- Bad Export for You: There are some specific examples of this happening when Fallout 3 was exported out of North America to Australia and Japan with one attempt to India before the development team decided not to bother with it.
- Colbert Bump: Sales of Roy Brown's music on iTunes quadrupled shortly after the release of the game, which features his songs "Butcher Pete" and "Mighty, Mighty Man".
- Development Gag: Assuming the "Wasteland Survival Guide" quest ends with the guide's publication, the Lone Wanderer can snidely ask Moira Brown if she wants him/her to print and distribute the book, too. She replies it's not necessary. At one point you would have to get it printed — that's what the Hubris Comics building is for, if you were curious — but this got cut.
- Fake American: English Malcolm McDowell as President Eden and Northern Irish Liam Neeson as your dad James* .
- Fake Brit: American Charlie Warren as Allistair Tenpenny.
- Fake Irish: American Mike Rosson as Colin Moriarty.
- God Never Said That: It's commonly claimed, even on This Very Wiki, that Colin Moriarty's ridiculous Oirish accent is deliberately bad, as he's faking it to seem trustworthy. This is contradicted in-game by Herbert Dashwood, who reminisces in his terminal entries about when Moriarty first arrived in America as a child.
- Newbie Boom: This was the first main-line Fallout in nearly a decade, and the first from Bethesda Softworks, coming hot on the heels of their recent massive success and incorporating much of the same design, thus drawing many of those fans in. The resulting newbie boom reshaped the Fallout fandom forever.
- Playing Against Type: Paul Eiding has taken a break from voicing tough, commanding military leaders and badass, albeit eccentric grandfathers to provide a much softer performance for the various elderly men met in the game.
- What Could Have Been:
- A different game was going to be called Fallout 3, but it got cancelled. We now know this one as Fallout: Van Buren. More information on that one's page.
- According to the casting company that reached out to Liam Neeson and Malcolm McDowell for their voice roles, there was a brief period where Bill Clinton was seriously considered (and even approached) for the role of John Henry Eden.
- The Fat Man was supposed to have a rocket-propelled model of a B-17 airplane carry the nuke.
Trivia / Fallout 3