- Voiced by: Bret Iwan
The main character is none other than Disney's own mascot, based on his early appearances as a mischievous mouse. His attempts to use Yen Sid's magical paintbrush accidentally led to him creating the game's main antagonist, the Shadow Blot, and causing the Thinner Disaster which ruined the Wasteland.
- Anti-Hero: And in an old concept, it changes his appearance; Type III as Wastelander, Type IV-V as Scrapper.
- Art Attacker: In the game, he uses paint and thinner as weapons.
- The Atoner: He created the Shadow Blot by mistake, so he has to make amends by defeating the Blot and helping out everyone in Wasteland.
- Badass Adorable: He's very likable and quite heroic.
- Cain and Abel: The Abel to Oswald's Cain.
- Dark Is Not Evil: Even with three Paint Guardians, some paint will evaporate off of Mickey (and with three Thinner Guardians, it's constantly streaming off of him). Folks will even note that Mickey reminds them of the Blot like this — but even with this, he can still be just as heroic as the player wants.
- Determinator: He doesn't let anything sway him.
- The Hero: As the main protagonist, it is his duty to defeat the Shadow Blot.
- Heroic Sacrifice: When the real Shadow Blot is released, Mickey willingly gives up his heart to save Oswald and Gus from its clutches.
- Improbable Weapon User: He wields Yen Sid's magical paintbrush, shooting Paint and Thinner at enemies and the environment alike.
- Jerkass: He can be this if you choose to defeat certain bosses with thinner rather than redeem them with paint and if you neglect to resolve important quests.
- Karma Meter: Subverted. There's a meter that shows whether you prefer paint or thinner, but not how you're using them.
- Mike Nelson, Destroyer of Worlds: He did not create the Shadow Blot on purpose.
- Nice Job Breaking It, Hero!: If he hadn't messed around with Yen Sid's stuff, the Shadow Blot wouldn't exist.
- Not So Different: From Oswald.
- Older Than They Look: The game goes with the interpretation that all cartoon characters are as old as their first cartoon, and given that Mickey's first cartoon was made in 1928.
- Sociopathic Hero: If you play towards the darker and edgier side of the morality system.
- Voiced by: Frank Welker
Originally created by Walt Disney before Mickey Mouse, Oswald was the ruler of the Wasteland, but since the arrival of the Blot, he is now fighting against it as leader of La Résistance.
- The Atoner: After he realizes that Mickey isn't such a bad guy, he becomes nicer to him and helps him fight the Shadow Blot.
- Badass Adorable: Probably.
- Cain and Abel: The Cain to Mickey's Abel.
- Chair Reveal: When first encountered, he is in a revolving chair.
- Chaste Toons: Averted. In the interim, Oswald managed to wind up with 420 Bunny Children. "Lucky" rabbit, indeed.
- Deadpan Snarker: His years of being forgotten has left him bitter and cynical.
- Deuteragonist: Being Mickey's metaphysical older brother, it's kind of inevitable. Up to Eleven in the sequel, where he's the other player character.
- Forgotten Childhood Friend / Long-Lost Relative: And not very happy about it.
- Heli-Critter: In the trailer for Epic Mickey 2, he flies around rotating his ears like helicopter blades.
- In-game, he uses this to glide across long gaps.
- Jerkass: the insults and mockeries he throws at Mickey.
- Jerk with a Heart of Gold: At the end of the game, he gives back Mickey's heart to him. It also counts as a Crowning Moment of Heartwarming.
- Motor Mouth: He talks fast.
- The Napoleon: If you don't count the ears, he's much smaller than Mickey is.
- Nice Job Breaking It, Hero!: Though not as obvious as Mickey's, near the climax, Oswald accidentally breaks the seal on the real Shadow Blot.
- Nostalgia Level: Before meeting Oswald for the first time, the player is challenged to three stages based on Oswald's cartoon short films.
- Not So Different: From his half-brother, Mickey. Or the Shadow Blot, for that matter.
- Older Than They Look: His first cartoon was made in the 1920's, so it isn't a surprise that by the time of this game, he would technically be in his 80's.
- The Resenter: And he makes no secret of it.Mickey: "I get that he resents me, but—"Oswald: "Gee, ya THINK?"
- The Rival / Unknown Rival: Created before Mickey, Oswald was always jealous of his "half-brother" for stealing what he felt should have have been his life.
- Royals Who Actually Do Something: The former king of Wasteland, now leader of La Résistance.
