Mad Scientist / Western Animation

Mad Scientists in Western Animation.

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• 101 Dalmatians: The Series: P.H. De Vil, Cruella's cousin who she often collaborates with to carry out some of her schemes. He's usually inventing some kind of device to accomplish some evil deed, such as an earthquake machine, a personality splitter, and a robotic version of Rolly. He is also willing to test dangerous chemicals on animals without any consideration of the harm he may be doing to them.
• Adventure Time:
  • Princess Bubblegum is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and peace-loving, she has accidentally unleashed a zombie plague twice, created a number of artificial life-forms (including all the citizens of the Candy Kingdom, a giant immortal candy sphinx named Goliad who almost destroyed the kingdom, and the tyrannical, emotionally-unstable Earl of Lemongrab), has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts imprisoned on spurious charges just because she was mad about him compulsively eating her pudding stash, and was prepared to torture the Ice King in order to get a cure for the outbreak of "freezer-burn flu" he accidentally unleashed. Her "For SCIENCE!" attitude, and her devotion to protecting her kingdom, cause... interesting things to happen.
  • Assuming that he was the one who designed and built the Reconditioning Chamber and the Sound Sword, then Lemongrab definitely qualifies.
  • "Preboot" introduces Dr. Gross, a refugee from the last surviving colony of humans on Earth who combines an obsession with creating mutant cross-bred animals and cyborgs with a rather lax attitude towards getting consent from her test subjects.

• The Alvin Show has Clyde Crashcup, who tries (but always fails) to "invent" something.
• Dr. Weird from Aqua Teen Hunger Force.
  Dr. Weird: Gentlemen! I have created... this thing.
  Steve: What is it?
  Dr. Weird: I don't know! Stand over here.
  Steve: What, over here — hey!
  Dr. Weird: It works! I am one can short of a six-pack! (Evil Laugh)
• Arcane:
  • Singed is a chemist and biologist who assisted crime lord Silco in creating shimmer, a drug that enhances its users' strengths and durability while turning them into violent hulking beings.
  • Jinx is an engineer who uses scraps she could find to build her weapons and recreate Jayce's first Hextech experiment.
• Archer: Doctor Krieger. Some of his creations include "Fister Roboto", a fully intergrated multi-fetish artificial being, and an irradiated pig named Pigley III who eats people. He was also responsible for rebuilding Russian agent Katya Kazanova into a Cyborg and built Ray Gillette his robot arm.
• Dr. Gangrene in Attack of the Killer Tomatoes!, the creator of the eponymous Killer Tomatoes. Defied by the man himself however,
  Dr. Gangrene: I'm not a mad scientist, I'm an angry scientist!
• The Dark Knight always seems to be neck-deep in mad scientists in Batman: The Animated Series. Within the first five episodes of the show, he runs afoul of Man-Bat, the Scarecrow, and Poison Ivy, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who called his sanity into question... which should answer the question of his sanity quite comprehensively.
• The Beatles have come across a couple of mad scientists. Professor Psycho (from "Baby's In Black") brings a vampire girl to life and tries to get her married to Paul, while Dr. Dora Florahyde ("If I Fell") wants to transfer John's thoughts into her Frankenstein's Monster to bring it to life. (This was unintended as the doc told The Igor to get the brains of a beetle. Igor responded that John is "the brains of the Beatles.")
• Ben 10 has Doctor Animo, the very much insane scientist whose goal is to mutate the entire population of the Earth, humans and animals alike, into monstrosities as one of Ben's most persistent enemies.
• Biker Mice from Mars:
  • The original 1993 series has Dr. Karbunkle, who often creates inventions for Limburger and his minions to use against the Biker Mice and also experimented on the Biker Mice, which resulted in Modo getting an eye-patch and a robotic arm and Throttle being blinded and needing special sunglasses to see.
  • The 2006 Sequel Series has Dr. Catorkian, a Catatonian scientist who creates inventions to help the Catatonians and Ronaldo Rump defeat the Biker Mice.
• Captain Planet and the Planeteers: Dr. Barbara "Babs" Blight is an insane, yet brilliant scientist, and represents unethical scientific research and technology in the wrong hands. Sometimes, though, she simply causes environmental damage for the sake of doing so. Some of her plans have a Freudian Excuse related to her facial scar, which can actually make her Unintentionally Sympathetic to some viewers. It's a pity that Gaia, the only character in the show who has healing powers, is the one Blight would never be willing to ask for help. Instead, she has tried to kill or at least harm the Spirit of Earth quite a few times.
