- Fake American: Chris Hemsworth, who is from Australia, adopted a U.S. southern accent to portray his character.
- The Other Darrin: Anthony Michael Hall, Ethan Embry, and Johnny Galecki were offered to reprise their role as Rusty Griswold for this film before Ed Helms was eventually cast. Dana Barron was also asked to return as Audrey... before Leslie Mann took the role.
- Role Reprise: Chevy Chase and Beverly D'Angelo return as Clark and Ellen Griswold.
- Sequel Gap: The film came out 18 years after the previous film, Vegas Vacation. 32 years after the first Vacation.
- What Could Have Been:
- A previous synopsis of the movie had Walley World closing permanently.
- Will Ferrell, Michael Rosenbaum, Adam Sandler and Jason Sudeikis were considered for Rusty.
- Randy Quaid couldn't reprise his role as Cousin Eddie, due to his arrest involving a house payment dispute. Quaid currently lives in Canada. His character does get a mention.
Trivia / Vacation