The title character of Action Henk may not be as fit as he used to be, but he's still capable of running really fast and maneuvering himself around the courses' loop-de-loops and jumps, not to mention being able to keep up with his more slim rivals.
Age of Empires II: The King unit, mostly seen in Regicide games, but also present in some campaign scenarios, is an Adipose Rex that can still run faster than some cavalry units. This is because kings can't fight and running away is their only defense (since regicide games are only won when you kill your opponent's king).
Barry of Alan Wake is heavyset, double-chinned, and can keep pace with the much slimmer Alan and the toned sheriff Sarah Breaker. He occasionally complains and bends over to catch his breath, but Alan himself is a non-athletic protagonist who can only sprint a few meters before he has to do the same.
Oinkie of Anarchy Reigns, who is an obese and round martial artist (not unlike Rufus). And he gets even faster when he transforms!
The Borgia messengers in Assassin's Creed II are visibly overweight, yet are among the most able freerunners in medieval Italy. Rodrgio and Juan Borgia are no slouches in this department themselves.
The Blacksmith and Engineer from Assassin's Creed: Brotherhood, despite being noticeably rotund, can freerun just as well as the other multiplayer characters. Their "rotundness" probably seems to come from the clothing they're wearing.
Downplayed with Lard Lass in Bacon Man: An Adventure; while she does move more slowly than her fellow teammates, the fact that she's able to perform athletic feats like wall jumps at all cements her as this trope.
Attikus from Battleborn has a noticeable gut yet is quite agile like a raging gorilla.
Smough in Dark Souls isn't as fast as Lightning Bruiser Ornstein, but he's pretty quick for someone so huge and bulky. Smough might not actually be that bulky under the armor.
In Dead Rising 2, Randy Tugman is disturbingly obese, but during his boss battle, he can run around the room like a track star. He does have to stop to rest once in a while.
Dino Rex: The Tyrannosaurus can perform some truly wicked fighting moves in spite of its rotund build. Triceratops and the unplayable Monoclonius are also equally fast and versatile, being even capable of rearing up and running on their back legs!
King K. Rool, despite being the most rotund of all Kremlings, is able to outrun Diddy Kong and jump from one side of Gangplank Galleon's deck to the other during his Final Boss battle in Donkey Kong Country.
Donkey Kong Country: Tropical Freeze's Lord Fredrik is so obese that his belly jiggles and bounces with his every movement, and yet he can dodge rapidly, run quickly, and leap great distances with apparently little effort.
E.V.O.: Search for Eden has Debustega, the first boss of stage 2. Despite being a comically rotund Ichthyostega, he's both very agile (able to make tremendous leaps into the air) and very strong.
Cheng Shin Zan of Fatal Fury 2, he has no problems flipping about like any of the thinner fighters in the series. It's the most evident in the Real Bout series where one of his supers has him floating in the air like a blimp.
Saber Julius Caesar of Fate/Grand Order is portrayed as comically obese, which he claims is the result of a half-failed summoning ritual. He's still got a high Agility rank and his updated animations show that he's not only capable of incredibly deft swordplay but also spindashing like Sonic the Hedgehog.
Karnov, especially from the fighting game series, Fighter's History. He plays the final boss for both games released. Even though he's fat, he's is a powerful martial artist and magician. He has the ability to turn his fat into muscle at will. Karnov also had an adventure game named after him for both the arcade and consoles back in the 8-bit days.
The description of the Seeq in Final Fantasy Tactics A2 indicates that, despite their rotundity, they're surprisingly agile. They's generally faster than Bangaa and Nu Mou, which isn't that speedy, but they can jump higher than any other race, allowing them to navigate paths that would otherwise be inaccessible.
Toy Freddy in Five Nights at Freddy's 2 is noticeably bigger in terms of girth than the other animatronics, yet he still moves at a rather high rate of speed.
