In the second episode chain of custody rules over a case of attempted rape which was foiled by the victim biting her attacker's penis off leads to the immortal line:
Meredith What am I supposed to do with a penis?
In episode 9 of the first season George contracts Syphilis and undergoes a Humiliation Conga resulting in Meredith giving him a Penicillin injection in his butt with Cristina and Izzy watching to their very great amusement. The best part was when the infection was traced, resulting in George attacking Alex screaming:
In season 3 episode 2 Christina meets Burkes parents, while she's straddling him in her underwear.
This troper found Dr. Kepner losing it during a trauma certification drill sequence in Season 7 to be utterly hilarious. You just can't not laugh at a soaking wet woman hurling a dummy in the back of an ambulance and driving off about 100 metres down the road only to throw it out again.
Anyone want to argue with my extra special vagina vote?
In season 7, during Cristina's BSOD arc, she temporarily begins working as a bartender, to hilarious results. Seriously, one of the FUNNIEST episodes this troper has ever seen.
Everyone thinking that the middle east patient is Bono, due him being with guards. From the same episode, Lexie shooting ping-pong balls at everyone, including one of the middle-east patient's guard's.
What was particularly funny about it is that about five seconds earlier, Lexie had confiscated the ping-pong ball gun away from Alex for doing the exact same thing.
In the Backdoor Pilot for Private Practice, Addison's lampshading of the status of elevators in Grey's Anatomy— first the long monologue about how nice it is to be somewhere where the elevators aren't aphrodisiacs (to a man she's never met), followed by her conversations with the "Elevator Gods". It's made much more hilarious because it is *such* a lampshade.