Buford is a smart but sleepy bloodhound, living deep in the murky swamp country of Fenokee, who teams up with two teenage humans, Cindy Mae and her older brother, Woody. The trio solves mysteries that baffle Sheriff Muletrain Pettigree and his overeager yet dimwitted deputy, Goofer McGee. Buford's abilities are expanded with ears that revolve like radar dishes, and his nose responds to clues like a Geiger counter. he also howls his heart out when the moon comes out and has a running feud with a brown raccoon.
Nugget Nose is a short and feisty ghost prospector who finds adventure riding his invisible horse. He is also a guardian to Wendy and Rita, two cowgirls working at the Fuddy Dude Ranch, whose owner is grouchy old Fenwick Fuddy. Nugget is always battling Fuddy and takes delight in harassing him in odd and humorous ways. Whenever the girls are in trouble, Wendy summons Nugget Nose by rubbing her special nugget necklace.
This cartoon provides examples of:
- Frank Welker provided voices for both Buford and Nugget Nose.
- Our Ghosts Are Different: Ghost Prospecter
- "Scooby-Doo" Hoax: Both examples of the same formula
- Two Girls and a Guy: Wendy, Rita and Nugget Nose
- What Happened to the Mouse?: In the Space Race segment (later spinoff) while Wendy, Rita and Nugget Nose are all together, Buford's Meddling Kids Cindy Mae and Woody aren't included and instead Buford is paired with Jabberjaw.