Elvis from God Hand. Some of the Fat Bastard mooks are also capable of incredibly fast lunges.
...up to and including launching themselves forward headfirst at breakneck speed as living missiles.
Spacegodzilla, much like his film version, is noticeably bulky and quite slow normally. But, if the player uses his levitate/fly ability, he becomes noticeably faster and more agile.
Goldlewis Dickinson, the massive Secretary of Defense from Guilty Gear -STRIVE-, can do some very impressive flips while swinging around a steel coffin as big as him.
Heavy Rain: Do not try to spring an attack on Scott Shelby.
Hitman: Codename 47: In spite of his gargantuan size, Tzun is as fast as any other enemy.
The Great Administrator in Hover: Revolt of Gamers is shown to be quite tubby, and yet he's still able to keep up with the Gamers in the penultimate stage. Hell, the mission name even describes him as "chubby". He's also a Lightning Bruiser, capable of charging towards his foes at breakneck speeds and knocking the ball out of their hands in the last stage. Must be those cybernetic implants he's got on him...
Zeke from inFAMOUS. Despite the fact that Cole jumps off a 20-story apartment building... Zeke is waiting for him at the street somehow, all while touting the biggest beer gut this side of Texas. And that's just one example. There's also the fact that his running speed is actually just slightly less than Cole's. Then there's how he falls into the harbor during the failed escape attempt, yet is waiting for Cole when he returns— even though he admits that he had a crapton of trouble with the swim.
King Of The Monsters 2 might have the biggest example in all of video games, if not fiction: the final boss (King) Famardy, can hop around like a grasshopper despite weighing over half a million tons.note 655,035 tons, if you want to be specific. That's about seven aircraft carriers, or 32 average football stadiums, if you want to know what's jumping around like a frog.
King Dedede from the Kirby series can fly the same way that Kirby does, despite being really fat. And a non-flying bird. For that matter, Kirby's not exactly slim himself!
Peater in The Legend of Zelda: Skyward Sword is rotund and looks incredibly out of shape, but is quick enough with his tiny sword to cut a stalk of bamboo upwards of 30 times before it falls. This odd combination is justified as he was once a top-ranked Sky Knight but has since retired—presumably, Peater was once even better than he is now.
Ganondorf of The Legend of Zelda: The Wind Waker, while still seven and a half foot tall mass of muscles, has gained some extra padding over the years. You'd think he'd be a strong but slow type of boss, right? Nope. In fact, he's the one swordsman faster to the draw than Link, able to effortlessly react to and block all of Link's sword strikes regardless of what direction they're coming from. Unlike most other forms of Ganondorf, the difficulty in this boss fight is due to his incredible speed and hyperalertness.
Sammo/Hong Hakka, an obese child who is one of the three possible successors of the Earthen Heart Shifu in Live A Live. Justified in that he's used to running away from restaurants without paying. He's based loosely off of Sammo Hung.
Joe Barbaro from Mafia II is extremely capable in combat.
Mappy: The eponymous character is depicted as being overweight on cabinet artwork. In game, he's pretty light on his feet.
The volus in the multiplayer part of Mass Effect 3. They are actually a odd subversion of this trope. The basic character is capable of both rolling in all 4 directions (forward, back, both sides) and taking cover behind walls, corners and low objects. Tougher races such as Krogan and Batarians can use cover, but can't roll. A few races can use cover, but can only hop (roll) to the sides (Quarians, Salarians, Geth). The Volus are a short race of ammonia breathers who always wear environmental suits that make them look like short (half the height off anything else), round teddy bears. In an odd subversion off this trope, they can run as fast as any other character (which looks odd, given their short legs) and can roll in all 4 directions... but cannot use cover. I.E. they have the same agility as anyone else, but cannot do one thing that every other character can.
