- The 100: Veronica Mars, Edward and Alphonse Elric, Chris McLean, Jon Snow, Mavis, Harry Potter, Disgust and Gary Oak are teenagers who return to Earth from outer space after a nuclear apocalypse.
- The A-Team: Mr. Incredible, Shrek, Dale Gribble, and Hannibal are Vietnam War veterans who, after being falsely accused of committing a crime, drive around the country.
- Aaron Stone: Johnny Test is chosen to become a real-life video game character. Eliza Thornberry is aware of this.
- American Crime Story: Norm goes on trial for the murder of his ex-wife and her friend.
- Arrested Development: Garrett becomes head of the family company after his father Jean-Luc Picard is jailed. Now Garrett has to watch over his crazy family: son Finn, sister Blaineley (who married Scoutmaster Lumpus and gave birth to Blythe Baxter, whom Finn crushes on), mother the witch, and brothers Harry Solomon and Rufus.
- Austin & Ally: Izzy and Draco Malfoy are musicians.
- Alternately, young Kiara and young Kovu reunite in a band.
- Beauty and the Beast (1987): Eris starts a romance with Pinky.
- The Big Bang Theory: Rigby gets a new roommate: Brick. Magica DeSpell lives across from Rigby and Brick. Tina Belcher is their Funny Foreigner friend. One of Magica's friends is Fluttershy.
- Bones: Saddam Hussein and Marlene investigate murders. Selene is a forensic artist, L studies insects, Dean Winchester is L's apprentice, Towelie replaces Plankton as head of the forensics, and Tyson is a psychologist.
- Selene and L get married and have a child, while Tyson's sometime lover is Linka.
- Breaking Bad: After being diagnosed with terminal lung cancer, Dr. Doofenshmirtz produces crystal meth to save his future.
- Buffy the Vampire Slayer: Vanessa Doofenshmirtz (later Anne Maria) is a vampire slayer. Her sister is Chloe Carlson, while her friends are Ella (later Twilight Sparkle), and Titan (later Dante Hicks, then Ed). Vanessa is advised by Captain Planet (later Tenzin, then finally Dexter) to kill vampires.
- Castle: Novelist Charlie Harper teams up with Detective Olivia Benson. They fight crime with Kevin Ryan and Gauron.
- Chuck: Agents Rukia and Hank Hill have to protect Sirius Black, who knows some government secrets. Sirius' ex is Viper, and his long-lost parents are Quasimodo and Mary.
- Clarissa Explains It All: The life of Meg Griffin.
- The Cosby Show: The life of Cotton Hill, his wife Michelle Landau, and their four children: Nymphadora Tonks, Felicity Shagwell, Sam Winchester, and RTL!Haley Dunphy.
- Crash & Bernstein: Manny Delgado lives with his puppet Discord.
- Criminal Minds: T.J. Hooker, Earl, Rafiki, Joey Wheeler, and Bonnie Swanson are FBI agents who solve murder mysteries.
- Dawson's Creek: Mac, Tosh, Cady Heron, and Georgina Sparks are high school sophomores residing in Capeside, Massachusetts.
- Dexter: Smaug is a Serial-Killer Killer.
- Doctor Who:
- TV Movie: John Sheridan's Arch-Enemy is Blofeld.
- The Ninth Doctor: John Sheridan regenerates into himself. His companion is Laurel Lance. Her black friend is Varrick. Thor is an ex-Time Agent.
- The Tenth Doctor: John Sheridan regenerates into Light Yagami (later Jim Moriarty). After he loses Laurel, he travels with Catherine Holly and B'Elanna Torres. Blofeld's newest regeneration is Shinzon. B’Elanna Torres' grandfather is KITT. Thor now is Sirius Black.
- The Eleventh Doctor: Moriarty regenerates into Mike Traceur. His companion is Avatar Korra.
- The Twelfth Doctor: Mr. Dr. Possible travels with Rey. Shinzon regenerated into Panthea.
- Dog with a Blog: Sonic keeps a blog.
- Drake & Josh: The lives of stepbrothers Percy Jackson 2.0 and Gene Belcher.
