- Cast Incest: Juliette Lewis plays David's girlfriend in the second episode. She and David's actor Johnny Galecki played siblings in National Lampoon's Christmas Vacation.
- Development Gag: At one point in the first episode, Becky tells Darlene that she's "the obvious choice to take over for [Roseanne]", in regards to helping run the household. The initial idea for what became The Conners was in fact a spinoff centered around Darlene.
- Disowned Adaptation: Roseanne Barr was predictably pretty upset with the show. What rather fewer people saw coming was her going so far as to get her rabbi to make a statement condemning the show for being unnecessarily grim in killing her off.
- McLeaned: Roseanne is killed offscreen due to an opioid overdose.
- The Other Darrin: Xosha Roquemore played DJ's wife Geena in the season 10 revival of Roseanne. She's being replaced by Maya Lynne Robinson for The Conners.
- What Could Have Been: When talk about a potential spinoff of Roseanne first began surfacing, it was reported that ABC was considering centering the show around Sara Gilbert's Darlene character, possibly even naming the show Darlene. In the end, it was decided to focus on the entire Conner clan.
Trivia / The Conners