- Author Existence Failure: Hal Smith did not reprise his role as Gyro Gearloose from DuckTales (1987) due to the game being developed after his death. As a result, Gyro is instead voiced by Corey Burton.
- In Memoriam: The game was dedicated to the memory of Carl Barks, who died two months before the game's initial release.
- The Other Darrin: In addition to replacing the late Hal Smith as the voice of Gyro Gearloose, the game also has Corey Burton replace Rob Paulsen as the voice of Gladstone Gander and Christopher Lloyd as Merlock.
- Role Reprise: Aside from Tony Anselmo, Tress MacNeille, and Russi Taylor obviously reprising their roles as Donald Duck, Daisy Duck, and Donald's nephews Huey, Dewey, and Louie, June Foray reprises her DuckTales (1987) role as Magica De Spell and the Beagle Boy faced in the Duckburg boss fight is voiced by Frank Welker using his Bigtime Beagle voice.
- Talking to Himself: Gyro, Gladstone, and Merlock are all played by Corey Burton.
Trivia / Donald Duck: Goin' Qu@ckers