The blurry photos of Superman from the first episode make a lot more sense given that Jimmy has known Clark's secret since college, so it's likely he took terrible photos on purpose to protect his friend's identity as best as possible.
In Episode 2, Jimmy calling Clark during Livewire's bomb threat seems to have been, at best, a convenient butt-dial on a first viewing. Knowing that Jimmy is well aware of who Clark is and what he can do, it's more likely he called Clark deliberately in order to get Superman to the scene as quickly as possible while playing it off as an accident to hide his knowledge. This becomes even more likely when you consider where in the conversation they are when Clark answers the call, and that Pa Kent had to carry the phone to him from another room. More than likely, Jimmy dialed Clark as soon as he spotted the bombs.
In a sense, combining Ivo's AMAZO android with Parasite makes sense. Both AMAZO and Parasite are known to steal power, with Parasite as a Power Parasite and AMAZO known for Power Copying. So having them as a Composite Character is fitting in a way.
The new design for Mr Mxyzptlk here could potentially have an in-universe explanation. Stories such as Superman Reborn and Superman: American Alien suggest all versions of Mxy across the multiverse are the same entity, taking on different forms suited to them for each world. Given the Animesque nature of this show, Mxy taking on a cuter, more impish form and looking like something out of Dragon Ball fits this concept, with this being how the entity blends into this universe.
This is supported by how his Amplifier Artifact tiara takes on the form of a bowler hat, like the one his regular counterparts wear, when not on his head.
Vicki Vale's Beware the Superman mindset makes a lot of sense when you consider she comes from Gotham City, whose own defender is under constant scrutiny despite his efforts to protect the people.
The hints that The General may actually be Lois Lane's estranged father adds another layer of Irony towards his interactions with Superman, given his visibly seething anger at the Kryponian's apparent audacity at "pretending" to be a good-natured hero when he believes he's really a secret scout for an impending alien invasion — like his daughter, the General hates liars. Furthermore, unlike his daughter Clark has never once lied to him in all the times they've spoken, but The general's cynical outlook means he just can't handle the truth.
Double that irony by adding in the understanding that Clark is being grilled by the father of his girlfriend. Most people already dread such a scenario, but this one has the awkwardness ramped up to eleven (if not higher).
The title "My Adventures with Superman" starts to make more sense as the series goes along. It gradually becomes clear that Superman's greatest enemy isn't some supervillian who can physically match him or even an individual he's ideologically opposed to, but rather the fear others have towards the unknown that Superman represents. This is not a problem that any of Superman's powers can fix — in fact, using these powers at all just increases the distrust towards him that gradually builds up as it becomes more obvious how strong and varied Superman's abilities are, all concentrated in one man with no apparent countermeasures — and his sincere attempts to explain himself and tell the truth are dismissed out of hand, as he's too "other" for the masses to take what he says at face value, not to mention the rampant cynicism amongst the populace towards meeting somebody who appears to be an Ideal Hero. Such a character is simply too pure and "good to be true" to actually exist, and Superman seeming to be without flaws just invites skepticism and distrust from others who instead redouble their efforts to find some kind of flaw or moral failing in him, ironically as that would in fact make Superman more "human" and relatable. Instead, the ones who can actually counter this are Superman's non-powered allies Lois and Jimmy. They can present Superman's actions in a positive light towards the populace through the Daily Planet and their reporting, filtering his good intentions through their words and writing in a manner that people are more willing to accept, in turn gradually decreasing the animosity that people are harbouring towards the powerful alien living among them. Their interactions with Clark throughout the show even help humanise him more to the audience, showing how Clark is genuinely flawed and has the capacity to make mistakes even with his well-meaning usage of his powers and the responsibility that comes with them. From lying to Lois and causing a strain in their relationship to accidentally standing Jimmy up and constantly lying to him too about all the damage he causes from his Power Incontinence, the show demonstrates both how Clark can have good reasons for doing these things, and still be wrong, as well as grow and improve from them as he learns from his failures. The title is written as it is because it's Lois and Jimmy both humanising Superman whilst also demonstrating that he is still the super-human protector of Metropolis.
It also takes on a deeper meaning when you realize this version of Clark doesn't yet know exactly who or what Superman is, he hasn't been practicing very long, and he can't even access the Fortress of Solitude's data because it's in unsubtitled Kryptonian (which this version can't instinctively understand). In many ways, Clark is also along for the ride, making it also his adventures with Superman as well. It's very subtle, but clever.
