- Acting for Two: In The Movie, Isabella Parigi is portrayed by Hilary Duff, but some sources say Haylie Duff (Hilary's sister) provided the singing voice.
- Actor Allusion: One is made with David and Robert Carradine in the episode where Gordo and Matt make a kung fu movie.
- Actor-Shared Background: Adam Lamberg is Jewish like his character.
- Dawson Casting:
Animated Lizzie: Wow, Miranda's officially in love with acting. Maybe when she's thirty years old, she can play a teenager on Dawson's Creek.
- 17-year old Adam Lamberg as Gordo; because he hit puberty late, he is actually able to pass as a 12-year old pretty convincingly in the pilot, and he managed to remain shorter than Lizzie and Miranda all the way through to the end.
- 18-year old Kyle Downes as middle schooler Larry Tudgeman. Made more Egregious by the fact that, in the previous series he was in (the Retroactive Recognition-palooza Higher Ground), he was cast as a troubled high schooler.
- Also comes up in Conversational Troping when Miranda acts in a school play:
- Defictionalization: In one episode, Lizzie was inspired to spend more time with her mother after reading a novel titled The Orchids and Gumbo Poker Club for a school assignment. Disney later published an actual novel with that title, with notes from Lizzie included in the margins.
- Fake Nationality:
- The Merch: Fortune magazine estimated in 2003 that Lizzie McGuire merchandise had earned the Walt Disney Co. nearly $100 million! That's from Radio Disney's big CD promotion, books based on the episodes being sold, mystery books starring Lizzie (much in the same vein as the Mary-Kate and Ashley Olsen mystery books), Tokyo POP manga adaptations, bed sheets, Barbie dolls, board games, and The Movie.
- Reality Subtext: Aaron Carter guest stars As Himself and shares a kiss with Lizzie under the mistletoe. Carter dated Hilary Duff for a while.
- Technology Marches On:
- In an earlier episode, Matt and Lanny try to raise the money to buy ninety-dollar walkie-talkies. A floppy disk and a VHS tape make appearances in the same episode.
- Throughout the series, Lizzie, Miranda, and Gordo have landlines in their bedrooms rather than cell phones.
- In Rumors, Lizzie and Miranda are chatting on a fake ICQ client while using Windows 98!
- In "Lizzie and Kate's Big Adventure", Lizzie and Kate have to go to an Internet café in order to get DSL.
- What Could Have Been:
- They seemed to be building up to a romance between Larry and Miranda before the latter left the show. The storyline where he hooks up with a minor recurring character was most likely originally for her.
- There were plans to spin off a "Lizzie in high school" sitcom onto ABC, but never got to be produced, due to Hilary Duff leaving after the show's completion.
- A pilot for an unaired spinoff series called "What's Stevie Thinking?" was allegedly shot (or at least written), concerning the adventures of Miranda's sister Stevie. Stevie was to be played by a very young Selena Gomez.
- Towards the show's end, there was a contest for three girls to have animated versions of themselves to have a cameo with the animated Lizzie. The show ended before this could have happened.
- Sara Paxton was the front runner to play Lizzie before Hilary Duff was cast. She later appeared in the episode "Election".
- Ethan Craft was originally written to be the school bully. He was changed to a heartthrob and any of his bully qualities were given to Kate.
- After the 9/11 terrorist attack, the clocks in Lizzie's school are set at 9:11 for the episode directly after it.