In general, voice actresses are typically cast as male pups (notably Cree Summer, Kath Soucie, Grey DeLisle, and E.G. Daily). This makes the irony of Patches' two male friends who berate him for being "girly" all the better.
Yvette Nicole Brown and Alanna Ubach voice Sparky and Mr. Nut Nut.
Enforced Method Acting: Not by the actors, but by the studio. The voice cars of the Pound Puppies had their voice equipment pitched up when voicing the Kennel Kittens.
Quietly Cancelled: After season three, the series went on indefinite hiatus without any announcement of its fate. It's presumed that poor sales of the coinciding toy line resulted in Hasbro deciding to quietly wind it down.
Talking to Himself: The Pound Puppies' voice actors also provide the voices of their Kennel Kitten counterparts. Additionally, Alanna Ubach and John DiMaggio frequently voice pups, dogs, cats, and humans they cross paths with.