it only works out so well because he wants Babies Ever After and she doesn't.
- Amicably Divorced: Then they go for this, and are arguably closer as exes than as spouses.
- The McCoy: To Cristina's Spock.
- Promotion to Opening Titles: In season five, episode six.
- Sole Survivor: After his first appearance, he returned to Iraq, where his entire unit was slain.
- Shell-Shocked Veteran: Suffered from PTSD upon his return. This was his major arc throughout season five.
- Star-Crossed Lovers: Cristina and Owen love each other but have faced countless obstacles in their relationship and break up every season (But eventually they get back together. This remains to be seen in Season 10)
- 10-Minute Retirement: In Season Nine, in protest of the other characters' ten-minute retirements. His is even shorter than theirs, lasting less than an episode.
- Trigger: Wakes up strangling Cristina. His therapist later informs him it was likely because of her ceiling fan - the blades symbolic of the propellers on a helicopter.
- Your Cheating Heart: Sleeps with a patient's friend while angry with Cristina over her abortion.
Dr. Jackson Avery (Portrayed by Jesse Williams)
One of four new residents introduced in Season Six after Seattle Grace merges with the nearby Mercy-West hospital, Jackson was originally viewed by the main characters as interference and competition. Time and familiarity have made him more accepted, however, and he is currently a plastic-surgery fellow. Though his grandfather is the famous Harper Avery (of the Harper Avery Foundation, and the Harper Avery Award), and his mother the nearly-as-famous Catherine Avery, Jackson was never pushed much because he was "just the pretty one," and became a driven surgeon of his own accord.
- Brainless Beauty: Subverted. He is often mentioned to be very attractive by nearly everyone who meets him and the fact that beauty might be all he has is often brought up. His own family seemed to rule his out as this trope, and he had to work hard to show he was just as smart as anyone.
- Big Brother Instinct: To April, following her nearly losing her virginity to Alex, causing him to punch Alex in the face.
- The Charmer: Desconstructed. At point he tries to use his looks to get Teddy to let him do some surgical procedures, by batting eyelashes and flirting. She ends up confronting him by having Jackson answer a quick quiz about a heart surgery, to make sure he really isn't a Brainless Beauty after all.
- Disappeared Dad: Abandoned him after he couldn't handle the pressure of being an Avery. His mother Catherine (who presumably married into the family, since she still goes by Avery today) raised him single-handedly.
- Mr. Fanservice: See Walking Shirtless Scene.
- Promotion to Opening Titles: In season seven.
- Sex Equals Love: At first played straight. Subverted after April's pregnancy scare.
- Walking Shirtless Scene: Tends to take his shirt off frequently.
- What Beautiful Eyes!: People often comment on his green eyes, usually when talking about how handsome he is.
- Will They or Won't They?: with April.
- You Are in Command Now: The bankruptcy plot is resolved when the Harper Avery Foundation buys out the hospital, unexpectedly resulting in Jackson becoming chairman of the board.
Dr. April Kepner (Portrayed by Sarah Drew)
Another of the newly-introduced residents, April has gone on to be a trauma surgeon. She is principled, hard-working, neurotic and—quite surprisingly for the show—a 28-year-old virgin, by choice. Rhimes created the character as a Designated Monkey to be disliked and fired after two episodes, but changed her mind and kept her around; this might explain the audience's Love It or Hate It response to the character.
- Break the Cutie: To start, getting fired, tripping over the body of her best friend and getting covered in her blood during the season 6 finale. Then in season eight, she loses her virginity to Jackson, the guilt over breaking her promise to Jesus causes her to fail her boards, causing her to get fired by Owen and all of her offers rejected.
- Butt-Monkey: Among her peer residents, who mostly just considered her annoying or didn't take her seriously. They didn't even see her as a contender in the run for chief resident, and when she won the job, it took a long while for her to get their respect.
- Characterization Marches On:
- When she first arrives to Seattle Grace, much like the other residents from Mercy West she acted a tad rude to others and sometimes had a feel of Bitch in Sheep's Clothing going on. After she gets fired and returns, she is a lot better and plays more the part of The Ingenue and Genki Girl, though she slipped back into her old part a few times. Meredith even lampshaded at one point, and she apologized saying it was habit.
- In the episode which reveals April is still a virgin, she gives as main reason the fact that she waited too long, and men seem to find her annoying. She even gets close to sleeping with Alex of all people, thanks to a newfound crush. In later episodes however anything about her chastity is portrayed to be closely related to her Christianity and that she didn't have sex before because of a promise to Jesus, which makes those other episodes mentioned before quite the Early Installment Weirdness for that aspect of her character.
- Chaste Heroine - Used to be, until she lost her virginity to Jackson.
- Genki Girl: She's a ball of uptight energy.
- Good People Have Good Sex: Starts getting on with Jackson, repeatedly.
- Happily Married: To Jackson, at first. But now they're not even married anymore.
- Promotion to Opening Titles: In season seven.