Ivo's character throughout the series is a showcase in how self-destructive The Power of Hate can be, as his Parasite armour at times seems to react to his hatred of Superman and feeds into it, even as Ivo himself loses more and more thanks to over-indulging in that same hatred. Initially, Ivo's Parasite 1.0 suit is an exemplification of this, as it relies on Superman retaliating against it to keep fighting, and he simply beats it by refusing to attack at all despite Ivo's provocations. It's hinted that Ivo targeted Superman as a demonstration in part because of envy at his popularity and fame, and this evolved into outright hatred over Superman refusing to justify Ivo's animosity towards him and denying him the satisfaction of a proper conflict. Without power from Superman, Ivo's refusal to stop his spiteful attacks on Clark eventually exhaust the remaining power in the suit and make it backfire on Ivo himself, disfiguring him through his own hate almost literally consuming him. Much like an extremist will warp a series of events to support their hate-filled causes in reality, Ivo focuses on the disfigurement that resulted from his fight with Superman, whilst ignoring his own culpability, becoming obsessed with Revenge on Superman and developing his next suit to be more dangerous to him now he has a cause to channel his energies into. Ivo's Parasite 2.0 suit rectifies the weakness by allowing him to drain on touch, but he only developed this suit with support from Task Force X, much like an extremist can become dangerous if others believe their hateful rhetoric and support them, since both sides believe Superman is a common enemy that must be taken down. In their second fight, the stress from being ambushed and his days-long sleep deprivation actually makes Clark fight back more against his aggressors, defeating the rest of task Force X with a Heroic Second Wind, but because he actually retaliates, Ivo is able to absorb that power and come close to killing Superman before the General interferes. In their third bout, stripped of his restraints, Ivo indulges in his hatred against Superman, lashing out against everyone without care, exactly like a hate-filled extremist wouldn't care about collateral damage in enacting their cause, even their erstwhile allies. Draining power from the city to fuel his rampage against Superman mutates Ivo's armour further and further from its semi-humanoid proportions, eventually turning him into a biomechanics Kaiju as he becomes utterly consumed by his hatred against Superman in mind and body. Fittingly, it is again being denied the support he craves/needs that Ivo is defeated, as the masses uniformly deny his "cause" by turning the city's power off to support Superman, leaving Ivo vulnerable without anything to feed off of metaphorically or literally. Superman again spends their third bout refusing to fight back, albeit because he's still in a Heroic BSoD from learning about Zero Day, but because he still doesn't retaliate and protected everybody so selflessly, the city can see who the real monster is between them.
The General is convinced that Superman is an alien threat that will destroy everybody on Earth, and is the main idealogical opponent towards Superman's efforts as a hero, constantly undermining his claims that he's helping people with his powers just because he can. Despite his accusations, aggravations and painful rebuttals to his protestations, Superman never retaliates towards his aggressor, trying to seek a peaceful resolution to the animosity he has towards him, whilst keeping his friends safe from the crossfire. It's ultimately witnessing Clark's genuine remorse for the damage done on Zero Day, a level of empathy and humanity that Nemesis Omega isn't capable of, the makes the General realise he was wrong to assume they were the same being, being furthermore accepting of the idea because of how Clark never went too far against Task Force X's assets despite all the reasons they gave him to. Despite his own hatred of the alien menace that nearly conquered the planet and killed him, the general has enough empathy in him to recognise that his hatred is blinding him to the real enemy, ultimately being swayed to Clark's side because he showed he was more human than the threat the General imagined.
That among all the criminals they have captured, Task Force X chooses to use Mist as The Bait to lead Superman into a trap is the most logical idea. Remembering the glee the other villains show when they make the hero suffer, none of them could have been patient or convincing enough to trick Superman, knowing they were going to take him to an area where they could attack him all they wanted. Mist on the other hand, does not have any enthusiasm or sadism, so as seen in the end, he was the best option for Superman to believe him.
If one looks closely, Mist is one of the few antagonists in the series that did not face Superman directly in battle, since he has not been his direct enemy, the hero would not see him as a threat when realizing that he is alone and it would be easier to take advantage of the Superman's kind nature.
Connecting with The General's Even Evil Has Standards, Mist was also the least dangerous criminal to release. Mist would not be tempted to attack civilians to create the lie that would lead Superman to be ambushed by Task Force X and in the hypothetical situation that the villain managed to remove his shock collar, Mist would not be a great danger with his invisibility and it would be easy capture him without causing collateral damage.
Task Force X still has the rest of Intergang locked up. They know Mist won't abandon them and that he can't go rogue for fear that they actually will move his crew to a facility he can't find.
The League of Loises chasing after Mxyzptlk seem to automatically assume Clark has gone rogue and teamed up with the imp, rather than try to find out first if Mxy tricked Clark into doing so (which was the case). When you consider Lewis has a cybernetic arm, and that the League carries kryptonite weaponry at the ready, there's serious evidence these are the Loises from universes where Supermen went bad.
In Episode 10, after Superman inserts the kryptonite into the ship's crystalline computer core, the entire crystal turns into the bright green of kryptonite. The ship promptly explodes in low Earth orbit. Superman might've inadvertently seeded kryptonite crystals into much of North America.
