Hader and Wiig play twins Milo and Maggie, who have come together for the first time in years after both of them attempt suicide. Together, they confront their problems and what led to these events.
This film contains examples of:
- A Minor Kidroduction: The movie starts off when Maggie and Milo as kids on Halloween and their father gives them toy skeletons on Halloween.
- Armor-Piercing Response: Maggie and Milo dish these out to each other in a fight right after Maggie's husband leaves her due to Milo's meddling. Ultimately, Maggie gives the more painful response of the two:Milo: You're emotionally unstable.Maggie: You're a prick.Milo: You need professional help.Maggie: (scoffs) Oh, and this from someone who just tried to kill himself.Milo: Maybe I should try fucking all my problems away.Maggie: Well maybe next time, you should cut deeper!Milo: (doesn't say anything, but this has clearly hurt him.)
- Bittersweet Ending: Milo saves Maggie from her attempted suicide, and they appear to be working together to fix their lives, but as far as the audience is concerned, Maggie's marriage is over.
- Black Comedy
- Disappeared Dad: Milo and Maggie's dad committed suicide by throwing himself off a bridge.
- Driven to Suicide: Both Maggie and Milo, as well as their dad. But averted, finally, with Maggie and Milo.
- Insecure Love Interest: At one point, Maggie tells Milo that she thinks that Lance is too good for her.
- Mommy Didn't Show: Maggie and Milo's mother never showed up at Maggie's wedding.
- Oh, Crap!!: Maggie when Lance confronts her with the birth control pills shes been hiding.
- Rape as Backstory: It's eventually revealed that Rich (an adult teacher) had sex with Milo when he was 15 years old, but his family didn't press charges.
- "The Reason You Suck" Speech: Maggie gives one to her mother, regarding the latter's selfish behavior. Later on, she also gives one to Milo when she figures out that he's seeing Rich again, only for Milo to turn it around on her after her husband finds out about the birth control pills.
- Straight Gay / Camp Gay: Milo toes the line between the two. His speech does have a slight gay lisp to it and his clothing is a little sterotypical. His penchant for drag plays up an obvious stereotype.
- Rich, his former teacher and fling plays the Straight Gay Straight.
- Your Cheating Heart: Maggie has cheated on her husband with three men.