- Odd Friendship: Uptight, conservative April with upbeat, confirmed-lesbian Arizona.
- Once a Season: Gets fired. Possibly a nod to her original purpose.
- Open Mouth, Insert Foot: She is rather prone to saying the wrong thing at the wrong time.
- Outliving One's Offspring: Her first child with Jackson is stricken with osteogenesis imperfecta, and dies in the womb.
- Second Love: Matthew, an EMT who is also waiting for marriage.
- Runaway Bride: Until a love confession from Jackson prompts her to leave her husband standing at the altar while she and Jackson run away in his car, and get married fifteen hours later.
- Took a Level in Badass: Kepner slowly but surely become more assertive as more time passes. Eventually, in season 11, she decides to join the army to treat people on the field. Nearly a year after, she is back, and by the conclusion of "Time Stops" there is no doubt that she is badass.
- Wacky Marriage Proposal: Matthew arranges a flashmob to the tune of The Proclaimers' "(I Would Walk) Five Hundred Miles", which Meredith declares true proof that he and April are perfect for each other. She accepts.
Dr. Maggie Pierce (Portrayed by Kelly McCreary)
Current Head of Cardiothoracic Surgery, she revealed to Richard Webber shortly after starting work that Ellis Grey is her birth mom.
- Annoying Younger Sibling: Sometimes to Meredith, especially when she wants to know about Meredith's love life.
- Genki Girl
- Happily Adopted: Was very happy in her adoptive family. She just wanted to know about her real parentage.
Dr. Amelia Shepherd (Portrayed by Caterina Scorsone)
Youngest sister of Derek Shepherd, and also a neurosurgeon. She took Derek's job as the Head of Neurosurgery.
- The Alcoholic: Got better.
- Always Second Best: Feels that way about her brother.
- Outliving One's Offspring: Her baby lived for 43 minutes.
Dr. Nathan Riggs (Portrayed by Martin Henderson)Cardiothoracic surgeon who worked with April Kepner during her time in Jordan. After bringing a patient to Grey Sloan Memorial Hospital, he got a job working there. Seems to have some Unfinished Business with Owen Hunt.
Dr. Jo Wilson (Portrayed by Camilla Luddington)
One of a new crop of interns introduced in Season 9 and Promoted to Opening Titles in Season 10, Jo seems to have it all together, with Alex mockingly calling her "Princess." But this is Grey's Anatomy, of course she has a Dark and Troubled Past.
- Dark and Troubled Past: Her former husband used to beat her and almost killed her. She changed her name so he couldn't find her.
- Double Standard: Abuse, Female on Male: Benefits from it at one point, with at least one Lampshade Hanging / deconstruction behind her back.
- Freudian Excuse: Jo suffers from PTSD after the physical abuse she suffered at the hands of her husband, when she attacked Jason Myers and put him in the hospital it was likely an adrenaline rush 'fight or flight' reaction she could not control. She said he 'grabbed her'.
- In Universe Nickname: Cristina calls her "Ponytail." Alex calls her "Princess."
- Like Brother and Sister: with Alex.
- Will They or Won't They?: ...until it isn't.
- Mysterious Past: Was formerly married to someone she's running from, who may be still trying to find her. And "Josephine Wilson" is not her real name.
- Parental Abandonment: Was abandoned by her mother when she was 6 weeks old, bounced around foster homes until she started living out of her car aged 16.
- Promoted to Opening Titles: In Season 10.
Dr. Stephanie Edwards (Portrayed by Jerrika Hinton)The emotional one of the group, she is primarily known at this point for being Jackson's rebound after breaking up with Kepner.
- Blind Without 'Em: subverted in Season 10 when she gets laser surgery.
- Hidden Depths: recently revealed to be a former cheerleader. This was her first Character Development on the show.
- Love Interest: to Jackson.
Dr. Ben Warren (Jason George)
An anesthesiologist from Mercy West, introduced in the 6th season during the merger arc. He quickly becomes romantically involved with Bailey, though this becomes complicated by his dreams of pursuing a further education and becoming a full-blown surgeon.
- Family Versus Career: A Rare Male Example. Chooses "family" by quitting his residency and resuming his old job at Seattle Grace Mercy West Grey Sloan. Even more interestingly, Miranda calls him on it, feeling very disappointed that he gave up surgery for her and her son.
- Long Distance Relationship: with Bailey, because his residency is elsewhere.
- Nice Guy: One of the few characters everybody likes. They also trust him enough to let him scrub in on nerve-wracking surgeries even when he's just in town to visit his wife.
- Put on a Bus: To the Spin-Off "Off The Map," where he provides the current page quote.
- Second Love: Bailey's.
- The Bus Came Back: After Off The Map was canceled.
Dr. Penelope "Penny" Blake (Samantha Sloyan)A surgical resident who transferred from Dillard Medical Center, prior to its closure, who treated Derek Shepherd after his car accident. She is dating Callie Torres.
