Her siblings are Jonathan and Melissa Gilbert.
Openly gay, she has been in relationships with producer Ali Adler and musician Linda Perry. Sara has three children: two with Adler and one with Perry.
Film Roles
- Poison Ivy as Sylvie Cooper
- Desert Blue as Sandy
- Light It Up as Lynn Sabatini
- The Big Tease as Gretle Dickens
- High Fidelity as Annaugh Moss
- Riding in Cars with Boys as Tina Barr
- Laws of Attraction as Gary Gadget's Assistant (Cameo)
Television Roles
- Roseanne as Darlene Conner-Healy
- The Conners as Darlene Conner-Healy
- The Simpsons as Laura Powers (1 episode)
- Saturday Night Live As Herself/Host (1 episode)
- Welcome To New York as Amy Manning
- Rugrats as Cindy (1 episode)
- 24 as Paula Schaeffer (recurring)
- Will & Grace as Cheryl (1 episode)
- Strong Medicine as Charlayne (1 episode)
- ER as Dr. Jane Figler (recurring)
- The Clinic as Mrs. Jennings (1 episode)
- Twins Mrs. Mitchee
- The Class (2006) as Fern Velch (recurring)
- Private Practice as Kelly (1 episode)
- The Big Bang Theory as Leslie Winkle (recurring)
- Law & Order: Special Victims Unit as Caitlyn Ryan (1 episode)
- Hawthorne as Malia Price (3 episodes)
- Grey's Anatomy as Kim (1 episode)
- The Talk As Herself (2010-2019, also creator and producer)
- Supergirl (2015) as Sara Gilbert (1 episode)
- Bad Teacher as Irene Dudek
- Jane the Virgin as Herself (1 episode)
- Living Biblically as Cheryl
- Weird City as Jathryn (1 episode)
- Atypical as Prof. Judd (recurring)
- Equal as JM from Cleveland
