The game takes place in an unspecified point in the future on a planet known as Red Earth, the second world to be colonized by humanity. On Red Earth, Dr. Faryan (called Dr. Gordon in the Japanese version) ventures into a cave and awakens an ancient evil that turns him into an evil being. Using his newfound abilities, Faryan creates mutated beast-men to serve as his minions, and imprisons nearly everyone on Earth. The only hope for humanity is a man (called Ken in the Japanese version but unnamed in the English version) who, with the help of his spirit guide, can transform into a werewolf.
Werewolf: The Last Troper
- Awesome McCoolname: In the Japanese version, the titular lycanthrope is given the name Warwolf.
- Big Bad: Dr. Faryan, the man responsible for unleashing the ancient evil and imprisoning the majority of the human race with his bio-engineered monsters.
- Magical Native American: The werewolf's spirit guide serves a similar role, though he appears to be East Asian rather than Native American.
- Our Werewolves Are Different: Unlike traditional werewolves, this one can transform whenever necessary, provided he finds the Sign of the Werewolf first. He can also transform further into a being with blades instead of hands.
- Punny Name: "Warwolf" would be identical to "Werewolf" if written in katakana, which is why the game's Japanese title uses romaji.
- Sequel Hook: At the conclusion of the ending credits, the words "next time" appear on screen, implying that Faryan will one day return to threaten humanity.
- Transformation Sequence: The opening cutscene depicts the protagonist's transformation into a wolf-man via closeups of his snarling face and a shot of him roaring triumphantly, accompanied by Dramatic Thunder.
- Transformation Trinket: The Sign of the Werewolf, which appears on-screen as a red letter "W", makes the hero transform into a werewolf, granting him longer-range melee attacks and wall-climbing abilities. A blue "W" turns him back into a human.
- We All Live in America: In the English version, the finale has the hero posing with an American flag. By contrast, the Japanese version simply shows him walking away into the night.