Randy "Ryo" MacLeanThe first protagonist of the story. A new detective at the 27th precinct that is made Dee's partner at the beginning of the story. He's Japanese-American who was driven to become a police officer by the murder of his parents. He has a very kind and soft spoken outward demeanor but on the inside has many conflicts about his own identity as a man. He often scolds Dee for his advances but deeply cares for his partner and has taken in the orphaned Bikky. He also looks out for Bikky's friend Carol whenever she is in need.
Dee LaytnerThe second protagonist of the story. A detective of the 27th precinct and later the 52nd, he is head over heels in love with his partner Ryo. Often pounces Ryo but has principles and will always look out for Ryo. He is easily amused, well liked but often thought of as obnoxious by the others. He was raised in an orphanage and still sends gifts to the children despite claiming he hates children. He's there for Bikky and Carol whenever they need help even if Bikky isn't particularly fond of him.
BikkyA half caucasian, half African-American orphan that Dee and Ryo meet as a witness during a case. He immediately is hostile towards Dee but takes a liking to Ryo who bonds with him. He's taken in by Ryo and very protective of Ryo. Bikky decides it's his job to protect Ryo from the perverted Dee to Dee's chagrin.
CarolA girl who seemed to live the life of a street urchin until she became a witness to a crime. She pick pocketed Ryo and was caught by Dee. Afterwards she came to rely on Ryo (and to a lesser extent Dee) for help. She is very close to Bikky and she often visits him at Ryo's home.
Voiced by: Wakana Yamazaki (Japanese); Stevie Bloch (English)
Berkley RoseThe Commissioner of the 27th precinct that transferred into that job after taking an interest in Ryo when he met him and Dee during their vacation in England. He is very mature, confident and serious with a piercing gaze. Dee dislikes him and views him as a serious threat over Ryo's affections.
Diana SpaceyA special agent for the FBI that teams up with the detectives of the 27th precinct during a case. She tends to dress provocatively and is a very confident strong woman that can handle herself well. She becomes close friends with Ryo and he confides in her. She openly flirts with Ryo to tease Dee and Berkley. Dee likes to refer to her as a "sea hag".
Jemmy Jay "J.J." AdamsAn old friend of Dee that graduated with him at the police academy. He loves and worships Dee.. to the annoyance of Dee. He's cheerful and eccentric but also the precinct's best shot.
Voiced by: Tetsuya Iwanaga (Japanese); Gary Gillet (English)
Drake ParkerOne of the detectives at the 27th that has known Dee for many years. He is JJ's partner. He is often seen hanging out with Ted and is Dee's drinking buddy outside of work.
Voiced by: Kenichi Ono (Japanese); Bob Bobson (English)
TedIs also a detective at the 27th. He is often doing all the computer related work on cases. He has known Dee for many years and is one of drinking buddies outside of work.
Chief Warren SmithThe beleaguered police chief of the 27th precinct. He is seen as a father figure by many of the officers but constantly yelling at Dee for his shenanigans. Thanks to Dee, many of the officers call him nicknames like 'Old Badger' (Old Tanuki) and 'Walrus'.
Voiced by: Yousuke Akimoto (Japanese); Anthony Mozdy (English)
Rikka "Kai" KaitoThe new chief of the 52nd precinct. He's very serious and appears to have a mysterious past driving his police work.