- Everybody Loves Raymond: Bobo Haha (later Brian Griffin) is a sportswriter married to Miss Viola. Brian's parents are Albus Dumbledore and Roz, and his brother is Vector the Crocodile.
- The Flash (2014): The Eleventh Doctor (his father is Twelfth) got struck by lightning and became the fastest man on Earth.
- Alternately, Sonic still has superspeed.
- Fred: The zany adventures of Hiccup.
- Fresh Off the Boat: Tyrion Lannister, Azula, Clyde McBride, Bernie, and Emery are a Chinese family that moves to Florida. Loosely based on Clyde's autobiography.
- The Fresh Prince of Bel-Air: Tarzan (later Soos) got in one little fight and his mom Marge Simpson got scared, and said "You're moving with your auntie Mittens (later Molly Weasley) and uncle Garrett Boydston (later Dirty Harry) in Bel Air." Also starring Tarzan/Soos' cousins Steve, Claudia (later Leela), and Kiara); and the butler Master Splinter (later Birdbrain).
- Friends: Phoebe Halliwell, Judy Neutron, Riza Hawkeye, Adam Savage, Wolverine, and Raj are six friends in their 20s living in New York City.
- Game of Thrones: Gloin until he's killed, his wife Professor Trelawney until she's killed, and his best friend Louis until he's killed deal with deadly intrigue in a crapsack Low Fantasy world, most of it coming from Louis' wife Bones and her brothers, Naraku and Christopher Robin.
- Max Russo is an epically Royal Brat until he's killed.
- Ronan the Accuser is a Barbarian King until he's killed. He's married to Ikki.
- Glee: Bonkers reinstates a high school glee club with Sailor Moon, Starfire, Samey, Tombo, Daenerys Targaryen, Danny Phantom, fallen quarterback Eugene, and Naruto, among others. Later on in the show, Bonkers marries Ginormica. While Smaug is the original coach of the glee club, Jenny Gump is a cheerleading coach.
- Gossip Girl: The new Odette is an omniscient blogger who narrates the lives of high-class New Yorkers Kiki, Ursula, Jo-Jo, Jason Stackhouse, Harvey Kinkle, and Cho Chang.Eventually we learn that Jo-Jo is Odette's true self.
- Grey's Anatomy: Daphne, Rarity, and many others work at a Seattle hospital.
- Hannah Montana: Lisa leads a double life as a pop star.
- Heroes: Lucifer is blessed with super strength. Chum-Chum can absorb others' powers, and his brother Hank Hill is given flight. Trixie's still great and powerful now that she's nearly indestructible; at first only Rekuta is allowed to trust Trixie's secret. Trixie's adoptive father MacGyver is caught up in a conspiracy. Tortured by her father Vladimir, Katara switches over to electricity bending. Alex is a psycho watchmaker. There's Nancy Gribble creating illusions.
- How I Met Your Mother: Nephrite tells his children (the daughter is Sally) the story on how he met their mother. Friends include Tom, whose wife is Roberta Tubbs, and Dexter.
- iCarly: Connie, her friends Velma, and Conan Edogawa host a web show. Connie's older brother is Flynn Rider.
- I'm in the Band: Aaron Samuels, whose friend is Karen Smith, joins a band, which consists of Duncan, Owen, and Brick.
- Jersey Shore: Ella is one of eight housemates on this reality show.
- Jessie: Cat Valentine is the babysitter for May (later Mavis, then Amethyst), Luke, Darwin, and Agnes. Grunkle Stan is the butler.
- Jon & Kate Plus Eight: Daphne and Zelgadis live with their eight children.
- Kenan & Kel: The comedic adventures of Oscar and Hiccup.
- Knight Rider: Voldemort drives a Cool Car named Oogway.
- Lab Rats: Carlos moves in with his stepfather, the Tenth Doctor, and discovers three bionic teenagers, Robin (later Adrien), Nino and Lila living in his basement. Mandark (later Zhao) is a home automation.
- LazyTown: Zapp Branigan and Amy Wong have to stop Nigel from stopping their healthy activities. Amy's uncle Stan Smith is mayor.
