These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
And your mileage won't even vary here. It's over 4000 friggin entries as of November 2011. However, it's worth reading every page, even if it took this troper three whole weeks to do it.
Archive Panic: This webcomic started in January 2000. According to the archive, it's been updated almost every day...for 12 years. At about 350 (or so) comics a year. Not as bad as some of the other examples on the Archive Panic page, but getting there.
Also the whole Sisterhood plot in general for stealing the spotlight from most of the cast in general. To some it has been labeled as when the comic Jumped the Shark.
Subverted in that, while generally portrayed as appealing (especially when compared to the alternative), the devil's pleasures are ultimately unsatisfying. Even for himself.
Played straight by the succubi, until Fuschia's Character Development made her not so evil anymore.
Fridge Logic: Lil' Evil frequently mocks the damned, but what does he think is going to happen when he makes it to the other side himself?
Well, there seems to be a big difference between being the damned souls and being the demons who torment them; he probably assumes he will end up in the second group.
Ho Yay: A few strips on bromance get pretty close to this, but the most obvious is Lil'Evil and his feelings for Satan...until we learn that Lil'E is actually the devil's son.
Baby Blue has been subjected to Good Feels Good a few times, but unlike Fuschia something tends to go wrong before it has any chance to stick, sending her back to square one.
The Devil and Lil' E now that we get to see some of their backstory.
Jerk Sue: Trike Girl is every bit as much a fanatical misandroist bitch as Seymour is a fanatical misogynist pig. She never gets called out or suffers bad karma for her behaviour.
One could argue that Trike doesn't really do anything particularly jerky. She tries to enforce her Ideals in a similar-ish fashion to Seymour, but is much more passive about it when compared to him really. She spends more time encouraging females than she does attacking males, which is the kind of behaviour that would reallypush her to Jerk Sue levels.
Moe: Criminy, Fuschia, Pooch, Percy, Squig, Buddha and Tangerine.
Moral Event Horizon: Seymour hit this for many fans in the "Bad Behavior" series, when he went on a particularly hateful fundie racist speech to a reformed Fuschia. She understandably went berserk and tried to kill him, then Criminy called him out on it after yet another speech.
Though a quick look at the Characters page, the Awesome page, the Heartwarming page, and even the main page will tell you that it seems to be the most referenced, popular story arc in the comic.
The Scrappy: Seymour has started to gain a considerable hatedom after the September 14th, 2010 block of strips, especially after a recent Despair Event Horizon.
Straw Feminist: A new as yet unnamed character who has been given several consecutive focus strips is nothing but this. An award should be given for how offensive she manages to be in less than a week of comics.
Well, she is obviously, like Seymour, a character meant to represent and criticize a form of extremism, only feminism extremism, rather than religious extremism, and an arguably funny and laughable one at that, since she looks like a feminine, polar opposite of Slick in his worse moments.
The problem being that nobody treats her like they would Slick.
The Woobie: Most of the non-deity characters have gotten moments of this, but Fuchsia, Squigley, and Slick are the most frequent, especially Squig over the course of 2010.
The Zombie. Have you EVER wanted to comfort a mass of undead, maggot-ridden flesh this much since Corpse Bride?