- Sanity Slippage: Yeah...
- Shock and Awe: His remote control in the second game.
- Small Name, Big Ego: Ohhhhhhhhhhh yes. Just take a look at all of the monuments in Wasteland with Oswald's likeness. A particularly amusing example is the "OsTown" sign... it's just the word "Toontown" with the first two letters smashed and the 'N' turned on its side.
- Tsundere: Type A to Mickey.
- Voiced by: Bob Joles (First Game Only); Cary Elwes
Mickey's first companion, Gus is one of the Gremlins fighting against the Shadow Blot, and providing commentary and exposition for Mickey.
- Captain Obvious: Frequently instructs you to do things that you've likely already figured out yourself.
- Deadpan Snarker: Not above making sarcastic remarks.
- Exposition Fairy: He explains to Mickey about the Thinner Disaster that Wasteland suffered as well as how to fight enemies.
- La Résistance: Leads the other Gremlins into fighting back against the minions of the Blot and the Mad Doctor.
- Plucky Comic Relief: Pretty much serves to make Mickey look serious and down-to-earth in comparison.
- Percussive Maintenance: Like his brethren, he can fix up a machine just by whacking the hell out of it.
- Sidekick: He helps Mickey.
- Voiced by Audrey Wasilewski
Oswald's love interest.
- And I Must Scream: See Taken for Granite.
- Going Commando: The graphic novel features some shots of her skirt that make it clear that she isn't wearing panties, in contrast to actually having them in the game.
- Explosive Breeder: 420 children.
- Interspecies Romance: A cat who is the love interest of a rabbit.
- Nice Hat: She wears a tiny hat with a flower.
- Taken for Granite: What happened to her after she and Oswald stuffed the real Shadow Blot in a giant bottle. In the end, it's reversed.
Originally the "Phantom Blot" from the Mickey Mouse Comic Universe, the Shadow Blot is the game's main antagonist, a creation of Paint and Thinner that threatens the Cartoon Wasteland.
- Adaptation Name Change: Is actually called the Phantom Blot in the graphic novel.
- Blob Monster: He's made of an inky black slime.
- Dark Is Not Evil: If you redeem the smaller Shadow Blot, he becomes this.
- Eldritch Abomination: A giant creature made of paint and thinner.
- Evil Overlooker: Concept art depicts him looking menacingly over Mickey.
- Fighting a Shadow: The boss battle atop Mickeyjunk Mountain. It is actually just another Blotling, merely an unusually large droplet of the real thing leaking out of the bottle!
- Greater-Scope Villain: The REAL Shadow Blot.
- Not So Different: From Oswald.
- One-Winged Angel: Becomes enormous in the final battle.
- Sealed Evil in a Can: Oswald and Ortensia sealed the real Shadow Blot inside the same bottle of Thinner that Mickey dropped into the Wasteland.
- Slasher Smile: Just look at the picture!!!
From the 1933 short where he kidnapped Mickey's dog Pluto, The Mad Doctor stands alongside the Shadow Blot as the main antagonist in the game. He is the Big Bad of the sequel all on his own, taking on a much more comedic role than in the original.
- Card-Carrying Villain: A guy who insists on people calling him "the Mad Doctor" probably had it coming, but he gets it big time in Epic Mickey 2: The Power of Two: he creates a TV show named The Mad Doctor's Wonderful World of Evil, his recurring line in his song Mad Doctor's Plan is: "Who's the maddest Mad Doctor of all ? Wonderfully evil me !"… and all this is nothing. But his big, overcomplicated Evil Plan is not about seizing power or bringing about the end of the world: his self-admitted goal is "to become the greatest villain of all times".
- Chronic Backstabbing Disorder: He suffers from this really badly. First he backstabbed Oswald when he started to lose the Blot War, and then he plans to backstab the Blot the moment he gets Mickey's heart. And he's at it again in the sequel. Guy just doesn't quit.
- Evil Laugh: It is even lampshaded in a cutscene when Gus asks Oswald exactly which Evil Laugh it was.
- Falsely Reformed Villain: In Epic Mickey 2, he got back in Oswald's favor by claiming that he has reformed and now wants to save Wasteland from some appearent unknown threat. It shouldn't be too difficult to figuring it out if he's truely sincere or not; Ortensia and Mickey distrust him from the beginning.
- Heel–Face Turn: Turns good for real if you beat him with paint in Epic Mickey 2.
