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Mad Scientist: Western Animation
  • Professor Farnsworth on Futurama takes this to the lengths of parody and beyond. Case in point:
    • "Even I laughed at me when I proposed the cross-species genetic analyzer, but I guess I showed myself!"
    • "Everyone's always in favour of saving Hitler's brain. But when you put it in the body of a great white shark, ooh, suddenly you've gone too far!"
    • He builds Doomsday Devices a lot. Oh, he doesn't plan to use them, he just seems to think they're cool. "I suppose I could part with one and still be feared..."
    • At one point the Planet Express crew were figuring how to enter New New York's Central Bureaucracy.
    Prof. Farnsworth: You can't just waltz into the Central Bureaucracy! It's a tangled web of red tape and regulations. I've never been, but a friend of mine went completely mad trying to find the washroom there.
    Leela: Then we'll need a guide, someone who's been there before.
    Prof. Farnsworth: Oh, I've been there. Lots of times! (Laughs maniacally)
    • His rival and former student, Professor WERNSTROM! is of the evil (or at least asshole) variation.
  • Professor Frink of The Simpsons is a rather more amicable Mad Scientist, always apologetic when things go wrong with his inventions, and a passion for inventing crazy things like self-aware robots that only scrub floors, auto-diallers with retractable wheels, automatic tap-dancing shoes, buildings that can sprout legs and run away from danger, and hamburger earmuffs.
    Frink: (as a radio controlled baby-plane with his son in it crashes) Oh dear. My wife is going to kill me.
  • The Brain of Pinky and the Brain.
  • Dr Karbunkle in Biker Mice from Mars.
  • An interesting example occurs in Adventure Time. Princess Bubblegum is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and innocently sweet, she has created two zombie plagues, created a giant immortal candy sphinx who almost destroyed the kingdom, created a screaming nutcase who threatened her with his own sword, has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts killed, and tortured the Ice King. Her "For SCIENCE!" attitude, and her devotion to the law, cause... interesting things to happen.
  • Dexter, main character of Dexter's Laboratory. And his rival Mandark.
  • Dr. Barbara "Babs" Blight on Captain Planet and the Planeteers is mad. She is insane and she is a brilliant scientist, and represents unethical scientific research and technology in the wrong hands, though sometimes, she simply causes environmental damage for the sake of doing so.
    • Some of her plans have a Freudian Excuse related to her facial scar, which can actually make her Unintentionally Sympathetic to some viewers.
      • It's all but stated that her insanity is the result of brain damage from the accident that scarred her. It's a pity that nobody in the show had healing powers.
      • Heart?
  • Star Wars: The Clone Wars: Dr. Nuvo Vindi.
  • Doctor Krieger from Archer.
  • Simon Bar Sinister from Underdog.
  • Dr. Mephesto on South Park, based on Marlon Brando's Dr. Moreau. The guy's greatest experiment is a FIVE ASSED MONKEY!
    Chef: Hey, you're that crazy cracker from up on the hill.
    Mephesto: Sir, if making mutant animals spliced with humans is crazy, then - ! Uh. Hmm. Oh, never mind.
  • A fairly large share of the Recurring Characters on Kim Possible, notably major antagonist Doctor Drakken. Even some of the good-guy characters (such as Kim's father and brothers) have mad-scientist tendencies.
  • Parodied by Sheep in the Big City's Angry Scientist (who becomes especially angry whenever anyone incorrectly refers to him as a mad scientist).
  • Professor Norton Nimnul from Chip 'n Dale Rescue Rangers.
  • Dr. Weird from Aqua Teen Hunger Force.
    Dr. Weird: Gentlemen! I have created... this thing.
    Steve: What is it?
    Dr. Weird: I don't know! Stand over here.
    Steve: What, over here — hey!
    Dr. Weird: It works! I am one can short of a six-pack! (Evil Laugh)
  • Chrome Dome and Brainchild from The Tick. El Seed and the Breadmaster may also quality for developing formulae that make plants come to life and bread explode, respectively.
    • "The Tick vs. Science" has an entire convention worth of mad scientists. To Chromedome's disgust, the attendants were all of the "weird but affable" variety.
      Chromedome: "Bah! Warm fuzzy nice nice! What good is science if no one gets hurt!?"
  • Dr. Bad Vibes from COPS
  • Megavolt from Darkwing Duck. Likewise Bushroot, who's usually ignored in this capacity, because his "mad science" is botany.
  • Dr. Sevarius from Gargoyles isn't quite mad so much as he is amoral, but he displays a touch of the theatricality that is the hallmark of the best nutty professors.
    • Then again, he is being portrayed by Tim Curry. Go figure.