• Chip 'n Dale: Rescue Rangers: Professor Norton Nimnul, who frequently creates inventions to cause trouble that the Rescue Rangers have to stop.
• Classic Disney Shorts:
  • Dr. Frankenollie in Runaway Brain creates a Frankenstein Monster resembling Pete named Julius and invites Mickey Mouse over so he can have his creation and the hapless rodent switch brains.
  • A much earlier example is Dr. XXX, the title character of the 1933 short The Mad Doctor, who kidnaps Mickey's dog Pluto with the intent of putting the dog's head on the body of a chicken.
• Clone High: Dr. Cinnamon J. Scudworth certainly qualifies. While his day job is principal of the eponymous school, he's also the scientist who created all the clones of historical figures attending Clone High. He's also certainly got the "mad" part down, being generally characterized as a wacky Cloud Cuckoolander.
• Code Lyoko: Franz Hopper is less "mad" than he is "slightly unhinged". Still, though, he manages to create a computer program that can venture into the world, take people hostage, create poisonous gas, create blizzards, and many many other things, so he definitely counts.
• Codename: Kids Next Door has a couple, including Chester and Professor XXX-L.
• Courage the Cowardly Dog has Di Lung, a scheming Gadgeteer Genius who often causes trouble for Courage and his owners with his unusual inventions.
• C.O.P.S. (1988): Dr. Badvibes is the Gadgeteer Genius of Big Boss' criminal organization.
• Darkwing Duck:
  • Megavolt is deranged and frequently has plans that involve using his inventions to manipulate electronic appliances.
  • Bushroot is a botanist who mutated himself into a duck/plant hybrid.
• Dexter's Laboratory:
  • The main character Dexter is a kid scientist and isn't above conducting unorthodox experiments.
  • Dexter's rival Mandark is also a boy genius and is often shown to be less scrupulous than Dexter.
• The Dick Tracy Show has the Brow and Oodles in possession of Dr. Von Stooker's notebook which has a formula to turn people invisible ("Lab Grab"). Joe Jitsu plants a phony book on the crooks, with the resulting mixtures they make turning into Gargle Blaster stuff.
• Freakazoid! has the title character's Arch-Nemesis The Lobe, as well as the guest villain Dr. Mystico (played by Tim Curry!). Mystico is notable for being not only traditionally "mad", but also something of a Cloud Cuckoo Lander to boot.
  Freakazoid: (Makes a "he's crazy" gesture with his finger)
  Dr. Mystico: I saw that!
  Freakazoid: Saw what?
  Dr. Mystico: That! (Copies the gesture) You think I've got a clock in my head, don't you!?
• Futurama: Professor Farnsworth takes this to the lengths of parody and beyond, casually creating doomsday devices, atomic supermen and hybrid lifeforms, experimenting on himself, and being several forks short of a silverware drawer.
  • He builds Doomsday Devices a lot. Oh, he doesn't plan to use them, he just seems to think they're cool. "I suppose I could part with one and still be feared..."
  • At one point the Planet Express crew were figuring how to enter New New York's Central Bureaucracy.
    Prof. Farnsworth: You can't just waltz into the Central Bureaucracy! It's a tangled web of red tape and regulations. I've never been, but a friend of mine went completely mad trying to find the washroom there.
    Leela: Then we'll need a guide, someone who's been there before.
    Prof. Farnsworth: Oh, I've been there. Lots of times! [laughs maniacally]
  • One episode revealed that he spent twenty-five years in a mental institution starting when he was a teenager. His rival and former student, Professor WERNSTROM! is of the evil (or at least asshole) variation.
  • Leonardo da Vinci also counts.
• Garfield and Friends: One builds the Incredibly Stupid Swamp Monster. How mad is he?" asks Roy. "He's so mad," replies Orson, "he spent ten years trying to cure his pet cat's measles before realizing it was a leopard."
• Nathan from The Garfield Show is a child mad scientist whose nefarious inventions have caused problems for Garfield on more than one occasion.
• Gargoyles: Dr. Sevarius isn't quite mad so much as he is amoral, but he displays a touch of the theatricality that is the hallmark of the best nutty professors.
• Generator Rex: Cesar single-handedly invents weaponry that can take down an entire highly-trained government base, but is a Cloud Cuckoo Lander on a good day and a totally lacks any sense of practicality or ethics on a bad day.