Dr. Isaac Cross (Joe Adler)
Dr. Mitchell Spencer (Joe Dinicol)
Dr. Andrew DeLuca (Giacomo Gianniotti)
Dr. Ellis Grey (Kate Burton)
Meredith's mother, introduced in the pilot episode as the person Meredith is narrating the show to. This got dropped, but the fact that Mrs. Grey has early-onset Alzheimer's did not. This simply adds to Meredith's troubles, as one of Ellis's last (lucid) thoughts was that she wanted her condition kept secret. And, as of the pilot episode, she doesn't have a lot of lucid thoughts anymore.
- Abusive Parents: Was not precisely supportive to Meredith."I raised you to be an extraordinary human being. So imagine my disappointment when I wake up after five years and discover that you're no more than ordinary. What happened to you?"
- The Ace: A world-renowned surgeon. After she retires due to her illness, everyone assumes she's off working medical miracles somewhere.
- Driven to Suicide: After her first break-up with Richard, when Meredith was six. While Meredith watched. Not really driven to suicide as much as staging it to either get Webber back or make hm feel bad. That night she found out she was pregnant with second child (Webber's) so didn't stick around to enact the full plan. Meredith figured out the fake suicide attempt part during a therapy session (after ferryboat crash iirc)
- Early Installment Weirdness: in the pilot, she's the person Meredith is Narrating to.
- Love Triangle: Married Thatcher, but quickly met Richard Webber.
- No Social Skills: Has a habit of saying whatever crosses her mind. Then she got Alzheimer's and lost that filter and things got worse.
- Opposites Attract: With the warm Team Dad we call Chief Webber.
- Unwitting Instigator of Doom: At the end of "The Time Warp" she and Webber have a drink at Joe's in memory of their deceased patient, when she sees Webber has a club soda she tells him it's not an appropriate drink to toast an Irishman with and orders him a vodka. It's not explicitly said but it seems from his reaction that Webber may have known he had a problem and been sober at that time.
- What You Are in the Dark: Because of her disease, we find out.
Thatcher Grey (Jeff Perry) and Susan Grey (Mare Winningham)Meredith's spineless father and his new wife. Though Thatcher is typically too intimidated to bond with Meredith, Susan did her best for both of them, alternately pleasing and confounding her stepdaughter with attachment-style parenting. They have two daughters, Lexie (see above) and Molly (Mandy Siegfried).
- The Alcoholic: Thatcher.
- Dirty Coward: Thatcher.
- My Beloved Smother: Susan. Meredith grew to appreciate it eventually.
- Never My Fault: Thatcher.
- Parents as People: Thatcher particularly.
- Your Cheating Heart: Thatcher knew that Ellis was carrying on with Richard, which is part of why he left.
Dr. Catherine Avery (Debbie Allen)Jackson's famous mother. She becomes an alternative love interest to Webber, especially after Adele begins to completely forget who he is.
- Happily Married: To Richard.
- Mama Bear: Is very protective of Jackson, and her grandchild, as April Kepner very nearly finds out the hard way when Catherine has to be talked down from having Jackson sue her for custody.
- My Beloved Smother: Has shades of this.
Adele Webber (Loretta Devine)Webber's long-suffering wife. Richard believed that he was able to keep his affair with Ellis secret from her, but discovered in the second season how wrong he was. He stayed with her out of honor, though. Like Richard's other great love, she too develops Alzheimer's, and eventually needs to be committed to an assisted-living facility. She earned the show its other Emmy as a Guest Actress.
- Undying Loyalty: To her husband. He shows it back, though in different ways.
Sofia Robbin Sloan Torres
Former Main Characters
Dr. Derek Shepherd (Portrayed by Patrick Dempsey)
Our first sight of Meredith Grey, in the pilot episode, was of her waking up naked on the couch, realizing she was late for her first day as an intern at Seattle Grace, and shooing her one-night-stand partner out the door. Our first sight of Derek Shepherd, new Seattle Grace hire and God Of Neurosurgery, was when Meredith was assigned to his service and recognized him as her one-night-stand partner. Despite Meredith's concerns over sleeping with her boss, the two entered into a functional relationship... Only to have it disrupted by the arrival of Derek's estranged-but-still-legally-wed ex. And then the second season started and things got really complicated.
- And Starring: Credited as "And Patrick Dempsey"
- Beard of Sorrow: Grows one in season five during his Heroic B.S.O.D. arc.
- Career-Ending Injury: Damages his hand in the plane crash, causing him to only get 80% function back and his hand going numb during a surgery. Eventually fixed.
- Catch-Phrase: "It's a beautiful day to save lives."
- Da Chief: Briefly in season six, resigns following the shooting.
- Happily Married: To Meredith, despite their issues.
- In-Series Nickname: McDreamy.
- Killed Off for Real: In season 11 episode 21, from a head injury.
- Knight in Sour Armor: ...Or, in the alternate universe, McDreary.
- Mr. Fanservice: Had a couple scenes where he was shirtless, and even one scene when he is supposedly completely naked because he and Meredith were making out in the living room and were caught during the act. With time passing, he no longer provided this service, leaving this job to Mark Sloan and Avery.