- Legends of Tomorrow: Archer recruits a team of superheroes: Geoff, Don, Taylor, Amy Pond, Hercules, Jax, Hercules, and Neo. Disney!Hercules sacrifices himself to destroy the Time Masters. Taylor and Geoff drop out after the team kills Tom Tucker.
- Lizzie McGuire: The Test Sisters experience life in their own perspective:
- Lost: Candy Barbarian, Aziz (later Tuxedo Mask), Spike, Donatra, Gil, Applejack, Near 2.0, Raye Penber, Lawrence Fletcher, Charlotte York, Stifler's Mom, Nate, Angel Batista, Dexter Morgan, Susan Ivanova, Wooldoor Sockbat, Kate Gosselin, Bob (later Mr. Krabs), and a few others get stranded on a deserted island, after a plane crash. In the end, Candy, Spike, Donatra, Angel, Dexter, Near 2.0, Krabs, Lawrence's son Ben Tennyson, and some others survive. The original James doesn't seem to age.
- Malcolm in the Middle: Bambi is an average kid who lives with his brothers Harvey Beaks,Steven Universe and the original Mac. The new Mac is Bambi's friend. Eudeal and Mr. Nelson are the boys' parents.
- Harvey marries Sakura Haruno halfway into the show.
- Married... with Children: The show follows the lives of businessman Mr. Incredible, his wife Galadriel (later Rebecca Cunningham), and their children Shingo Tsukino and Naru.
- The Middle: Harold is the older brother in both versions.
- Modern Family: Gus adopts a Vietnamese girl in all adaptions.
- HBO version: Sabretooth restarts life by marrying Nani Pelekai, whose children are Jon Snow and a baby. Sabretooth's daughter Sally is married to Peter. Their children are Sam, Alex, and Barry Guller (later Norman Babcock). Perry Babcock and Gus adopt a Vietnamese daughter named Renesmee Cullen.
- RTL2 version: Al Bundy remarries the redubbed Georgette, whose oldest son is Oliver in that same dub. Al's daughter the original Odette is married to Jimbo Kearn, whose children are Courtney Babcock, Sue Heck, and the third Gordie. Kick Buttowski and Gus adopt a Vietnamese girl named Rosie.note
- Comedy Central version: Al remarries Helena, whose oldest son is Steven Universe. Al's daughter Daphne is married to Daryl Morris. Their children are Sue, Norman (who later became Scaredy Squirrel), and Isabella. Gus, Kick, and Rosie reprise their roles from the RTL 2 dub.
- Monk: Don Karnage is a nervous detective who is allowed to work again under police chief Ka D'Argo and with the naive Aang. Karnage's assistants are Deanna Troi and April Curtis.
- My Babysitter's a Vampire: Yang learns that his babysitter Jasmine is a vampire. Yang's best friend is Jerome.
- My Name Is Earl: Knockout is trying to make up for the wrongs of his past. His ex-wife and brother are Leela and Mr. Conductor. The brothers' old friend Discord is still getting into mischief, even landing in jail.
- The Nanny: Lois Griffin is a simple Jewish girl from New York, who becomes the nanny for Ironhide's (later Ben's) children Randall (later A.J.), Carly (later Veruca Salt) and Patsy Smiles. Sue Sylvester is Lois' rival, and Ben's butler is Grugg.
- NCIS: Gibbs leads a team of FBI investigators, consisting of Slade, Gloria, and Gunther. Monk is the agency director.
- NCIS: Los Angeles: Brandon Walsh and Wakko Warner fight crime, mentored by Madame Foster.
- Nip/Tuck: Spider-Man is a plastic surgeon. His co-workers include Stewie, Chris, Pinkie Pie, Nightmare Moon, CC Babcock, Blaineley, Izzy, Lucifer, and Mrs. Weasley. Peggy Hill works in an organ theft ring, then she buys out Spidey and Stewie's Miami branch.
- The O.C.: Shining Armor moves into his lawyer Earl's home. Earl's wife Penny is suspicious of the new houseguest, but their son Finn Hudson quickly befriends the new pony in town.
