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Portrayed by: Hilary DuffThe main character. The show revolves around the lives of her and her friends. She is a shy girl and a little clumsy. She dreams to fit in and be popular. She has an animated inner voice that breaks the fourth wall to reveal her thoughts and feelings. As of the movie, she makes peace with her enemy, Kate, saves a singer's career, and becomes an Official Couple with Gordo.
Portrayed by: LalaineLizzie's best female friend. She is arguably the most self conscious character in the show. She has a hard time dealing with being a teenager and growing up. Near the end of the series she goes to Mexico with her family.
David "Gordo" Gordon
Portrayed by: Adam LambergLizzie's best male friend, and a very loyal one at that, as seen in the movie. They were friends since a very young age. Gordo is a straight A student, being the smartest and practical kid on the show. As of the movie he is in an Official Couple with Lizzie.
Portrayed by: Jake ThomasLizzie's younger brother. He can be annoying and very clever. Regardless, he does care about Lizzie and his relationship with her is no different then any other sibling relationship.
Portrayed by: Hallie ToddLizzie's mother. Always gives advice to Lizzie and is sometimes strict to her children when needed.
Portrayed by: Robert CarradineLizzie's father. Like most sitcom dads, he isn't the brightest, but he's a nice enough guy.
Portrayed by: Ashlie BrillaultThe Alpha Bitch and an old friend of Lizzie's. They were the best of friends but had a falling out shortly before the series. She becomes the main antagonist of most of the series but as of the movie, she has a Heel-Face Turn and befriends Lizzie again.
Portrayed by: Clayton SnyderA handsome and popular yet dimwitted boy in Lizzie's school. Almost all the girls want him and he's pretty nice (except in the first season).
Larry TudgemanThe least popular boy at Lizzie's school. Despite this he is pretty nice to people, and gets a friendly enough treatment from Lizzie. He had a crush on Lizzie, but when she decides not to return the feelings, he was pretty understanding.
Claire MillerKate's lackey and current friend (until the movie).
Portrayed by: Yani GellmanA handsome Italian pop star that Lizzie meets in the movie. He befriends her during her trip to Rome. He offers to have him sing in his ex girlfriend, Isabella's place at a concert. Turns out he's using Lizzie's resemblance to her to frame Isabella from lip synching to avoid breach of contract.
Isabella ParigiPaolo's ex girlfriend who bares a heavy resemblance to Lizzie, except for the different hair color. Paolo befriends Lizzie because of this, turns out she's a target of Paolo's plan to avoid being sued, by framing Isabella for lip synching.
Portrayed by: Alex BorsteinThe princial of the high school Lizzie and Gordo will be attending, as well as the chaperone of the class.