- Love Triangle: With Meredith on one corner and either Addison or Nurse Rose on the other.
- 10-Minute Retirement: Along with the other plane crash survivors to protest the sale to Pegasus.
Dr. Cristina Yang (Portrayed by Sandra Oh)
Meredith's BFF—or "person," in the show's parlance—Cristina (no H) is an Insufferable Genius whom Meredith nonetheless takes to. Bluntly sarcastic, Married to the Job and unashamedly ambitious, she has chosen to specialize in heart surgery, and is known to jump at the opportunity to do cutting-edge, impressive operations. Sandra Oh won a Best Supporting Actress Golden Globe for the role after the show's first season.
- Cool Teacher: Not only has one in the person of Mr. Feeny, but (much to the audience's surprise) becomes one as an attending surgeon supervising the latest crop of interns.
- Deadpan Snarker: Her most defining trait, along with her being an exceptional surgeon, which naturally leads to her being an Insufferable Genius.
- Defrosting the Ice Queen: We're still in the defrosting process, but she's gotten much, much better. Lampshaded by Bailey in season 9 when she notices Cristina starts to show that she cares about her interns and even gave Bailey relationship advice.
- Designated Victim: While there's plenty of trauma to go around the whole cast, it seems like most season have a story arc that causes Cristina to become a sobbing wreck.
- Disappeared Dad: Her biological father was killed in a car crash when Cristina was 9. She tried to hold his chest back together with her hands. It didn't work.
- Genius Slob: Her personal hygiene is fine as you'd expect of a surgeon but in episode 10 of season 2 we see her apartment is close to Trash of the Titans level of messiness as opposed to Burke's place which she claims would be clean enough to perform surgery in.. She even tells Burke that she hired a maid once, but she ran away.
- Good Girls Avoid Abortion: Averted when she gets one in the eighth season premiere, leading to tension with Owen.
- Happily Married: To Owen. For a while, at least.
- Heroic B.S.O.D.: In season seven following the shooting in the season six finale. Again after the events of season 8.
- Heterosexual Life-Partners: With Meredith, sometimes to the point of overshadowing her actual marriage.
- Hot for Student: Shacked up with her cardio professor while at Stanford.
- Insufferable Genius: And how!
- I Want My Beloved to Be Happy: Cristina let Owen go in the Season 9 finale so that he can have a family of his own as Cristina did not want to be a mother.
- Karma Houdini: An odd example. Though plenty of horrible stuff happens to Cristina on a more or less regular basis, it's all mostly random. Whenever she does something wrong, however, especially in regards to believing she's above the rules whenever she disagrees with them, she is never punished, only rewarded, which leads to absolutely no character development in regards to her arrogance.
- Star-Crossed Lovers: Cristina and Owen love each other but have faced countless obstacles in their relationship and break up every season (But eventually they get back together. This remains to be seen in Season 10)
- 10-Minute Retirement: Along with the other plane crash survivors to protest the sale to Pegasus.
Dr. Izzie Stevens (Portrayed by Katherine Heigl)
The Establishing Character Moment for Isobel Stevens came in the fourth episode of the show, after Alex discovered that she modeled lingerie under the stage name "Bethany Whisper" and pasted her pin-ups all over the hospital. Izzie stripped down to her underwear and castigated the other characters for their sexism, pointing out that her modeling career has allowed her to escape the bank-breaking student loans they all have to live with. She then embarked on an ill-fated relationship with heart-transplant patient Denny Duquette, in the process earning the show one of its two acting Emmys. However, Heigl wanted to focus on her family and burgeoning film career, and asked to be written out.
- Author Avatar: According to Shonda Rhimes, who should know.
- Bridezilla: An unusual version in that she's not even the bride: Meredith passed to Izzie all planning for her wedding as a way to cheer her up and keep her busy during chemo. (Conveniently, the Why Waste a Wedding? trope pops in later.)
- Hospital Hottie: She was even a model, which is why she had no student debt like the others.
- I Have This Friend...: She gives her interns information about "Patient X" as a way of both teaching them and figuring out what's wrong with her. Also, unusually for this trope, none of the interns ever make the connection that she is Patient X.
- Ill Girl: ...Though they do figure out that she has skin cancer.
- I See Dead People: Hallucinates Denny throughout the fifth season, which seems to be evidence that she's simply gone mad. Actually, the cancer has reached her brain.
- Never Live It Down: Invoked. After she cuts the wire on Denny's LVAD, other characters rib her about it endlessly. Having said that, in a real hospital this would have resulted in legal action and possibly jail time, not just a (voluntary) resignation followed by probation, so if anything she's a Karma Houdini by way of the Rule of Drama.
- Put on a Bus: Following being fired she divorces Alex and leaves.
- Commuting on a Bus: Returned a few times before leaving for good in the twelfth episode of season six. Heigl has since mentioned that she would be open to doing a few more appearances to wrap up loose ends, but Rhimes says it's unlikely, as bringing her back in would disrupt her long-term plans for the show.