The Thanatos in MechWarrior Living Legends is an extremely wide battlemech — often likened to a barn with legs — which is the most agile and quickest Heavy mech around, comparable to many medium mechs. It typically mounts either MASC or jump jets for maximum agility, and is capable of rotating its torso in a 360-degree arc to always keep an enemy within its sights. It's not the most powerful heavy around, but its combination of speed, armor, and overall firepower make it a potent Lightning Bruiser. It has a Weaksauce Weakness in its terrible hill-handling ability thanks to its Chicken Walker design.
Bounce Man from Mega Man 11 is the biggest and roundest Robot Master in the series, but due to being essentially a giant rubber bouncy ball with limbs his fighting style involves a lot of bouncing around the screen. He's even equipped with a Speed Gear instead of a Power Gear.
In Metal Gear Solid 2: Sons of Liberty, Fatman can zoom around the map and pirouette on his in-line skates, in spite of his size and heavy blast suit, and while drinking glasses of red wine through a straw.
Similarly, Metal Gear Rising: Revengeance features the leader of the Desperado PMC, Sundowner. He's easily the tallest, widest member of the group, and his armor even incorporates a visible beer gut. Despite this, he leaps from the ground to the roof of a building in his introduction cutscene, and can move quickly enough to almost count as a Flash Step during his boss fight.
Bo Rai Cho in the Mortal Kombat series. (In fact, in at least one game, he uses Sumo as one of his fighting styles.)
Hard as it is to tell from the art style of Night in the Woods, Mae is indeed supposed to be quite overweight, as stated in her dialogue and sprite's general roundness, and she just spent the last year mostly eating pizza and not moving. This doesn't stop her at all from running around, making high jumps, and balancing on phone lines. Then again, she is a cat.
Dynamo and Alternator from Ninja Gaiden are very rotund but can swing and charge very fast.
Ninja: Shadow of Darkness has a Sumo mercenary as a Badass Normal boss halfway into the game, who is surprisingly fast and agile despite his size, capable of scaling all corners of the arena within seconds and pursuing the player's ninja hero.
Oriental Legend, an arcade game based on Journey to the West, has Zhu Bajie as a playable character, and he's amazingly fast and lethal for his size, despite his bulging oversized gut constantly getting in the way.
Paleo Pines: Despite being wide, quadrupedal herbivores, the Dinopedia points out that Desmatosuchus are among the fastest sprinters in the game.
Pizza Tower: Peppino Spaghetti, much like Wario which he is heavily inspired from, is an overweight pizza chef capable of feats such as running at high speed, dashing in mid-air, scrambling up walls and pummeling foes with Rapid-Fire Fisticuffs.
Protect Me Knight: The Amazon, who is portrayed with a chubby and voluptuous figure and the butt of any jokes involving her cravings for sweets, is capable of performing feats such as quickly stabbing foes with her spear, dashing, lifting barricades/turrets or the Princess, and keeping up with some of the other characters with enough skill level ups and the skills being used. In her own mini-game, Amazon's Running Diet, she is capable of doing high jumps, jump kicks that extends her air time, back flips, and sliding all while running at the same time.
In Pokémon Sun and Moon, Snorlax gains the Z-Move "Pulverizing Pancake", where it wakes up, does a flip to its feet and proceeds to run at its enemy at top speed before jumping up into the air and sitting on them.
Miltank is big and fat like you would expect a cow to be... but it has a base Speed stat of 100.
Purugly are pretty fat and bulky looking Pokémon with Fragile Speedster-like stat distributions.
Stoutland is a fat doglike Pokémon that, nonetheless, moves pretty fast as a Ride Pokémon in the Gen VII games. It can also have the ability Sand Rush, which boosts its speed when a sandstorm is happening.
At over 8ft. tall and weighing 442 lbs., Scolipede is the largest and heaviest Bug-type. However, it is also a Fragile Speedster that edges into Lightning Bruiser territory. Its Hidden Ability is even Speed Boost, an ability that increases their speed stat every turn.
