- Acting for Two: Brian George voices the pirate captain and Haggis, the bos'n and Queeks are both voiced by Corey Burton, and Martin Rayner voices both Alfred, Spiny and the first mate.
- Actor Allusion: "Elephant Walk" wasn't the first time a character played by Nancy Cartwright demanded an elephant.
- Cowboy BeBop at His Computer: Some articles state that Mike is from the Bronx instead of Manhattan.
- He Also Did:
- Co-creator Charles Swenson also directed/animated Down and Dirty Duck and the cartoon sequence from 200 Motels, as well as co-directing The Mouse and His Child and Twice Upon a Time.
- Some of the writers also had experience on live-action projects. For example, Lance Khazel ("Whole Lotta Shakin'", "The Great Snipe Hunt", "Jujubombs" and "Sneeze, Please") also wrote Son of the Mask and Susan Sherman wrote for That's So Raven and Cory in the House.
- The Other Darrin: Kath Soucie (who normally voices Margery and Pig) filled in as Lu for a few lines in "Scuba Doobie Doo".
- Screwed by the Network: Cartoon Network canceled the series after two seasons, despite it still having a rather significant fanbase (the series was never given its an adaptation in the Cartoon Cartoons comic books, even though many fans kept writing in and requesting it). Similar to Sheep in the Big City after it, the second season suffered from a VERY stretched and sporadic release schedule. It didn't help that it debuted alongside Courage the Cowardly Dog, which immediately became a network favorite and ended up overshadowing Mike, Lu and Og.
- Talking to Himself:
- Dee Bradley Baker voices Og and Goat, who frequently speak to each other.
- Plus in "Night of the Living Ancestors", the characters speaking with the ghosts are basically talking to themselves.
- S. Scott Bullock voices Wendel and Baggis.
Trivia / Mike, Lu & Og