A very mild example. Coelasquid was prompt and reliable about updating the comic early on Mondays for years - usually at around midnight her time, if not a couple hours earlier - until the middle of 2016, where she revealed that her new real life job involves working on the Ben 10 reboot. Thus, some comics have had their line art delayed to Tuesdays, but the fanbase is completely supportive and knows not to complain.
A much more significant one began in July 2018. As of November 2018 the strip has still not been updated, but nor has Coelaquid announced the strip's cancellation.
Throw It In!: The chaos left behind when the Commander and Jonesy went to the future was originally just going to be generic chaos, but then Twitch Plays Pokémon came out and Coelasquid was inspired to make a homage to it (specifically the original one, Twitch Plays Pokémon Red).