Despite Dragonite's bulk, multiple Pokédex entries state it can circle the globe in 16 hours, which would make it faster than sound assuming the Pokémon world is the same size as Earth. Speed is its lowest stat, but it's still respectable at 80.
Typhlosion does not look like it should have a base 100 Speed (that's faster than some nimble Pokémon like Lucario) with those little stubs for legs, nor should Gengar, who's even faster.
According to the Pokédex entries, Hydreigon spends all its time eating everything in sight with its three snake heads, all of which goes to one bloated body somehow able to fly with those six skinny little wings... and what do you mean, it has a base 98 speed?! It's also able to use both Acrobatics and U-Turn, which are otherwise reserved for the more agile-looking fliers.
With its Mega Evolution, Metagross takes the crown for this trope in the Pokémon series thus far. It weighs almost one metric ton, making it the second heaviest Pokémon right after Groudon while being as fast as Gengar.
Tierno, one of the rivals in Pokémon X and Y is a dancer who is very round.
A human character that fits is Evice, the true Final Boss of Pokémon Colosseum. An overweight old man, he can nonetheless do backflips and somersaults during the battle.
Drei Belanos from Project × Zone. He's pretty limb for a big guy. As in doing a Wall Jump in thin air.
Helga, the pleasantly plump robot from the Ratchet & Clank series, is introduced as Captain Qwark's personal fitness trainer. Although Helga is constantly portrayed as being extremely physically fit due to her high standards, the only proof of this is the Up Your Arsenal skill point, "Beat Helga's Best Time", in which it is suggested that she conquered the VR Hacker & Hypershot training course in 0:50 seconds.
Raging Justice have the overweight Giant Mook enemies whose bellies literally bulge out of their sides (two debuting in the second stage as a Dual Boss before getting degraded into common enemies later) who can run and jump surprisingly fast despite their girth. There's also Mayor Wilson, the Big Bad who's a mountain of fat towering over you, but can run back and forth at rapid pace around the boss arena while trying to slice you up via chainsaw.
In Rayman Origins and Legends, Globox can run, jump and fight in the same way as the other characters despite being a large and obese frog-like creature.
The Wall Jump is something usually given to nimble characters. Folks with, say, ninja training. Thus, the ninjas in the Samurai Shodown series tend to pull this off. Including Earthquake the Texan ninja, who lives up to his name.
The Simpsons: Homer Simpson in almost every game where he's a selectable character.
Murray from the Sly Cooper series qualifies when you play as him from the second game on. He can jump through the air and sidle along walls just as sneakily as Sly can.
Dr. Eggman spends most of his time in machines, but when he gets out, he tends to display impressive feats of strength and agility. These range from keeping pace with Sonic himself and competing as an Olympic athlete, to being able to punch a moving train and knock it off its tracks in Sonic Riders. Notably, in Sonic Lost World, he was able to shatter a large wall of ice with his bare hands.
Big the Cat also qualifies. He's enormously fat but also superhumanly strong, and in Sonic Heroes he has no problems navigating the loop-de-loops with his teammates.
Octosamurai in Splatoon 2 is an incredibly large, incredibly rotund Octarian, but one who lives up to his name, performing quick slashes with his weapon, leaping across the stage, and in general moving a lot faster than any boss in the first game. He also spends a lot of time on what appears to be a unicycle and controls it so well that he's a better fighter thanks to it.
Luther from the SSX games. Obese? Definitely. Capable of decatuple backflips under the right circumstances? Oh yeah.
Darth Baras from Star Wars: The Old Republic qualifies. He's a fat Sith sorcerer with obvious man boobs and oversized robe. Yet his class in the actual boss fight you fight him in is Sith Warrior, complete with acrobatic jumps and leaps. You'd expect him to be a Sith Sorcerer who relies primarily in lightning attacks since in the cutscenes he spams lightning like a typical spell caster, but nope. Get ready for Darth Fatass to knock you halfway across the map with an elbow only for him to Force Jump to your location and whale on you with lightsaber moves.