- Talk about a love triangle! Shining Armor falls for adult Kiara, and Finn secretly crushes on Kiara's friend Dakota (who instead takes a liking to Shining Armor).
- Once Upon a Time: Evey Hammond struggles to understand that she is living in Boston. She is aided by her son Wyatt Bernstein, who is also Teyla Emmagan's (whose half-sister is Sam Carter/Replicarter) son. Walter White (whose love is Lydia Rodarte-Quayle) brings magic into Storybrooke.
- Also starring the likes of Batman, Quentin Costa, Tyrion Lannister, Will, Steve Rogers, Milo Thatch, Candace Flynn, Harold Buttowski, Alix Kubdel, Alex Brandt, Quentin Lance, Geordi La Forge, Sam (later Dr. Caitlin Snow), Alex Russo, among others.
- One Tree Hill: 2018 Donatello and 2003 Donatello are rival half-brothers on the same basketball team. Because his childhood friend Mitsuki married 2003 Donatello at the end of season 1, 2018 Donatello is involved in a love triangle between his long time crush Miranda and her best friend Lana Lang.
- Parks and Recreation: (DreamWorks Animation style) The Fairy Godmother and Lord Shen work for the Missing Link's parks department.
- Psych: Alex pretends to be psychic. Even his co-worker Iolaus, and his love interest Sailor Venus are aware of it.
- Reba: The life of single mother Ms. Mimi.
- Sabrina the Teenage Witch: Princess Calla (later ?, then finally Teletha Testarossa) is a teenage witch.
- Scrubs: Captain America, Trent, and Odette rise from hospital interns to young attending physicians. Linda retires in season seven, and becomes a professor. By the series finale, Captain America and Odette get married, while Trent and his supervisor Lana Kane start a family.
- Seinfeld: The misadventures of Yamcha and his friends Hong Kong Phooey, Charlotte, and Dick Solomon. Yamcha's rival is Flem.
- Shake it Up: Mavis and Bella Swan, with the help of Jake and Gene, are dancers on a local TV show.
- Shameless: Elastigirl is raised by her alcoholic father Mr. Ping.
- Sherlock: Tulio and Bloo fight crime in modern London. Tulio's brother is Steve Rhoades. Hawk Moth is a inspector.
- Tulio's Arch-Enemy is the Tenth Doctor. Commander Rourke is a blackmailer.
- Smallville: Noah is a young man with superhero abilities who is adopted by Afro Samurai (later Tulio, then Sportacus). Pops pulls a Heel–Face Turn later on in the series, and becomes arch enemies with Noah. Gollum is a cyborg who wants to destroy humanity.
- Damn, the death tolls are high: Panic joins the marines and dies in action; Pops kills his father Lawrence Fletcher; John Connor is crushed by a meteor; Stefano kills Solf J. Kimble with a metal pipe. Stefano is then killed by Marissa Cooper.
- So Little Time: Diamond Tiara and Sweetie Belle are twin sisters.
- Sonny with a Chance: Numbuh 5, Wendy, Justin Russo, Isabella, and Wilbur Robinson host a Comedy Show Within a Show, with Luke Skywalker (later Linda Belcher). Tina Belcher, Alex and Kagome are the guest stars; Merlin is their rival; and Peggy Hill is Numbuh 5's mother.
- Stargate SG-1: Davy Crockett (later Batman) leads a team of scientists and military explorers, including military scientist Tracey Abernathy (later Dr. Julia Heller then Shmi Skywalker), alien James Ferguson (later Tony Stark (The Iron Jaffa) then Mason Makoola), and the archaeologist John Crichton (later Jerry Russo). The SGC leaded by Fred Flintstone, and the base doctor is Thea Stilton.
- Durning the last two season the SGC is led by ALF (later Jerry). John Doggett and Poison Ivy join the team of explorers.
- Stargate: The Ark of Truth: The SG-1 travels to the Ori galaxy to defeat Rosalie Hale. Plankton is the Doci. The Joker is a IOA agent. Ty Lee is an ascended.
- Stargate: Continuum: The mayor of Pejite is a Goa'uld who creates a new timeline. Batman is now James Bond, and Poison Ivy became Jenny Calendar. Captain Kirk is the president.
