Relying heavily on 80s nostalgia and with some talented musicians working in it, such as Gerard Way and Mary J. Blige, the show manages to have a killer soundtrack full of classic 80s songs and alternative rock.
Season 1
- "Hazy Shade of Winter" in the official trailer, a rocking cover performed by Gerard Way himself.
- Lindsey Stirling's cover of "Phantom of the Opera"
starts out the series with Viktor playing elegant music before it ramps up showing how different all of Viktor’s siblings are, contrasting the violin to the rock music that accompanies it. - "I Think We're Alone Now" by Tiffany fits in perfectly with the first trailer. It also serves as a melancholic reminder of the siblings' communication issues as they always think that they're alone and is used in a scene where all the siblings are dancing separately.
- "Istanbul" by They Might Be Giants, played in the scene where Number 5 takes out a squad of Mooks in the doughnut shop, is a fun, upbeat song that makes the action-packed scene even funnier and more awesome.
- "Run Boy Run" by Woodkid in Number Five's flashback scene in episode 2 helps make the scene triumphant, and then very tragic. The episode itself is Titled After the Song.
- Paloma Faith's beautiful cover of "Never Tear Us Apart" in episode 2's last scene makes the scene even more heartbreaking.
- "In The Heat of the Moment" by Noel Gallagher's High Flying Birds opens episode 5 and is incredibly upbeat and catchy.
- Cha-Cha's actress, Mary J. Blige, does an amazing cover of Faces' "Stay With Me" which plays when Cha-Cha furiously burns down Agnes' doughnut shop in episode 8.
- "Mary" by Big Thief makes Klaus' return from 1968 all the more haunting.
- "Saturday Night" by Bay City Rollers, played during the scene in episode 10 when Luther, Allison, Diego, and Klaus run down the bowling lanes to escape the Commission hitmen, is insanely well placed.
- Episode 5 proves that "Ride of the Valkyries" is always awesome, even when played on a toy xylophone over a tinny ice cream truck loudspeaker.
Season 2
- Season Two kicks off with an epic use of "My Way" by Frank Sinatra accompanying the Umbrella Academy members fighting off the Soviet army in 1963 Dallas prior to getting nuked.
- Then, we watch as the Hargreeves are dropped into different points in the 1960s as "Right Back Where We Started From" by Maxine Nightingale plays in the background. It's peppy and humorous, but also a reminder that the siblings are apart again, just like they were in the beginning of season 1.
- The Backstreet Boys' "Everybody!" played during the fight wherein The Swedes went after Allison and Ray, will make you wanna rock your body too.
- “Dancing With Myself” by Generation X plays while Luther watches helplessly as teen Five fights 58-year-old Five, making for a very on-the-nose music choice.
- Episode 5, "Valhalla":
- Pogo's origin is told to the tune of "Major Tom" by Peter Schilling.
- The fight between Five and Lila is set to The Interrupters' awesome Ska Punk cover of Billie Eilish's "Bad Guy".
- Allison, Vanya, and Klaus get tipsy and dance in a beauty salon while "Twistin' the Night Away" by Sam Cooke plays.
- The Viking Funeral scene is set to My Kullsvik's Swedish language cover of "Hello" by Adele. It's so ridiculous that it's hard not to laugh.
- Pogo's origin is told to the tune of "Major Tom"
- Number Five murders a roomful of Commission board members with an axe while "Polk Salad Annie" by Tony Joe White plays in the background.
- Butthole Surfers' "Pepper" makes for a suitably psychedelic soundtrack to Vanya's trip after being forcibly administered LSD.