- Screw the Rules, I'm Doing What's Right!
- Shaming the Mob:"And what are these? Oh my God, breasts. How does anybody practice medicine hauling these things around?"
- So Beautiful, It's a Curse: Justified. The few patients who recognized her from centerfolds all went on to question her credentials as a trained doctor. Because, after all, a woman can't be both beautiful and smart. (Well, okay, the Double Standard itself is not justified, but the fact that people would employ it...)
- Teen Pregnancy: Revealed in an early episode. Later, she gave her daughter a needed bone marrow transplant.
Dr. George O'Malley (Portrayed by T.R. Knight)
One of the original five interns, George was the token nice guy, nursing a very visible crush on Meredith. He then moved on to Callie but ended up caught between her and and Izzie, failed his intern exams, and struck up a friendship with Lexie after being, essentially, held back a year. Eventually he decided to join the Army as a trauma surgeon and save lives. Which he did.
- All Love Is Unrequited: a long-standing thing for Meredith.
- Butt-Monkey: Definitely. Spends most of the first season as hapless comic relief. Ends it by getting over his crush on Meredith and going on a date with a cute nurse. ...And coming down with syphillis.Izzie: *walking in on George bent over a gurney with his pants down* "What are we doing?"
Meredith: *poised at his backside with penicillin syringe* "Curing George's syph."
George: "Breaking George's spirit."
- A Day in the Limelight: The first character to provide voice-over narration besides Meredith. Since then, a number of others have gotten to as well.
- Extreme Doormat: Has his moments.
- Fourth Date Marriage: Had one with Callie, essentially.
- He Cleans Up Nicely: YMMV, but, on any given day George can come off looking kind of sweaty and pudgy and unkempt. But seeing him showered and in a suit, especially his army uniform, WHOA.
- Hope Spot: Has saved a girl by literally throwing himself in front of a bus, has joined the Army to save lives, and the girl is now enamored of her Knight in Shining Armor. ...In the finale of Season 5, where he dies.
- Love Triangle: Between his best friend Izzie and his actual wife Callie.
- Out of Focus: In the fifth season, he doesn't do much. This is part of why they wrote him out: they ran out of ideas for what to do with him.
- Your Cheating Heart: On Callie with Izzie.
Dr. Preston Burke (Portrayed by Isaiah Washington)The head of cardiothoracic surgery, Burke was ambitious and sometimes arrogant, with his eye set on succeeding Richard as the Chief of Surgery. He and Cristina started a quirky, intense relationship that would have led to marriage if he hadn't done that "leave your bride at the altar" thing.
- And Starring: Credited as With Isaiah Washington
- Career-Ending Injury: Is shot at the end of the second season, resulting in tremors in his right hand. Cristina goes to great lengths to cover it up.
- Drill Sergeant Nasty: Not literally, but Dr. Burke's "pick on one guy" intern training method is based on a technique employed by actual DIs. Yes, this makes George Private Pyle.
- Insufferable Genius: Not as much as Cristina, but still had his moments.
- Real Life Writes the Plot: Isaiah Washington was summarily fired at the end of Season Three for homophobic slurs against T. R. Knight. Thus Burke leaves Cristina at the altar and sends his mother to collect his things.
Dr. Addison Montgomery Shepherd (Portrayed by Kate Walsh)
Addison knows how to make an entrance: her first line was also the last line of Season 1, and a Wham Line: "Hi, I'm Addison Shepherd. And you must be the woman who's been screwing my husband." The story of How She Got Here is gradually explained over the next few years: she and Derek married right out of med school, and she eventually cheated on him with his best friend. Derek walked away without even bothering to file for divorce, and she carried on with the best friend until realizing she still loved her husband and wanted him back. An opening in OB/GYN at Seattle Grace was the perfect opportunity. The Triang Relations continued for some time, and while Meredith won Derek, Addison got a consolation prize: her own Spin-Off, Private Practice, which was set in Los Angeles and ran for six seasons before wrapping up in 2013.
- Anti-Villain: Type IV as she's not a bad person, just a rival to Meredith.
- Ascended Extra: Was only set to appear in five episodes in season two. Ended up with her own Spin-Off.
- Last Episode, New Character: Though she still got first billing in the guest-star list, despite appearing onscreen for all of 20 seconds.
- Odd Friendship: Poised, composed Addison with down-to-earth, irreverent Callie. Also provides a Meta Twist: unusually for this show, which per Word of God is about "smart women competing with each other," their friendship does not have Drama Bombs dropped on it every other episode.
- Put on a Bus: To Private Practice, at the end of Season Three. This has not precluded the occasional Commuting on a Bus, both to and from Seattle.
- Your Cheating Heart: While Derek was quite obviously hurt about it, he eventually admitted that his own emotional distance from Addie did not help things.