• G.I. Joe: A Real American Hero: Dr. Mindbender serves as Cobra's chief scientist, his most notable contribution being the creation of the terrorist organization's second leader Serpentor.
• Grojband has Kin Kujira, The Smart Guy and Gadgeteer Genius of Grojband whose obsession with creating usually dangerous inventions (that often he tests on his friends) sometimes borders on making him a Creepy Child.
  Kin: I think I can build something that can help us... or cause untold horrors! [Evil Laugh]
• The Head: Not how the trope usually plays out, as he's a Punch-Clock Villain rather than a Diabolical Mastermind, but Dr. Elliot starts out as a Cloudcuckoolander and just gets worse from there, to the point that his mooks eventually mutiny against him.
• Inside Job (2021):
  • Villain Protagonist Reagan Ridley is a Gadgeteer Genius working as a team leader for an Evil, Inc. run by The Illuminati to help administrate their control over the free world. She's more on the Affably Evil side of the spectrum, but her Cloudcuckoolander tendencies and lack of social skills have resulted in a mountain of HR complaints about actions such as terrorizing her coworkers with a mecha for forgetting to fill out their time cards.
  • Reagan's cohort Dr. Andre Lee is a free-spirited Mad Doctor and head of their biochemistry department. He's a Functional Addict who spends most of his time high on whatever he can get his hands on and doesn't concern himself with the ethical ramifications of things like implanting a subdermal Shock Collar in the President of the United States to make him a more effective Puppet King.
  • Reagan's father Rand was her predecessor at the company but was fired after he had a mental breakdown that resulted in him attempting to destroy the Sun (which he justifies by saying he was going to end skin cancer) and almost blowing their cover. Nowadays he's The Alcoholic Cloudcuckoolander who spends his time finding creative ways to piss off his old boss, such as turning Reagan's robotic replica of the President of the United States into a President Evil or starting a YouTube channel exposing various conspiracies but acting crazy enough that nobody believes him so he's more of an inconvenience than an actual threat to the organization.
• One episode of Inspector Gadget features the M.A.D. Scientist — that is, a scientist who works for M.A.D. However, he gets really, really peeved when someone calls him a mad scientist, screaming, "I'M NOT MAD!"
  "I'm not MAD! I'm Dr. Focus! [gets arrested] Now I'm really mad!"
• Invader Zim:
  • The title character is a mad scientist himself. In fact, in a script for an incomplete Start of Darkness episode about him, Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.
  • Dib and Professor Membrane are also Mad Scientists, albeit less on the evil side than Zim. Dib is perhaps Madder, since his inventions revolve around his all-consuming obsession to destroy ZIM, whereas his father's inventions are more geared toward helping humanity (even the Super Toast).
• Jellystone!: No sane doctor would even consider half of the things Cindy Bear comes up with. Her innovations do work the way they're intended to but the purposes she creates them for aren't exactly conventional or necessarily ethical. She complains in "Squish or Miss" about the ethics board prohibiting one of her experiments.
• Jimmy Two-Shoes:
  • Heloise. Despite appearing as a cute little girl, she is a sadistic evil genius who makes destructive inventions to spread misery, conducts torturous experiments on others, and likes to destroy things for fun.
  • Heloise isn't the only one in Miseryville (the town even has an award ceremony just for them). One recurring character is Dr. Ludwig Von Scientist, a German-accented evil genius of a demon who's got more forehead than body. He's usually just the go-to "evil scientist" character when Heloise isn't available, but in "Heads Will Roll" he's shown to be Heloise's arch-rival and the only one who comes somewhat close to being as good of a mad scientist as her.
• Johnny Test's older sisters Susan and Mary are both Mad Scientist teenagers. Also their friendly enemy, Eugene, a.k.a. "Bling Bling Boy".
• Jonny Quest:
  • Dr. Ashida in "Dragons of Ashida", who uses genetic engineering on lizards to increase their size and also has a maniacal laugh.
  • In "Terror Island", Dr. Chu Sing Ling uses a chemical to grow gigantic versions of normal creatures.

• The Ultra-Humanite from Justice League has all the characteristics of the traditional, cultured Mad Scientist — with an emphasis on 'cultured'.
  Ultra-Humanite: [giving an educational toy to a group of orphans] I welcome any opportunity to bring culture to the uncorrupted.
• Kaeloo: Olaf, who is bent on trying to Take Over the World. He builds robots which he uses to attack people and doesn't think twice before kidnapping Stumpy and turning him into a cyborg against his will.
