YMMV / Destroy All Humans!

• Aluminum Christmas Trees: While Majestic seems made up by the programmers based on The Men in Black, there actually was (allegedly) such an organization. Majestic-12 was the subject of many UFO-related conspiracy theories, the belief being that it was founded by U.S. President Harry S. Truman in the late-40's and was the government agency that investigated the Roswell UFO incident.
• Genius Bonus: A few of the rural pedestrians refer to a Dr. Kinsey in their more provocative thoughts. Alfred Kinsey was a sexologist whose works provoked significant controversy in the 1950s, but is now widely considered a major influence in the study of human sexuality.
• Goddamned Bats: The soldiers in the first game can easily become this. Their rifles aren't as strong as the shotguns used by the police force and anything Majestic agents use, but a single shot can still cause a lot of damage to Crypto, they soak up more damage than most human enemies, and they're deployed in groups. What makes it worse is the fact that Capitol City replaces the police force with army soldiers and Majestic agents, making it near impossible to harvest DNA within the city.
• It Was His Sled: The fact that Silhouette is actually a woman.
• Scrappy Mechanic: Crypto's jetpack. What seems like a useful feature (Crypto's only way to travel distances and to reach platforms) is left underwhelming by the fact that it only lasts for around three seconds before the battery level drops, causing the jetpack to stutter. This can cause Crypto to lose health if he lands on a high structure without button mashing, and in several situations it is difficult to maneuver due to sentry guns, EMP mines and S-A-M launchers. Even worse is the fact that it cannot be upgraded. Thankfully, the jetpack does not have a charge level in the next games and is able to be upgraded.
• Tear Jerker: The scene where Crypto stumbles across the dissected cadaver of Crypto-136 can be surprisingly poignant, especially as it's the first time he's seen getting upset about anything. Made even more so by the fact that when seeing this, he asks how such "intelligent creatures" could do something so disgusting. Keep in mind up to this point in the game, he's referred to humans as filthy or stupid hairless monkeys. This isn't Crypto being his usual rude and aggressive self. This is what he genuinely thought of humanity before witnessing that. Even Pox is unusually subdued in the dialogue afterwards.
• That One Level: A lot of missions can end up in this state, especially if Crypto doesn't have essential upgrades or Gene Blends.
  • "Foreign Correspondent." As if the first part being a Stealth-Based Mission requiring you to sneak past an assload of Majestic agents (who can forcibly remove your Holobob disguise) wasn't frustrating enough, the second part requires you to escort a fragile human NPC all the way back to your saucer. One whose AI is not smart enough to stop him from crossing the street in front of traffic. Thankfully, the mission was toned down in the remake, with the stealth component of the first half being made optional and the escort section being made much shorter (combined with the NPC now being Friendly Fireproof).
  • "Duck and Cover!" If being an Escort Mission wasn't annoying enough, you're escorting a nuclear bomb. You have to defend it against waves of gun-toting soldier and Majestic agents who don't seem to realize that shooting at it is a bad idea. Not only that, but the driver only stops when Crypto is standing in-front of it, meaning that he'll just drive right into obstacles, including frustratingly inconspicuous landmines, unless Crypto destroys or moves the obstacles out of the way. And if you thought this mission was bad in the original, it's become downright ruthless in the remake. The bomb truck moves more quickly, giving you less time to remove hazards from its path, said hazards destroy it extremely quickly, and all the while, soldiers will frequently spawn in groups and often ignore Crypto entirely to focus on the truck, to say nothing of the ones with bazookas that hide off the side of the road to take potshots at the truck. And the checkpoint system does not work in your favor here, since the truck's health is saved at each checkpoint.
  • "The Lone Gunman" can be extremely tedious due to the swarms of Majestic agents and power-suit mech machines you have to fight off, all while reaching President Huffman's booth. Not to mention how you'll likely need the final Psychokinesis for an extended Holobob capacity, as well as bypassing the Majestic agents who can see past your disguise.
• That One Sidequest:
  • "The Great Cow Race". What sounds like an easy mission that one could breeze through in under a minute ("just beat the cows to the finish line; it should be easy using your jetpack") turns out to be a strong contender for the most frustrating mission in the entire game. Aside from the fact that the game's jetpack is notoriously terrible and unable to be upgraded, there's also the fact that the mission causes tons of anti-air turrets to spawn, which means that using your jetpack at all during the mission guarantees that you'll quickly have to endure a hailstorm of bullets that can turn you into alien mince meat unless you get back to the ground and stay there. The mission is damn near impossible to do without enabling the "Bulletproof Crypto" and "Ammo-A-Plenty" cheat codes.
  • Finding all the probes. Made worse by the fact that the game gives absolutely no hints whatsoever for finding them. This is mitigated in the remake, where drones are easier to spot due to the areas they're in being easier to see and due to the updated map.
• They Wasted a Perfectly Good Character:
  • Silhouette gets barely any screen time compared to later antagonists (in fact, Crypto only meets Silhouette during the very last mission), making the twist involving her have much less impact. What's more, Silhouette is a highly credible boss fight who can take on Crypto in unarmed combat, and her ridiculously sexist thoughts when scanned manage to cross the line from offensive back to funny.
  • A location example: Union Town. The map's gritty industrial atmosphere offers a noticeable contrast with the Down on the Farm feel of Rockwell and the bright Stepford Suburbia of Santa Modesta. One could imagine dealing with Greaser Delinquents, The Mafia, Hardboiled Detectives, actual communists, and more. And yet, only two missions took place in Union Town, one of which involved recovering your gear and your saucer after getting shot down and the other of which was the Boss Battle against Armquist, both of which took place in areas of the map largely separate from the rest.
• Unintentionally Unsympathetic: Crypto when he discovers Crypto-136's corpse. He goes on a spiel about how awful humans are for doing it, and it's played as tragic. It's kind of hard to sympathize with him since he had no problems mutilating humans and blowing their homes to kingdom come.
• Woolseyism: The Japanese dub, somewhat, in terms of humor. Since most of the humor of the game is based mainly on American clichés of the sci-fi genre, especially from the Alien Invasion genre, and most of the jokes are very obscure for non-American players, the Japanese version went to almost the Gag Dub territory. While the plot is still the same, the characterizations of almost everyone are somewhat different from the original English version. This is more notable with Crypto, since while in the English version he had a deep voice, in the Japanese dub he sounds like Bugs Bunny mixed with a Japanese Delinquent. This is even more hilarious if you take into account Crypto is in fact voiced the same voice actor who officially dubs Bugs in Japan. You can see a clip of that dub here at 4:28.
  • As an additional note, Crypto's Berserk Button about being called green is being replaced in the Japanese dub about being called a Martian instead.