Dr. Mark Sloan (Portrayed by Eric Dane)
The "McSteamy" to Derek's McDreamy, the two have been close for a very long time; he even served as best man at Derek's wedding to Addison. ...And then was the "best friend" she cheated on Derek with. His presence as a Guest Star in the second season caused quite some strain (Derek punched him), but after he joined Seattle Grace's permanent staff they were able to patch up. This on-and-off-again pattern kind of set the tone for all his other relationships: with Callie, his Platonic Life Partner with whom he had a daughter, Sofia; and with Lexie, his most long-standing romantic entanglement. Mark was written out during the first two episodes of Season Nine, possibly at Dane's behest and possibly because Executive Meddling reduced the show's budget.
- Always Someone Better: Derek was this to him his whole life, which may have contributed to him sleeping with Addison. Still he considered Derek his best friend above all and came to terms with his jealousy, even joking about his Always Second Best status from time to time.
- Anguished Declaration of Love: To Lexie, when she's dying.
- Anyone Can Die: In the Season 9 opener after spending 30 days in a coma, Derek and Callie pull his plug as he requested in his Living Will.
- Anything That Moves: To the point that the nurses actually unionized against his love-em-and-leave-em attitude.Bailey (to said nurses): I would like to offer my thoughts on Dr. Sloan. This man is a whore. Has always been a whore and probably always will be a whore. But I mean that's not a secret. He's not keeping it hidden. (...) He's nasty.
- No-Sell: The one time he tries it on Cristina.
- Ascended Extra: Was only set to appear once in season two, until fans asked Shonda Rhimes for him to come back, which lead to his Promotion to Opening Titles in season three, episode three.
- Deadpan Snarker: Has his moments.Mark (to Derek who is in the elevator with Meredith, Addison, and Rose): I bet you're wishing that you're taking the stairs right about now.
- Heterosexual Life-Partners: With Derek.
- It's All About Me: Prior to his Character Development.
- In-Series Nickname: In his first appearance, he is given the nickname McSteamy.
- Ladykiller in Love: With Lexie and/or Julia. According to him, it's just Lexie, and it always has been.
- Mr. Fanservice: Shows up at the end of the second episode of season three in Addison's hotel room, barely wearing a towel.
- Platonic Life Partners: With Callie, despite the fact that they have had sex quite a few times, which eventually gave us Sofia.
- Really Gets Around: He probably slept with nearly all the nurses in the hospital. From the main cast, he has been with Lexie, Addison, Callie, Teddy and Reed.
Dr. Alexandra "Lexie" Grey (Portrayed by Chyler Leigh)
Meredith's half-sister was produced after their mutual father, Thatcher, re-married without telling Ellis. She and Meredith initially had a frosty relationship, due in no small part to Meredith's Parental Abandonment issues, but the two eventually became quite close. Sweet, emotional and featuring a photographic memory, Lexie became something of a Tagalong Kid for the five interns, forming a relationship with Jackson and a crush on George. Her most enduring romantic entanglement, though, was with Mark Sloan. Chyler Leigh, who is kind of Crazy Awesome in real life, eventually decided to move on to other projects, but not before helping to contribute to the Season Eight finale, one of the whammiest Wham Episodes of the series.
- Adorkable: Lexie is innocent, endearingly awkward, and timid, with a tendency to ramble on when she's nervous.
- All Love Is Unrequited: To George.
- Badass Adorable: She is incredibly sweet and adorable, and she is one of the smartest, most promising surgical residents at Seattle Grace due in part to her photographic memory. As Derek puts it: "She has a photographic memory, we're all out of our league."
- Break the Cutie: Boy, howdy! For as many horrible things that happen to Lexie, you gotta wonder if Shonda hates her as much as she hates Meredith!
- The Cutie: She is upbeat, rather naive, very caring, and serves as the Tagalong Kid to the interns.
- Dropped a Bridge on Him: Gets crushed by plane debris at the end of Season 8.
- Early-Bird Cameo: Appears in the last two episodes of Season 3, before her formal introduction in the Season 4 premiere.
- Extreme Doormat: Goes out of her way to befriend Meredith in Season 4, including eating an omelet made by Meredith. This puts on a new spin on "Lethal Chef" because Lexie, who knows she is allergic to eggs, ate the thing anyway.Lexie: I'm an adult child of an alcoholic. That is what happened to me. I have boundary issues. When Meredith made me eggs this morning, I couldn't not eat them. I had to pretend I wasn't allergic to eggs and now I have a rash covering my entire body.
- Foreshadowing: Lexie's younger sister, Molly, appears in Season 2, mentioning her older sister who is in med school at Harvard. Considering that Lexie herself didn't appear for another two seasons, this was either Shonda Rhimes planning out her Myth Arc or planting a Schrödinger's Gun.
- As mentioned, Meredith doesn't know her father remarried. Cristina drops the Wham Line on her: "Did you meet your sister?" Molly herself doesn't learn of the relation until her return appearance.
- Grade Skipper: She skipped the third grade.
- In-Series Nickname:
- Little Grey, used usually by residents or attendants, to distinct her from her older sister.