• Kim Possible: A fairly large share of the Recurring Characters, notably major antagonist Doctor Drakken. Even some of the good-guy characters (such as Kim's father and brothers) have mad-scientist tendencies.

• The Legend of Korra: Varrick, although he's less cacklingly crazy and evil and more quirky and amoral.

• Milton the Monster: Professor Weirdo and Count Kook create a monster with six drops of essence of terror and five drops of sinister sauce. Professor Weirdo means to add a tincture of tenderness so the creation would not turn on him, but Count Kook accidentally knocks in the entire beaker. The creation becomes the childlike Milton.
• My Life as a Teenage Robot: Most of Tremorton’s citizens think that Nora Wakeman is this. While she is more saner then most of the examples listed, some of her inventions don’t seem to serve a true purpose.
• My Little Pony 'n Friends: The gizmonks, from "The Great Rainbow Caper", are obsessed with invention and experimentation for their own sake, gleefully cobbling together complex machines for no real reason or gain, and sometimes without even knowing what they're supposed to do.
• The New Adventures of Speed Racer:
  • Dr. Norbius, a competitor of Pops Racer who sells his inventions to terrorists.
  • Dr. Brainbiter traveled back in time to the Jurassic to acquire a rare mineral that would allow him to mind-control the human race.
• Phineas and Ferb:
  • Dr. Doofenshmirtz is an Affably Evil Punch-Clock Villain trying to conquer the Tri-State Area. He insists on being called an evil scientist, considering "mad scientist" a slur. His alter ego from the 2nd dimension was one, but now serves as the dictator.
  • Phineas and Ferb themselves, actually. They do build things like city-spanning roller coasters, time machines and space ships after all, and landscapes in their backyard. Two of the sweetest, friendliest mad scientists you'll ever meet, but still.
  • With Phineastein, the Regurgitator, Professor Poofenplotz and all the members of L.O.V.E.M.U.F.F.I.N., it seems the show runs on this trope.
• The Brain of Pinky and the Brain always devises a scheme to take over the world, several of them involving machines and potions. He quite often pilots mechanical bodies to appear human and once tried to hypnotize everyone by feeding them pancakes laced with hypnotic fluid.
• PJ Masks: Romeo, a Child Prodigy with a knack for creating evil inventions and planning to take over the world.
• The Powerpuff Girls (1998):
  • Mojo Jojo sometimes tries to stop the girls using devices of his own invention and actually laughs maniacally several times. Also, he's a monkey.
  • Professor Utonium, although he's far more benign than most. Every time he creates something useful (including the Girls themselves), it's by accident. But when he tries to do something intentionally, it leads to a disaster.
• Randy Cunningham: 9th Grade Ninja:
  • McFist's Dragon, Willem Viceroy III. To the point that he literally attended a college called "Mad Scientist University" (MSU for short) and was even valedictorian of his graduating class.
  • Mrs. Driscoll's husband Jerry Driscoll, back when he was alive. In fact, he was in the same class as Viceroy at MSU and his primary rival for valedictorian. Viceroy got him arrested in order to take him out of the competition, and he died not long after. When he's briefly revived by Randy in "Dawn of the Driscoll", he tries to complete the "destroy the world" Doomsday Device he was building in college in order to become valedictorian of his class, completely unaware of how much time had passed since his death. He only gives up after he finds out the truth from Mrs. Driscoll. And then claims it's time to get started on his "destroy the universe" Doomsday Device. It's at this point Mrs. Driscoll requests Randy turn him back to normal.
• Rick Sanchez from Rick and Morty is as mad as they come, though he replaces the usual creepiness and cackle-happy lunacy with heaps and heaps of apathy for everything and everyone else (except maybe his grandchildren Morty and Summer and his daughter Beth). He's someone who gives absolutely zero fucks about leaving his entire dimension to die, and fleeing into another where his counterpart had died half a minute ago, burying him in the back yard and taking over his life, and that makes him just as crazy as the cackling lunatic the trope usually conjures.
• Robot Chicken: Whatever the scientist was who decided to resurrect a dead chicken in the title sequence for Seasons 1-5. The character in question is named Dr. Fritz Huhnmörder, though it isn't mentioned much (not at all).
• Scooby-Doo:
  • In the Scooby-Doo, Where Are You! episode "A Gaggle of Galloping Ghosts", Shaggy and Scooby play "mad scientist", whipping up a formula that would turn werewolves into pussycats. It is summarily rejected.
