The Godfather: The ending of the film with the door being closed on Kay as she stares at Michael is a homage famous ending of the door closing on Ethan as he wanders out into the wilderness. Both signaling them as worlds they can't be a part of.
Kill Bill: The Bride is shown framed in the door of the chapel mirroring the famous final shot of film. Also, after the battle with Elle, the door slams shut after The Bride leaves, again, also like the final shot of the film.
The Lone Ranger: The attack on the ranch by fake Comanches is identical to the attack on the Edwards ranch including the birds being flushed as a warning.
Mean Streets: Charlie, Michael and Tony go see the movie in the theater at one point.
Once Upon a Time in the West: The massacre of the McBain family by Frank's men is homage to the Comanche attack on the Edwards farmstead. The ending of where Harmonica and Cheyenne move on rather than join modern society also echoes the famous ending of the film
The film was a favorite of George Lucas and so has been referenced throughout the Star Wars films:
A New Hope: The scene of Luke returning to his destroyed Tatooine farmstead and the charred remains of his aunt and uncle courtesy of the Storm Troopers is a mirror of Ethan discovering the aftermath of the Comanche attack on his family's farmstead.
Attack of the Clones: The brief montage of Anakin going out to look for his missing mother, who had been kidnapped by Tusken Raiders, and his massacre of the Tuskan Raider village is another Shout-Out to the film. Some of Tatooine's landscape is even designed to look like Monument Valley.
Rogue One: The opening scenes of the film mirrors scenes from the film: the piggy-tailed character of character Jyn is hidden by her parents when their homestead is attacked by Imperials in the same way Debbie is saved by her parents when they are attacked by the Comanches.
Taxi Driver: Travis Bickle is considered to be a then-modernized urban update of Ethan Edwards, per his creators Paul Schrader and Martin Scorsese. One of the plotlines of the film with Travis wanting to rescue Iris, a child prostitute, from her pimp, "Sport", was regarded to be a transplanting the basic premise of The Searchers from the 1870s Texas to 1970s New York City. They also gave Travis cowboy boots and "Sport" some Indian feathers on his hat to further link the two films.
Schrader would later write and direct Hardcore, another modernized urban update, with deeply religious Michigan businessman Jake Van Dorn traveling to California to find his runaway daughter, who's working as a porn actress.
The title of Buddy Holly's song "That'll Be The Day" comes from Wayne's repeated usage of the line the film. Holly was from the Texas Panhandle (Lubbock specifically), the same region where the story takes place, which probably gave him extra interest in the film.
British band, The Searchers, take their name from the film.