  • Dr. Cinnamon J. Scudworth of Clone High certainly qualifies, even though his day job is as a high school principal.
  • The Dark Knight always seemed to be neck-deep in mad scientists on Batman: The Animated Series. Within the first five episodes of the show, he runs afoul of Man-Bat, the Scarecrow, and Poison Ivy, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who called his sanity into question.
    • Yes, killing them all will show that you are PERFECTLY sane...
      • Hey, it's not like they'll be saying otherwise.
      • Indeed, it should settle the question of his sanity quite comprehensively.
    • At Batman Beyond: Return of the Joker The Joker claims to be one. Fridge Brilliance if you think that he must have been created Joker Venom from common chemicals:
    Joker: Beneath this puckish exterior lies the mind of a genius years ahead of my time. In the weeks young Robin was under my tutelage, I used him as the subject of my greatest experiment. Using cutting-edge genetics technology which I pinched here and there, I encoded my DNA in a microchip and set it in Bird Boy's birdbrain.
  • Johnny Test's older sisters Susan and Mary are both Mad Scientist teenagers. Also their friendly enemy, Eugene, a.k.a. "Bling Bling Boy".
  • The character Vendetta on the show Making Fiends is a mad scientist, as she creates tons of fiends, which also can be considered as forms of life.
  • The title character of Invader Zim is a mad scientist himself. In fact, in a script for an incomplete Start of Darkness episode about him, Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.
    • Dib and Professor Membrane would arguably qualify as Mad Scientists. Dib perhaps more so since his inventions revolve around his all-consuming obsession to destroy ZIM, whereas his father's inventions are more geared toward helping humanity. Even the Super Toast.
      • So they're good Mad Scientists?
  • Plankton from SpongeBob SquarePants shows signs of being this.
  • The Spectacular Spider-Man's Doctor Octopus is one of these.
  • Wheeljack of Transformers Generation 1 is one. Part of his appeal was him convincing the other Autobots that his crackpot inventions were worth something.
    • His Shattered Glass counterpart is also a mad scientist, but less the cheery genial type normal Wheeljack is, and much, much more pure distilled ranting They Called Me Mad! type of mad scientist.
    • Dr. Arkeville from the G1 cartoon. Though his madness was one upped by Starscream himself in Countdown to Extinction.
  • Tarantulus of Transformers: Beast Wars is, if not a mad inventor, certainly crazy enough and scientific enough and treacherous enough to qualify for Mad Scientist.
    • This is actually a case of Character Development; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat anything he can catch". This was Adaptation Displacement—in the original toylines, he was a (still cannibalistic) ninja warrior.
  • Transformers Animated has Prometheus Black. He started out messing around with biochemical enhancements to try and beat out Professor Sumdac's robotics industry, but after a lab accident changed him into the supervillain Meltdown he went into full vengeful mad science mode. The chemical warfare specialist Oil Slick might also count, although outside the fact that he's a ninja who developed the Transformer equivalent of ebola not much is known about him.
    • Animated! Blackarachnia also has elements of this. The Allspark Almanac reveals she invented triple-changing, and her attempts to better understand her techno-organic mutation lead her to try and create another hybrid...resulting in Waspinator.
  • Dr. Thadeus "Rusty" Venture on The Venture Bros., although his lack of ambitions and laziness mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb (implied confirmed, as part of his backstory)
  • One episode of Inspector Gadget features the M.A.D. Scientist — that is, a scientist that works for M.A.D. However, he gets really, really peeved when someone calls him a mad scientist, screaming, "I'M NOT MAD!!!"
    • "I'm not MAD! I'm Dr. Focus!" (gets arrested) "Now I'm really mad!"
    • The 1999 feature film has Dr. Artemis Bradford and his daughter, Brenda, both of whom designed the title cyborg. The 2003 sequel has Baxter, who could possibly qualify...
  • Doctor Two-Brains in WordGirl.
    • Tobey has managed to invent entire armies of giant robots at the ripe old age of ten.
  • Dr. Doofenshmirtz on Phineas and Ferb is an Affably Evil Punch Clock Villain trying to conquer the Tri-State Area.
    • Phineas and Ferb themselves, actually. They do build things like city-spanning roller coasters, time machines and space ships after all, and landscapes in their backyard. Two of the sweetest, friendliest mad scientists you'll ever meet, but still.
      • With Phineastein, the Regurgitator, Professor Poofenplotz and all the members of L.O.V.E.M.U.F.F.I.N., it seems the show runs on this trope.
  • Codename: Kids Next Door has a couple, including Chester and Professor XXX-L.
  • The Tick has several: Brain Child, Professor Chromedome, mostly non-evil Julius Pendecker, and, a more benevolent (though unnerving) version, Dr. Mung-Mung, whose best-known creation is a super-strong giant made entirely of tongue.