- Lexipedia, due to her excellent Photographic Memory.
- Kill the Cutie: Dies at the end of season 8 due to a plane crash.
- Nice Girl: Lexie is a very caring, friendly, and kind girl.
- Photographic Memory: She has such a prodigious ability that she remembers everything, even minor details. This allowed her to ace her residency exam. She got pretty famous among her colleagues thanks to it, and they frequently refer to her as "Lexipedia."
- Self-Induced Allergic Reaction: In the season 4 episode "Lay Your Hands On Me," when Meredith cooks an omelet for her, due to Lexie's Extreme Doormat tendencies towards Meredith and her delight at Meredith doing something nice for her, she eats the omelet even though she is allergic to eggs. She ends up getting a full-body rash.
- Sorry to Interrupt: Lexie has an unfortunate knack for walking in on people in the middle of making out or having sex, which results in poor Lexie making the most mortified expressions. For instance, once, she walked in on Callie and Arizona having shower sex.
- Tagalong Kid: Even though she's not actually a kid, she's the youngest of the main cast and is Meredith's little sister, so she tends to be treated like this trope by everyone else.
- Unrequited Love Switcheroo: Starts off with a thing for George, but he's too focused on his own problems.
- Youthful Freckles: Lexie has freckles, which reflect her youth and naivete.
Dr. Erica Hahn (Portrayed by Brooke Smith)
Burke's former rival, and replacement head of Cardiothoracic Surgery, Hahn was a workaholic who ran Cristina ragged, partially because Cristina reminded her of herself. She became romantically involved with Callie before being unceremoniously written out in the middle of Season Five. Members of the press, and Brooke Smith herself, have alleged Executive Meddling and an attempt to "de-gay" the show, though creator and showrunner Shonda Rhimes claims it was the natural end of Hahn's character arc.
- Ascended Extra: Had a few appearances in seasons two and three before becoming a regular in the fifth episode of season four.
- Chekhov's Gunman: Not only Hahn herself, but also her patient—he was supposed to get the heart Izzie stole for Denny.
- Defrosting Ice Queen: Throughout season four she was a massive bitch toward Cristina, banning her from her OR. After Richard telling her that she needed to be a better teacher and starting a relationship with Callie, she became more likeable.
- Dr. Jerk: She's rather abrasive to just about everyone, patients included.
- Put on a Bus: She leaves the show after getting into a fight with Callie.
- The Rival: To Preston Burke.
- Screw This, I'm Out of Here!: We see her heading to her car after breaking up with Callie.
- This Is Unforgivable!: Her reaction when she learns of Izzie's LVAD antics: she criticizes Webber's administration and demands Izzie be fired. Webber shoots her down, and when Callie defends the hospital and Izzie (in that order) as well, Erica gives up.
- What Happened to the Mouse?: No suggestion is given that we'll never see her again. Cristina has to deliver an Info Dump about it next episode.
Dr. Teddy Altman (Portrayed by Kim Raver)Theodora Altman is a friend of Owen's, having served as a trauma surgeon alongside him in the Army. Hired as a new head of cardiothoracic surgery and a mentor for Cristina, she initially saw Yang as a rival due to her own unrequited feelings for Owen. Later she got involved with Henry Burton, an ill man with a rare disorder, and married him so that he could take advantage of her health insurance. This was really the only thing she did on the show, which might explain why Kim Raver did not accept a contract renewal when the option was offered her.
- Action Girl: Prior to her first appearance, she was in the Army along with Owen.
- Citizenship Marriage: To Henry, in order to get him a good medical care. Turned alright since they grew to
- Put on a Bus: After Raver decided to leave the show. She is fired by Owen in the Season Eight finale so she can take an awesome new post at Army Medical Command.
Dr. Heather Brooks (Portrayed by Tina Majorino)Heather Brooks was one of the five new surgical interns introduced in season 9.
- Killed Off for Real: In the first episode of season 10.
Dr. Shane Ross (Portrayed by Gaius Charles)
The only male amongst the new five newbies, Shane is dead set on getting into the neurosurgery program. Shepherd isn't so sanguine.
- Ambition Is Evil: Evidently being set up for this in Season 10.
- False Friend: Sometimes tries to backstab Heather Brooks, Shepherd's actual choice as his protégé, in order to supplant her.
- Gone Horribly Right: His actions lead to Brooks' death, when he substitutes her as the person assigned to find Dr. Webber, himself Only Mostly Dead by electrocution. Brooks herself wasn't so lucky.
- Heroic B.S.O.D.: Once Brooks dies.
- In Universe Nickname: Cristina calls him "Happy," as part of her Theme Naming of "interns after Seven Dwarfs" thing. (As Jo's nickname indicates, she wasn't able to keep up the sequence.)
- The Pollyanna: Eternally upbeat, at least in Season 9.
Dr. Leah Murphy (Portrayed by Tessa Ferrer)
The sarcastic one of the group. She's careful about who she lets her guard down with.
