- Actor Allusion: Gaga Pee Pap is a mountain dancer, like VA Jesco White.
- Adored by the Network: Adult Swim really goes out of its way to promote the show to no end, notable in its bumps, going as far a criticizing people for not watching it.
- Author Existence Failure: Scott Hilley, who voiced Reverend Teardrop, died on September 8, 2015.
- Cross-Dressing Voices: Granny is voiced by the male Dana Snyder.
- Official Fan-Submitted Content: Sort of. Tammi was based on a character created by a fan who later befriended the show's lead animation. Despite loving the character and trying to get her on the show, some behind-the-scenes politics at Turner wouldn't let him, so they compromised by creating a vaguely similar character.
- The Other Darrin: Charles Napier was the voice of the Sheriff in the first nine episodes, being replaced by Bobby Ellerbee afterwards.
- Take That!: "Hetero-cephelo Agenda" features a parody of Chik-fil-A, a Georgia-based restaurant chain infamous for their founder's outspoken homophobia, called Chicken on the Cross.
- Write What You Know: Both of the shows creators Dave Willis and Jim Fortier grew up in the south, and base a large chunk of the humor off their experiences there.
- Write Who You Know: The creators have stated that when writing for Early, whenever he's making a decision they'll just have him do what one of their childhood friends would do...which isn't very flattering.
Trivia / Squidbillies