  • Heloise from Jimmy Two-Shoes is this. Despite being a small, petite girl, she is very intelligent and sadistic as she makes inventions for Misery Inc. that would spread misery to her town and also likes to destroy things for fun. She does have a soft side though as she has feelings for Jimmy buts treats everyone else with disrespect, even her own boss.
  • Recombo from Alpha Teens on Machines.
    Recombo: My colleagues laughed and called me Recombo. They said it couldn't be done. But I shall prove them all wrong. Back home, people called me mad.
    King: Mad? I was thinking more "total wacko"!
  • Dr. Frankenollie in the 1995 Mickey Mouse short, Runaway Brain.
  • Jack Spicer on Xiaolin Showdown, although he seems to specialize almost entirely in robotics.
  • Whatever the scientist was who decided to resurrect a dead chicken in the title sequence for seasons 1-5.
  • Jonny Quest TOS:
    • Dr. Ashida in "Dragons of Ashida", who used genetic engineering on lizards to increase their size and also had a Maniacal Laugh.
    • In "Terror Island", Dr. Chu Sing Ling used a chemical to grow gigantic versions of normal creatures.
    • Dr. Phorbus in "Peril of the Reptilian"
    • Dr. Zin in general.
  • From the The Powerpuff Girls we have Mojo Jojo, complete with evil laugh. Also, he's a monkey.
    • You might even count Professor Utonium, although he's far more benign than most. Every time he creates something useful (including the Girls themselves), it's by accident. But when he tries to do something intentionally, it leads to a disaster.
  • Van Kleiss from Generator Rex.
    • Also Cesar. He single-handedly invents weaponry that can take down an entire highly-trained government base, but is a Cloud Cuckoo Lander on a good day and a totally lacks any sense of practicality or ethics on a bad day.
  • Franz Hopper from Code Lyoko is less "mad" than he is "slightly unhinged". Still, though, he manages to create a computer program that can venture into the world, take people hostage, create poisonous gas, create blizzards, and many many other things, so he definitely counts.
  • Simon Bar Sinister, the main antagonist on Underdog, a short, nasty-looking scientist only about two feet tall, who's goal was to Take Over the World. Unlike most examples of this trope, he tended to actually listen when his henchman Cad Lackey made suggestions.
  • The first Superman short, "The Mad Scientist," has one as the villain, threatening to enact vengeance on all those who laughed at him with his electrothanasia-ray.
  • Crossing this trope with Magitek is Wakfu's season one Big Bad Nox, a watchmaker who discovered that the most effective way of powering his inventions was draining the Wakfu out of living organisms. A sampling of his creations include Vampiric Literal Surveillance Bugs, ambulatory pocket watches, Killer Robots powered by the residual substance of dead souls (generated in the first place by Nox's constant killing for wakfu), animatronic replicas of his dead children...
  • Skysurfer Strike Force Big Bad, Cybron who creates at least seven (maybe his own daughter too makes eight) lethal cyborgs, then wires an experimental computer brain into himself.
  • The Justice League cartoon version of Ultra-Humanite has all the characteristics of the traditional, cultured Mad Scientist. With an emphasis on 'cultured'.
  • Wallace from Wallace & Gromit is an eccentric, absent-minded inventor, although he usually uses his inventions for mundane things such as window-washing and humanely rounding up bunnies so they don't get in the way of the town's upcoming vegetable-growing competition. This has resulting in one case of mind-switching, Wallace turning into a Were-Rabbit, a penguin attempting to use his inventions for a jewel heist, and Wallace nearly getting killed several times. Luckily, his dog Gromit is loyal to a fault, an ace pilot, and smart enough to be able to fix things whenever they go wrong (and they do, frequently).
  • Professor Crazyhair from Yakkity Yak is a fairly benign and friendly example, but is still mad.
  • League of Super Evils Doktor Frogg.
  • The Alvin Show has Clyde Crashcup, who tries (but always fails) to "invent" something.
  • Grojband has Kin, as he's often the most morally dubious of the band given his creepy obsession with science.
  • Rick Sanchez from Rick and Morty is as mad as they come.
  • Baxter Stockman from Teenage Mutant Ninja Turtles.
  • Dr. Mindbender from G.I. Joe.
  • Tiny Toon Adventures has Dr. Gene Splicer, the Big Bad of the episode Hare Raising Night. In addition, he is a boss in the Super Nintendo game Buster Busts Loose, but in that game, he's only referred to as "the Mad Scientist". He is also the main villain (aside from Montana Max himself) in the Sega Genesis game, Buster's Hidden Treasure, which properly uses his full name.
  • Nathan from The Garfield Show.

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