  • Scooby himself becomes one in The 13 Ghosts of Scooby-Doo episode "That's Monstertainment" when he and his pals are zapped into an old monster movie.
    Scooby: Rive my reation rife!
  • Velma Dinkley, the brains of the Scooby gang, becomes a mad scientist in the DVD feature Scooby-Doo! Frankencreepy, but only because she's hypnotized.
• Parodied by Sheep in the Big City's Angry Scientist (who becomes especially angry whenever anyone incorrectly refers to him as a mad scientist).
• The Simpsons: Professor Frink is a rather more amicable Mad Scientist, always apologetic when things go wrong with his inventions, and has a passion for inventing crazy things like self-aware robots that only scrub floors, auto-diallers with retractable wheels, automatic tap-dancing shoes, buildings that can sprout legs and run away from danger, and hamburger earmuffs.
  Frink: [as a radio-controlled baby-plane with his son in it crashes] Oh, dear. My wife is going to kill me.
• Skysurfer Strike Force Big Bad Cybron creates at least seven lethal cyborgs (and maybe his own daughter too, which would make eight), then wires an experimental computer brain into himself.
• South Park:
  • Dr. Mephesto, based on Marlon Brando's Dr. Moreau. The guy's greatest experiment is a FIVE-ASSED MONKEY!
    Chef: Hey, you're that crazy cracker from up on the hill.
    Mephesto: Sir, if making mutant animals spliced with humans is crazy, then-! Uh. Hmm. Oh, never mind.
  • Steve Jobs conducts an experiment called the "HumancentiPad", in which he surgically connects three people together mouth-to-anus and constantly tortures them in the process. One of the victims is Kyle, who is only in fourth grade.
• The Spectacular Spider-Man's Doctor Octopus is one of these.
• Dr. Bent, a.k.a. Overlord in Spiral Zone, a particulary nasty one for a kid's show as he created a horrible mist that causes "zones" that turn people into mindless zombies.
• In Spliced, almost all of the characters are the creations of "some crazy doctor" based on Dr. Moreau, who was arrested prior to the series by authorities disgusted with the freaks of nature he created.
• Sheldon Plankton from SpongeBob SquarePants shows signs of being this.
• Star Wars: The Clone Wars:
  • Dr. Nuvo Vindi was a former medical doctor who disappeared sometime around the Battle of Naboo before resurfacing in the employ of the Separatists. With their backing he decided to resurrect the Blue Shadow Virus, a plague that no known species is immune to and killed many people back in the day. Vindi went a step further to make it deadlier by converting it from a water-based strain to an airborne strain and having it delivered via bombs on key Republic worlds. After he's captured and his assistant droid sets off all the bombs in his hidden bunker, he's excited at the idea of one of the battle droids exiting the bunker and releasing the plague across Naboo.
  • Not of the cacklingly crazy variety, the Techno Union has been shown to dabble in inhumane experiments on sentient beings in both this show and the now Legends microseries. In the Bad Batch arc in this series, Wat Tambor has the previously thought dead Clone Trooper Echo plugged into a stasis tube to be used as an organic computer against the army he fought for, while reliving the moment of his "death" on loop for months. They also built the Organic Decimator, a small weapon that seeks out organic matter and vaporizes it, which in the unfinished reels, Tambor casually tests on a captive native as a threat to intruders. In the latter series, they kidnap male Nelvaanians and mutate them into brainwashed, cyborg supersoldiers. While the latter series is not canon, the Techno Union's activities on Nelvaan have been re-canonized.
• The first of the Superman Theatrical Cartoons, "The Mad Scientist", has one as the villain, threatening to enact vengeance on all those who laughed at him with his electrothanasia-ray.
• Baxter Stockman from Teenage Mutant Ninja Turtles.
• The Tick:
  • Chrome Dome and Brainchild.
  • El Seed and the Breadmaster may also quality for developing formulae that make plants come to life and bread explode, respectively.
  • "The Tick vs. Science" has an entire convention worth of mad scientists. To Chromedome's disgust, the attendants were all of the "weird but affable" variety.
    Chromedome: "Bah! Warm fuzzy nice nice! What good is science if no one gets hurt!?"
