When Douglas Adams revealed that the question which produced the Ultimate Answer (42) was What do you get if you multiply six by nine?, somebody pointed out that the math actually did add up... if you use base 13. Adams responded, "I may be a sad individual, but I don't make jokes in base 13."
Stanley Howler from the Discworld book Going Postal is so obsessed with his pin collection, even the other pin collectors in Ankh-Morpork think he's "a bit weird about pins". Then Moist von Lipwig invents the postage stamp, and Stanley proceeds to obsess over those, inventing stamp collecting (and becoming incredibly dismissive about people who are "still" collecting pins).
Live Action TV
Arnold Rimmer from Red Dwarf is practically an Extraverted Nerd except for the fact that he's in his mid-20s/early 30s, but is the first member of the team to throw out insults comparing his crewmembers negatively to various nerds. Even getting his negativity drained by an Emohawk and turning him into Ace Rimmer doesn't stop him from proclaiming Dwayne Dibbley (Cat with all his "Coolness" drained out of him) to be "so geeky he couldn't even get into a science fiction convention".
When Buffy fails to get on the cheerleading squad early in Season 1, her mother suggests that she join the yearbook staff. Buffy responds, "Have you seen the people that work on the yearbook? Nerds pick on them."
Even more reviled than a typical roleplayer is a roleplayer who insists on roleplaying. When the dorks need to feel superior, this is the guy they denounce as a dork. Honestly. The only person worse than him is the DM himself.
In thisCtrl+Alt+Del strip, Ethan said that Lucas had "crossed over into the realm of supernerds, whereby even regular nerds steal your lunch money and throw rocks at you" over his excitement on having discovered the A Song of Ice and Fire CCG.
She also has a few obligatory swipes at LARPers in her Labyrinth review.
Yahtzee of Zero Punctuation describes EVE Online players as "the nerds who are to nerds what nerds are to normal people", with an appropriate series of illustrations.
Another time he mentioned he wasn't as into a franchise as others and said, "This is where the big nerds get to pick on me" with an illustration of a hulking figure with big coke-bottle glasses and nerdy incisors picking him up.
Graham: They're LARPers. It's like what Jer does with the dice and the bits of paper, except that the people Jer hangs out with look down on these guys.
The Cracked series After Hours is entirely about four geeks who sit around a diner discussing pop culture as Serious Business. Nevertheless one of them, Daniel O'Brien, is even geekier than the others and tends to get a lot of looks of mixed confusion/scorn/pity when he says something particularly nerdy. It's Self-Deprecation, of course, Dan is the show's writer.
In Doppelganger, nerds form an entire clique. Even they consider Victor too nerdy to join them.
The nerds won't even tolerate me!
Ironic, yes, but still it really hurts.
Seanbaby once posted an old Nintendo Power letter on his website, in which a group of college students discussed how they spent Spring Break playing Gameboy... and the editor's response was "You know, Gameboys also work outside." Seanbaby couldn't let the chance pass:
"When a guy whose hobbies include 'play-by-post games' looks up from his Dungeonmaster's Guide and tells you you're a geek, you know you're finished. You might as well knock your own lunch tray out of your hands and save us all the time."
Lisa:(picks up a pencil holder) Ooh, I want to get the krünk. Marge: Mmmm, you don't want something that overshadows the pencils. (holds up another pencil caddy) How about this pöpli? Lisa: Mom, no! Everyone at school picks on the pöpli kids - even I do. (under breath) Just hate them so much.
And when Bart accidentally revealed that he has a stamp collection, even Lisa laughed at him.
Family Guy: Meg, the outcast and loser member of the Griffin family, refuses to date Neil Goldman, an equally geeky outcast of a classmate of Meg's whom Meg finds annoying and a clueless loser. Apparently, the butt-ugly Meg — forever wanting to have sex with desirable football hunks and other desirable young men — doesn't believe in "beggars can't be choosers."
Not everyone blames Meg for this, since her "butt-ugliness" is largely an Informed Deformity, unlike Neil's.
In The Fairly Oddparents younger Cosmo, who is apparently the biggest loser in his school, gets beat up by every clique group, even the nerds.
In the South Park episode "Return of the Fellowship of the Ring to the Two Towers", the kids are playing like they are characters in The Lord of the Rings, but Cartman then makes fun of kids who are playing like they are in Harry Potter.
In the end of the Danny Phantom episode "Lucky in Love", the nerd calls Danny, Tucker, and Sam "losers".
In the early season, Tucker himself hates being called a "nerd" and "Techno-Geek". In one episode, he has gotten sick of it, but by the end he started to like being a "Techno-Geek".
Total Dramainverts this—according to his online bio, the reason Cody thinks of himself as cool is because he hangs out with a bunch of friends even geekier than he is.
In The Looney Tunes Show, there's a flashback to everyone's high school days, and we find out that even Pete Puma and Marvin Martian, established losers in this particular continuity, refused to sit with Daffy.
This is a common theme in Codename Kids Next Door where nerds actually seem to have superhuman powers that set them apart from other kids. (Like turning into zombies if you steal from them.) In any case, nerds are quick to compete with other nerds over their talents, like in one scene where a nerd calls another one dumb when he doesn't know that he can't catch cooties from his sister.