- Stargate Atlantis: Hope van Dyne leads an expedition in the Pegasus Galaxy. Cyborg leads a team including Regina Mills, Stewie Griffin and Peter Griffin. Cleveland Brown is a Scottish doctor. Gabriel Agreste is a Czech scientist.
- After Stewie escapes from Atlantis, Max Bergman joins the team. Ty Lee replaces Cleveland after he explodes.
- After Hope does a Heroic Sacrifice the new leaders of the expedition are Shmi (Season 4) and Batman (Season 5).
- The Genii leaded by Mojo Jojo until he's killed.
- In an episode Peter shares his body with Raava.
- Star Trek: The Next Generation: Davy Jones (later Walter Skinner), Bugs Bunny, Maes Hughes, Tasha Yar, Al, Beverly Crusher, her son Miroku, the original Xena, and Mr. Chang (later Iron Will) are adventurers.
- Star Trek: The Original Series: Peter Venkman (later Magnum, P.I.) explores the galaxy alongside his crew which includes Steve Rhoades, John Locke, and Po (later Mickey Smith).
- The Suite Life of Zack & Cody: Young3!Andy and his brother Rudy cause misadventures in the hotel, where Mabel Pines and Doc Holliday work at.
- Supernatural: Brothers Edward Elric and Ron Stoppable fight the paranormal.
- Survivor: A Sziget
: John Bennett hosted the short-lived Hungarian version of this reality show. - Teen Wolf: Gabumon is a teenage werewolf. His best friend is Speedy Gonzales, his love interest is Fatmagül, and Orochimaru is a mysterious werewolf.
- Teletubbies: The lives of Lord Shen, the first Mandark, the original Carrie, and Mai. Narrated by Voldemort.
- Terminator: The Sarah Connor Chronicles: Agent Perez is on the run with her son Cameron and Cindy Vortex.
- That '70s Show: Bobby Hill is a Funny Foreigner kid, while Chris is the main character. Gideon is something of a Dumb Jock.
- 3rd Rock from the Sun: Vladimir, the original Sadie, Tai, and George Michael are surprisingly human aliens. Mrs. Weasley is a professor.
- Tru Calling: Pepper Clark works at the city morgue, repeating the same day to prevent murders.
- True Blood: Sam Sparks and her brother the Eleventh Doctor discover that vampires really do exist.
- Two and a Half Men: Jon Arbuckle and Bartok are two brothers. Phineas is Bartok's son. Patrick Winslow replaces Jon after he gets hurt between seasons eight and nine.
- The Vampire Diaries: Ginormica lives with her aunt Sandy Cheeks and brother Ash Ketchum. Ginormica later gets caught up in a love triangle with the vampire brothers Brick and Sportacus. Ginormica's friends are Twilight Sparkle and Diamond Tiara, and her father is Mario.
- Veronica Mars: Blair Waldorf fights crime with her father Hal. Scott is a bully.
- The War at Home: Dolly and Crash raise their crazy-ass kids (including Gretchen and Jonathan).
- Will & Grace: The relationship between Brian Griffin and Kim Possible.
- Win Lose And Draw (2014): Vicious, Tommy Turnbull, Tyler, Dawn, Robin, Carl, Candace, Lizzie McGuire, Miranda, Connie, Miko Nakadai, Hermione Granger, Jane Morgan, Sam Puckett, and several other young contestants compete in a game show. Hosted by Kurt Hummel.
- Wizards of Waverly Place: Ferb, Hannah Montana, and their older brother Sokka 2.0 do magic. Peggy Hill and Joey are their parents.
- Xena: Warrior Princess: Deanna Troi (later Gwen) and Linda go on adventures as warriors.
- The X-Files: Sarah Jane Smith (later Stella) and Bolt are spies.
- Z Nation: In the middle of a Zombie Apocalypse, a team of survivors has to transport Mad Max from New York to a Center for Disease Control in California. After Zenblock gets killed off, Ellody takes over as the leader of the pack. Jimmy Neutron watches over the team.
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