Also any player character in The Old Republic can be this, since the body model Darth Baras uses is available at character creation. This may actually be a subversion; the model looks fat in a robe or loose outfit, but in armor or shirtless it's clear they are barrel-chested and ripped. Those aren't man-boobs, those are pecs bigger than the average-size model's entire chest.
E. Honda and Rufus (pictured on the main trope page) in the Street Fighter series. Mostly Rufus though. While Honda is no slouch, capable of leaping very high in the air (even doing somersaults in some versions) and launching himself at opponents like a missile, he's still got elements of Mighty Glacier. Oddly, the most recent games depict him with a sumo's build that seems to be completely made of muscle without any visible body fat. Conversely, look at the gelatinous, almost-spherical Rufus: He's not only strong but among the most agile characters in the game. This combination makes many complain that he's broken (after all, the whole point of the Mighty Glacier is that he's powerful, but is slow, so as to give lighter and faster characters a chance).
Street Fighter X Tekken has Joke Character Bad Box Art Mega Man, who is a middle-aged, overweight man in an ill-fitting jumpsuit, yet he is surprisingly athletic. He is based on the infamous North American NES cover art for the original Mega Man game where instead of appearing as an adorable blue robot boy, he had appeared as a hideous, out-of-shape man in spandex with weird legs.
The mobile phone game Subway Surfers features you being chased by a large police officer or security guard. He's always behind you even as you're running across train tracks and jumping from train to train.
Wario in the Wario Land games and Wario World is very agile and acrobatic for somebody his size. It has gotten to a point where he is able to catapult himself up high by swinging on bars.note This however gets heavily subverted if he becomes Fat Wario, who's so fat that he can't even jump very high, let alone move fast. Then again, that's probably not the point since he can use his increased bulk to destroy otherwise-unbreakable blocks. In the Mario Strikers series, he can backflip and kick a ball in mid-air as well as celebrate by doing the splits. In Super Smash Bros. Brawl, he has some very fast attacks and extreme aerial maneuverability for a heavyweight. His Final Smash form, Wario-Man, is even faster and stronger and can jump absurdly high to boot. Oh, and the Shake King from Wario Land: Shake It!. He can do everything Wario can (jump across the room, charge, etc.) as well as fly while shooting laser beams and electricity at things. It's downplayed in Super Mario 64 DS as Wario is the least agile of the four playable characters, but he's still able to do jumps that average humans would struggle to pull off.
Downplayed with Mario, as he is more of a Pint Sized Power House. He's not noticeably fat like Wario, but he does have a belly, and yet is still capable of pulling off acrobatic feats that would put real-life gymnasts to shame. He wasn't originally called "Jumpman" for nothing, and his speed, agility, and hang-time have only increased since then. Shigeru Miyamoto explained that his plump shape was to allow for easier collision detection in '80s hardware. Design-wise, Mario probably isn't fat in a technical sense but just appears round, especially in comparison to the other and much more extreme examples in this trope.note And by that logic, the same could be said of his brother, Luigi, who has a pear-shaped body. It's worth noting that since Luigi started out as a Palette Swap of Mario in the '80s, he was chubby like Mario until technology advanced and he was slimmed down considerately to contrast with Mario. Mario's current design looks to be much thinner with longer limbs and is possibly an average size who is just slightly pudgy at best, compared to previous decades when he was shorter and quite tubby. Played straight with Hotel Mario (due to how extra chubby he looked in that game, he is called "Fat Mario" for a reason); in the cartoons, he was depicted with a huge potbelly.
Bowser dips in and out of this trope, depending on the game. Bowser is typically the Mighty Glacier, living up to the "slow but powerful" character type, but in some games, Bowser can run and jump as well as Mario can. Even when he's portrayed as slow and a bad jumper, Bowser's still usually shown as quite agile, pulling off the flips and spins Mario is so known for with just as much ease. If Dance Dance Revolution Mario Mix is anything to go by, Bowser is also an incredible dancer and can pull off breakdancing with ease, despite his bulk.