• Tiny Toon Adventures has Dr. Gene Splicer, the Big Bad of the episode, "Hare Raising Night", who specializes in making Mix-and-Match Critters, most notably Melvin the Monster. In addition, he is a boss in the Super Nintendo game, Buster Busts Loose, but in that game, he's only referred to as "the Mad Scientist". He is also the main villain (aside from Montana Max himself) in the Sega Genesis game, Buster's Hidden Treasure, which properly uses his full name.
• Transformers:
  • The Transformers:
    • Dr. Arkeville, though his madness is one-upped by Starscream himself in "Countdown to Extinction".
    • Wheeljack of is one. Part of his appeal was him convincing the other Autobots that his crackpot inventions were worth something. His Shattered Glass counterpart is also a mad scientist, but less the cheery genial type normal Wheeljack is, and much, much more pure distilled ranting They Called Me Mad! type of mad scientist.
  • Tarantulus of Beast Wars is, if not a mad inventor, certainly crazy enough and scientific enough and treacherous enough to qualify for Mad Scientist. This is actually a case of Character Development; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat anything he can catch". This was Adaptation Displacement—in the original toyline, he was a (still cannibalistic) ninja warrior.
  • Transformers: Animated:
    • Prometheus Black. He started out messing around with biochemical enhancements to try and beat out Professor Sumdac's robotics industry, but after a lab accident changed him into the supervillain Meltdown he went into full vengeful mad science mode. The chemical warfare specialist Oil Slick might also count, although outside the fact that he's a ninja who developed the Transformer equivalent of ebola not much is known about him.
    • Blackarachnia also has elements of this. The Allspark Almanac reveals she invented triple-changing, and her attempts to better understand her techno-organic mutation lead her to try and create another hybrid...resulting in Waspinator.
• Simon Bar Sinister, the main antagonist on Underdog, a short, nasty-looking scientist only about two feet tall, who's goal was to Take Over the World. Unlike most examples of this trope, he tended to actually listen when his henchman Cad Lackey made suggestions.
• Dr. Thadeus "Rusty" Venture in The Venture Bros., although his lack of ambitions and laziness mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb (confirmed, as part of his backstory). Mad science occurs with such frequency in the Venture Bros. universe it's seen as a valid career path and given the politically-correct name "super-science".
• Villain Protagonist Dr. Flug of Villainous works as The Dragon to the God of Evil Black Hat, creating Genetic Abominations and Mecha-Mooks for his Evil, Inc.. Most of the time he comes across as a meek Minion with an F in Evil, but very rarely displays a sadistic side rivaling that of his boss. He certainly has the "mad" part down however, as he constantly wears a paper bag over his head and has a strange obsession with airplanes (with his surname Flugslys being Icelandic for "plane crash") to the point he shoots them out of the sky with a shrink ray and keeps them in glass jars (with the passengers still inside).
• The Wacky Adventures of Ronald McDonald: The main villain of "Birthday World" is an evil scientist named Professor Thaddeus J. Pinchworm, who takes advantage of Hamburglar's guilt at not getting Ronald a birthday present by inviting the gang to a theme park as a front for using Ronald and his friends as guinea pigs for his Babe-O-Matic Ray, which he intends to use to turn everyone else on the planet into babies so he could therefore rule the world on the basis of being the only remaining adult.
• Crossing this trope with Magitek is Wakfu's Season 1 Big Bad Nox, a watchmaker who discovered that the most effective way of powering his inventions was draining the Wakfu out of living organisms. A sampling of his creations include Vampiric Literal Surveillance Bugs, ambulatory pocket watches, Killer Robots powered by the residual substance of dead souls (generated in the first place by Nox's constant killing for wakfu), animatronic replicas of his dead children...
• Wallace from Wallace & Gromit is an eccentric Absent-Minded Professor, although he usually uses his inventions for mundane things such as window-washing and humanely rounding up bunnies so they don't get in the way of the town's upcoming vegetable-growing competition. This has resulting in one case of mind-switching, Wallace turning into a Were-Rabbit, a penguin attempting to use his inventions for a jewel heist, and Wallace nearly getting killed several times. Luckily, his dog Gromit is loyal to a fault, an ace pilot, and smart enough to be able to fix things whenever they go wrong (and they do, frequently).
• Doctor Two-Brains in WordGirl.
  • Tobey has managed to invent entire armies of giant robots at the ripe old age of ten.
• Jack Spicer on Xiaolin Showdown, although he seems to specialize almost entirely in robotics.
• Professor Crazyhair from Yakkity Yak is a fairly benign and friendly example, but is still mad.

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