- Ambiguously Gay: Sleeps with Alex, and then with Arizona... and then never expresses romantic or sexual attraction to anyone after that. It's terribly unclear whether she was bisexual to start with, or if she just decided that If It's Arizona It's Okay.
- If It's You, It's Okay: With Arizona.
Dr. Calliope "Callie" Torres (Portrayed by Sara Ramirez)
One of the first new characters to be added to the cast, Dr. Torres first appears in the second season as a Love Interest to George, who at the time had just had a chance to consummate his crush on Meredith—she was having a weak moment, with the end result that it Went Horribly Wrong. Needless to say, Callie looks appealing by contrast. An orthopedics specialist, Callie lives in the basement of Seattle Grace to save on rent and get a jump on awesome overnight surgeries. She frequently acts as a conscience to the other characters.
- Bi the Way: Callie is attracted to and has had relationships with both men and women.
- Brainy Brunette: While it's a given since she's a doctor, Callie is also noted to be very applied in studies. Her study cards for the interns' exams are considered legendary, and she also has a infallible "Torres Method" for studying, which Dr. Webber directly asks her to share with Meredith in order to help the latter in the resident's exams.
- Cartwright Curse: Nearly every major character she's had sex with has had something terrible happen to them. George and Mark both died, and Arizona nearly lost her life in the same incident that led to the latter's death, but still ended up losing her leg in the process. In retrospect, Erica was probably smart enough to get out while she still could.
- The Cast Showoff: In the musical episode. Sara Ramirez was in the original cast of Spamalot, for which she won a Tony Award.
- Cure Your Gays: Callie's father brings her childhood priest to the hospital to convince her that faith can cure her sexuality. She is righteously furious.Callie: You can't pray away the gay!
- Embarrassing Middle Name: Iphigenia.
- Full-Name Basis: Well full first name, Arizona is the only regular character to call her Calliope instead of Callie at least to begin with, though eventually she does start using Callie too with Calliope only being used occasionally.
- Happily Married: To Arizona, until they divorced.
- Has Two Mommies: She has a daughter, Sofia, with Arizona.
- Odd Friendship: Callie seems to have a penchant for these.
- With Owen, in recent seasons — which makes sense, when you consider that they were married in the Alternate Universe episode.
- With Meredith, after Cristina is gone. Callie was never exactly on particularly bad or great terms with her, but they’re more or less confidants now.
- With Bailey, which started more or less during Season Five and stayed through.
- She also has a camaraderie with Cristina, whose personality is nothing like hers, that rises from them being roommates for a few seasons. Indeed when Cristina went through her Heroic B.S.O.D. in Season 7 at the same time that Callie was heartbroken by Arizona's depart to Africa, they spent almost an entire episode just hanging around together.
- Parental Abandonment: When she comes out of the closet, her father disowns her.
- Platonic Life Partners: With Mark, despite the fact that they have had sex quite a few times, but never had any romantic feelings for each other other than lust. This eventually gave us Sofia.
- Promotion to Opening Titles: In season three.
Denny Duquette (Jeffrey Dean Morgan)A major character in the second season, Dennison Duquette had congestive heart failure and spent several years waiting for a transplant. After he arrived at Seattle Grace, he and Izzie fell in love, leading her to (essentially) short-circuit the mechanical bits of his failing heart to bump him to the top of the transplant list. It worked, but then he died anyway, which was a very upbeat and happy way to end the second season.
- Organ Theft: Was essentially the beneficiary of it, thanks to Izzie. This becomes a plot point later when Michael Norris, the person who was supposed to get that heart, shows up at Seattle Grace.
- Unexpected Inheritance: To Izzie, in the form of $8.7 million.
"Jane Doe" / "Ava" / Rebecca Pope (Portrayed by Elizabeth Reaser)A character introduced in the third season, she was a victim of the same ferry-boat crash that almost killed Meredith. Pregnant and amnesiac, she was brought back to the hospital for repairs and facial reconstruction surgery, during which time she and Alex became involved.
- Domestic Abuser: The father of her child, which is why she fled. Makes it a little less understandable why she eventually went back to him instead of staying with Alex.
- Driven to Suicide: Fortunately, Alex is on hand.
- Heroic B.S.O.D.: After her pregnancy is revealed to be hysterical.
- Psycho Ex-Girlfriend: In name only, as she's an ex who turns out to be psycho (Borderline Personality Disorder)
- Quest for Identity: She is offered three different options for the face repair. To help her choose, Alex names them Maggie, Elizabeth and Ava.
- The Bus Came Back: Returns in Season 4.
Joe The Bartender (Steven W. Bailey)The bartender of the bar nearest the hospital, which serves as one of the major nexii of the show (along with the operating rooms and on-call rooms).
- The Bartender: His job.
- Has Two Daddies: Not Joe himself, but his two children, whom he adopted with his partner Walter in the third season.
- You Look Familiar: Steven W. Bailey appeared in the pilot as an anesthesiologist who was clearly not Joe.