Dodo in Super Mario RPG is so rotund that he needs help fitting through a castle door, yet he's one of the fastest enemies in the game.
The Elephant power-up in Super Mario Bros. Wonder turns any member of Mario's gang capable of using power-ups (all of them except Yoshi and Nabbit) into a huge elephant. Despite their new size, they retain all of their movement options, including wall jumps, spin jumps, and whatever other power they may have from their equipped Badge.
The Veteran is a pro wrestler inspired by Vader. He's a hybrid of the Enforcer class type and the Commando class type, making him a heavy and powerful pro who can move like greased lightning.
Where the Veteran is hefty, the Wascot is just flabby, but his lunge is very acrobatic and he's an accomplished breakdancer, much like the focus of his obsession, SMNC mascot Bullseye.
Team Fortress 2: The Heavy, usually the slowest class, gains a significant speed boost when equipped with the Gloves of Running Urgently or for a brief period after eating a Buffalo Steak Sandvich.
Normally, players that are able to get their heavy the high ground can drop down on enemies in manner similar to this trope. His regular running speed isn't that slow (about 4/5 the average); he's mostly a Mighty Glacier because he has to slow down to use his minigun. Even then, this doesn't keep him from turning around as fast as the player can move the mouse, as many a Spy has discovered.
Pyros are fairly portly themselves or at least wear baggy clothing, and yet are notorious for how fast they can move. They move at the average speed normally, and faster than any non-Scout class if they're holding the Powerjack.
Bob in Tekken 6. Justified, as much of his considerable bulk is actually muscle. He's a Sammo Hung tribute. According to his backstory, Bob was once a very fit fighter who wanted to take his skills to the next level, and developed his body accordingly; implicitly, he was less agile before he gained all that weight. You can use the average-build version of Bob in Tekken Tag Tournament 2 (he's still pretty nimble but some of his moves account for weight he no longer has, which trips him up and changes some of the properties of his moves).
Munch in Tribal Hunter can run and jump with little issue if he grows to be quite fat. This goes out the window if he gets too large since his huge size prevents him from doing wall jumps and his punches launch more slowly. He can still perform his double jump at huge sizes, but if he reaches the immobile size, he's a sitting duck. Many bosses in the game are also quite portly but can still move and jump around fairly fast.
Pandaren are a whole race fitting this trope. They are all obese, and there's even dialogue in-game where they discuss openly wanting to gain more weight because their strength, one claims, is tied to the size of their belly. Even still, they are one of the most agile creatures in Azeroth, known across the world for their exceptional agility and fast-paced fighting style.
They can also trigger a party-wide movement speed boost with Stampeding Roar. Bears can run at 30 mph.
There's also the "RAWRBOMB" technique, in which a Bear Druid charges from freefall.
The Grendel Warframe is stocky, rotund of build, and quite the glutton. Despite this, he's still a warframe, and is still more than capable of bullet jumping, wall running, and other such acrobatic feats - all the better to catch up to a prospective meal.
Wonder-Green of The Wonderful 101 is an overweight kid who's pretty nimble on his feet despite his size. On the other hand, he's also shown to be quite clumsy at anything that isn't a gun.
There are also minor Wonderful Ones such as Wonder-Toilet and Wonder-Beer, who despite being fat can move just as fast as their thinner teammates and hold their own against the GEATHJERK forces.
Ben of Zenless Zone Zero is both extremely large and extremely fat as a bear demi-human. He runs just as fast as the rest of the cast, if by covering more ground with each step as a normal-sized humanoid, and can swing his weapon, a giant pile driver, with incredibly lethal speed and agility.
of Assassin's Creed runs very fast for a guy that big.