- Insistent Terminology: During his boss fight, he becomes enraged that Gus continues calling him "Doc" instead of "The Mad Doctor".
- Large Ham: In the sequel, befitting a character who communicates almost entirely in over-the top Villain Songs, even for 30-second transmitted messages. It even applies when he's not singing.
- Mad Scientist: He's responsible for creating the Beetleworx, among other things. And he flies around in a hovering snowglobe.
- Manipulative Bastard: He pretends to have reformed in the second game, though he can be redeemed for real if you choose to defeat him with paint instead of thinner.
- Morally Ambiguous Doctorate: He is a doctor who is evil.
- No Name Given: While he was named "Dr. XXX" in his original short, here he is simply "The Mad Doctor".
- Older Than They Look: A given considering that he debuted in the 1930s and the first game came out in 2010.
- Robotic Reveal: When defeated at Lonesome Manor, his paint partially peels away to reveal that he himself is a Beetleworx, knowing that animatronics would be the only thing that would survive the Shadow Blot's inevitable draining of Wasteland.
- Villain Song: Speaks almost entirely in song in the sequel until the final boss battle."(starting to sing) One more step and your friends are... (stops singing) history".
The smiling, golden-faced Clock Tower from the "It's A Small World" ride serves as the first boss. He'll try to flatten Mickey with his huge armored fists and arms.
- And I Must Scream: If you defeat him instead of redeem him.
- Ax-Crazy: Attacks Mickey on sight for no known reason.
- Background Boss: For most of the battle. If you're redeeming him, you'll interact with his face.
- Clockwork Creature: Of course.
- Giant Hands of Doom: He tries to crush Mickey with his hands.
- Ludicrous Gibs: When you completely thin the Clock Tower's hands and arms, thinner sprays from the stumps. Eeeewww.
- Slasher Smile: In his "crazed" mode. YMMV on whether or not it's creepier than his normal expression.
The PetesThe chief authority in Mean Street, Pete has several counterparts in other areas of Wasteland, including Small Pete near Gremlin Village, Petetronic in Tomorrowland, and Pete Pan in Pirates of the Wasteland; all of them know each other. He may become nicer (or not) depending on the player's actions.
- Brought Down to Normal: Before Mickey makes it to Ventureland, the Animatronic Captain Hook captured Tinker Bell, leaving Pete Pan without his powers of Flight.
- Child Hater: Peg-leg Pete offers pins to Mickey to so Pete can wrangle up Oswald's meddlesome children and jail them in the sheriff's office.
- Tennis Boss: Petetronic battles Mickey by throwing his the disc on his back like a frisbee, allowing Mickey to send it flying back at him with the magic Brush.
- Wholesome Crossdresser: Small Pete has a blonde wig and wears a dress with no mark on his character; as a Pete, he hurts his reputation on his own.
- Voiced by: Dominic Keating
- Anti-Villain: Some fans make a case for this.
- Ascended Extra: Only appears for two quests in the first game but his actions become a major plot point in the second.
- Brainwashed and Crazy: After his battle, the Mad Doctor brainwashes him and he is promptly locked up in jail.
- Deadpan Snarker: Possibly the snarkiest character in the series.Gremlin Prescott: (to Mickey): "Well, well. Now look who's decided to grace us with his presence."
- Face–Heel Turn: Turns evil in the second game.
- The Napoleon: Heck, the pin you get in the Thinner version of his boss battle is called the Napoleon Complex Pin.
- Percussive Maintenance: Comes with being a gremlin, apparently.
The Animatronics (Goofy, Donald Duck, and Daisy)Mickey's classic comrades appear as animatronic recreations made by the Mad Doctor so Oswald could have his own close friends. They're located in various hubs around Wasteland, who have been attacked and disassembled by the Mad Doctor's Beetleworx army.
- Adapted Out: Animatronic Daisy is nowhere to be seen in the graphic novel, while Animatronic Goofy and Animatronic Donald only get briefly mentioned as well as a one-panel cameo.
- Brain in a Jar: When first encountered, each of them is a disembodied head in a jar. Some of the games' quests involve finding their body parts so that they can be put back together.
- Dark Is Not Evil: Okay, they're creepy looking, but they're nice animatronic toons.
- Robot Buddy: They are technically robots and are just as chummy to Mickey as their real counterparts.
The Bunny ChildrenThe many, many infant children of Oswald and Ortensia that run around the Wasteland causing trouble.
- Zerg Rush: They always run towards Mickey.