Draco in Leather Pants: Ganondorf in a three-piece business suit has quite a few admirers in the readership. It does help that with this version, he's far less antagonistic and has gotten sick of the standard routine of "Go out, kidnap a princess, and get sealed into the aether for centuries." It also doesn't hurt that he's one of the few who work at the office who's actually stable enough to maintain a regular job; he's almost never seen getting up to the crazy shenanigans that the rest of the people there do.
Ensemble Dark Horse: The velociraptors. Often people comment on how cool and/or adorable they are every time they show.
Foe Yay: The Punisher and the Russian. They're shown in bed together. And the Russian is in his reanimated body (which included Gag Boobs as a side effect).
He Panned It, Now He Sucks!: Coelasquid got this reaction from Skyward Sword fans when the below mentioned parody comic (which is mostly making fun of Fi) had a description from her saying that she hated the game itself as well. Probably not helping her is that a select few fans felt that her responses to the people who disagreed with her opinion came off as a bit vitriolic.
Tywin Lannister being referenced in a comic back when it was a relatively obscure reference. *Particularly* funny in that the comic's title bemoans the fact no one will get it, while the then-upcoming HBO series mentioned in the description would become a massive cultural phenomena.
The strip where Kenshiro becomes a fast food worker becomes hilarious with the minigames in Fist of the North Star: Lost Paradise. There's a minigame where Kenshiro becomes a food vendor who serves food via Hokuto Hyakuretsu Ken. Sadly, Kenshiro doesn't punch the shit out of the patrons.
Before that, there was a parody spinoff called DD Fist of the North Star which is about Kenshiro and the cast in a world where their badass powers are severely out of place in the modern non-apocalyptic world (Kenshiro takes a job at a convenience store), which is a similar premise as this comic.
Kratos' 2018 game and its memetic names "Dad of War/Dad of Boy" given that they make Kratos in a much more reasonable figure not defined by solely his rage at past slights. Naturally there have been strips of him being a dad and how proud Commander Badass is of how far he's come, but it's still funny.