Roy Greenhilt has his snarkiness being his primary character flaw — according to the beings of pure law and good that judge him in the afterlife, anyway. Since he is Lawful Good, that's a flaw.
Among the supporting roles, Vaarsuvius plays this role often.
Crystal: Arrgh! You little twit, I'm gonna kill you! Belkar: Yeah, and I'm going to drop a house on you and sing about how I represent the Lollipop Guild. C'mon, let's keep our threats realistic, shall we?
Redcloak: I'm on my way to finish zombifying the monsters we killed up in the tower. MitD: Yeah, I can help with that. Redcloak: Really? So, I guess those three boxes of mallomars you finished off somehow earned you enough XP to gain 5 levels in cleric overnight. MitD: Well, they were especially chewy.... Redcloak: Then unless you are volunteering your services as raw materials, I don't think you are going to be much help.
Early in the comic's run, Faye and Martin got their new apartment because the landlady liked their snarkiness.
Kadeen of Knights Errant gets an honorable mention for snarking while suffering from a massive chest wound.
Nearly all the cast of Something Positive, but Davan is King Snark. Also many people in another of the author's comics, Super Stupor. Come to think of it, perhaps every character R. K. Milholland creates.
And thus, probably Milholland himself, as well.
ADVENTURERS! has one in each camp: Ardam for the heroes and Argent for the villains. Though Ardam is usually more "exasperated" than "deadpan".
Jason in Multiplex. Funnily enough, he is often confused for an Author Avatar, which the author denies... to some extent.
Most of the cast of Lackadaisy Cats indulges in some snark, but Zib almost exists to offer his sarcastic take on matters.
Rayne of Least I Could Do goes so far over the top with the Idiot Hero and Handsome Lech routines that most of the rest of the cast are divided into those who can use deadpan snarking to survive his bombastic ways (Issa and Noel), and those who turn into his punching bags (Jon and Mick). Noel is probably the best example.
Any character in Antihero for Hire who isn't a) Doctor Nefarious b) ice-powered guy still looking for a name c) Baron Diamond. And they have their moments.
Half the regular [non-superhero] cast in Head Trip, Lilian especially, plus Chemokid.
A vast majority of the cast of 8-Bit Theater. Most notable are Sarda, Black Mage, Thief, and White Mage.
Every main and supporting character in both Michael Poe's Errant Story have their moments of this, but the males seem especially prone to it. Jon and Ellis probably have a Snark/Strip ratio of 2:1.
Green in The Law of Purple occasionally pulls a Deadpan Snarker moment, as does his brother Blue.
Yeager: Contrary to... most of my dating history, not every woman who's interested in me is a flesh-craving abomination. Artax: Really? Have you been seeing someone we don't know about?
Artax: She Who Must Not Be Named has taken That Which Man Was Not Meant To Know! Nodwick: Did she say where She Who went? Artax: To The Lands Which Know No Name! Nodwick: Uh-huh... let me know if we find any proper nouns in all this mess.
Disputed in Family Matters by Francis, who thinks Brent has become more of a Jerk with a Heart of Gold. Francis also suggests that the new deadpan snarker be Max Powers.
McCain from Bittersweet Candy Bowl has this down to an art. Lucy can be pretty good at this too.
Bert and Darby from TRU-Life Adventures are the most consistently snarky among the toy store staff, but almost everyone working there gets a moment. It must be a survival technique for dealing with the customers.
So, so, so many examples from Homestuck. Just within the main characters, Dave, Rose, and occasionally John all qualify, and beyond that, practically half the cast qualifies.
All of the characters in Out There, but mostly Sherry, Clayton, and James.
Erfworld gives us Prince Tramennis and, to a lesser extent, Foolamancer Jack Snipe.
Harold Eastwood (On Virus smoking in his intro page): You mean it was a lame attempt to look badass. Syrus "The Virus" Zuviel: Did it work? Eastwood: No, you just looked like a regular ass. Virus: Ha. And indeed, ha. Don't quit your day job Harry.
Most of the main cast of Rumors of War, and a good chunk of the periphery characters are snarky — possibly to the point of creating a veritable World of Snark.
